34444-01-4

• 常用中文名：头孢孟多
• 常用英文名：Cefamandole
• CAS号：34444-01-4
• 分子式：C₁₈H₁₈N₆O₅S₂
• 分子量：462.50300
• 相关类别： 原料药 抗生素类药物 头孢菌素类药
• 发布时间：2018-07-09 14:35:18
• 更新时间：2024-01-02 10:16:39
• 抗生素类药

名称

• 中文名: 头孢孟多
• 英文名: cefamandole
• 中文别名: 羟苄四唑头孢菌素; 7-[(2-羟基-2-苯基乙酰)氨基]-3-[(1-甲基四唑-5-基)硫甲基]-8-氧代-5-硫杂-1-氮杂双环[4.2.0]辛-2-烯-2-甲酸
• 英文别名: cefamandol; MFCD00056872; 7-[(2-Hydroxy-2-phenylacetyl)amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; Florfenicol-d3 AMine; CEFAMANDOLE; cephadole; cephamandole; cefadole; EINECS 252-030-0

物化性质

• 密度: 1.75 g/cm3
• 分子式: C₁₈H₁₈N₆O₅S₂
• 分子量: 462.50300
• 精确质量: 462.07800
• PSA: 201.14000
• LogP: 0.10320
• 外观性状: 白色至灰白色粉末
• 储存条件: 库房低温通风干燥

生物活性

• 描述: Cefamandole是第二代广谱头孢菌素类抗生素, 抗生素在体内分解, 释放游离NMTT, 可导致低凝血酶原血症。
• 相关类别:
  信号通路 >> 抗感染 >> 细菌
  研究领域 >> 感染

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : XI0383700 CHEMICAL NAME : 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-((hydroxyphenylacetyl)amino)-3- (((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-, (6R-(6-alpha,7-beta(R*)))- CAS REGISTRY NUMBER : 34444-01-4 LAST UPDATED : 199612 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C18-H18-N6-O5-S2 MOLECULAR WEIGHT : 462.54 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 15 gm/kg/5D-I TOXIC EFFECTS : Kidney, Ureter, Bladder - other changes in urine composition Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 30,660,1980 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 30 gm/kg SEX/DURATION : male 30 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - testes, epididymis, sperm duct REFERENCE : FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 8,280,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3194 No. of Facilities: 299 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 16094 (estimated) No. of Female Employees: 13604 (estimated)