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84601-19-4生产厂家

84601-19-4价格

84601-19-4

84601-19-4结构式
84601-19-4结构式
  • 常用中文名:磷酰胆碱
  • 常用英文名:Oleyloxyethyl Phosphorylcholine
  • CAS号:84601-19-4
  • 分子式:C25H52NO5P
  • 分子量:477.66
  • 相关类别: 原料药 神经系统用药 拟胆碱药
  • 发布时间:2018-07-17 23:22:47
  • 更新时间:2024-01-02 18:33:53
  • (Z) -酰氧乙基磷酰胆碱((Z)-OPC)是酰氧乙基磷酸胆碱(OPC)的异构体。酰氧乙基磷酰胆碱是分泌型磷脂酶A2(sPLA2)的抑制剂,参与促炎脂质介质的生物合成。酰氧乙基磷酰胆碱可用于研究炎症性疾病。酰氧乙基磷酰胆碱还修饰了红细胞膜,并被用于结合携带氧气的液体全氟化碳,作为抗蛇毒血清剂,以减少毒素诱导的溶血[1][2]。

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中文名 磷酰胆碱
英文名 oleyloxyethyl phosphorylcholine
英文别名 2-[(9Z)-9-Octadecenoyloxy]ethyl 2-(trimethylammonio)ethyl phosphate
Ethanaminium, 2-[[hydroxy[2-[[(9Z)-1-oxo-9-octadecen-1-yl]oxy]ethoxy]phosphinyl]oxy]-N,N,N-trimethyl-, inner salt
描述 (Z) -酰氧乙基磷酰胆碱((Z)-OPC)是酰氧乙基磷酸胆碱(OPC)的异构体。酰氧乙基磷酰胆碱是分泌型磷脂酶A2(sPLA2)的抑制剂,参与促炎脂质介质的生物合成。酰氧乙基磷酰胆碱可用于研究炎症性疾病。酰氧乙基磷酰胆碱还修饰了红细胞膜,并被用于结合携带氧气的液体全氟化碳,作为抗蛇毒血清剂,以减少毒素诱导的溶血[1][2]。
相关类别
靶点

sPLA2

参考文献

[1]. Hope WC, et al. Secretory phospholipase A2 inhibitors and calmodulin antagonists as inhibitors of cytosolic phospholipase A2. Agents Actions. 1993;39 Spec No:C39-42.  

[2]. Yang Zhe, et al. Oxygen-carrying bionic nano antidote and its preparation method and application in preparation of anti snake venom drug. China, CN113509488 A. 2021-10-19.

分子式 C25H52NO5P
分子量 477.66
精确质量 491.337585
PSA 94.70000
LogP 3.87
储存条件 ?20°C
计算化学

1.疏水参数计算参考值(XlogP):6.8

2.氢键供体数量:1

3.氢键受体数量:5

4.可旋转化学键数量:24

5.互变异构体数量:无

6.拓扑分子极性表面积65

7.重原子数量:32

8.表面电荷:1

9.复杂度:479

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:1

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

Version 1.2
Regulation (EC) No 1907/2006

1 - Product and Company Information

Product NamePHOSPHORYLCHOLINE, OLEOYLOXYETHYL ESTER

2 - Hazards Identification

3 - Composition/Information on Ingredients

Product NameCAS #EC noAnnex I
Index Number
PHOSPHORYLCHOLINE, OLEOYLOXYETHYL 84601-19-4 NoneNone
ESTER
FormulaC25H52NO5P
Molecular Weight 477,7000 AMU

4 - First Aid Measures

AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of contact, immediately wash skin with soap and copious
amounts of water.
AFTER EYE CONTACT
In case of contact, immediately flush eyes with copious amounts
of water for at least 15 minutes.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.

5 - Fire Fighting Measures

EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SIGMAwww.molbase.com
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.

6 - Accidental Release Measures

PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear respirator, chemical safety goggles, rubber boots, and
heavy rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.

7 - Handling and Storage

STORAGE
Store at -20°C

8 - Exposure Controls / Personal Protection

ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Use respirators and components tested and
approved under appropriate government standards such as NIOSH (US)
or CEN (EU). Respiratory protection is not required. Where
protection from nuisance levels of dusts are desired, use type N95
(US) or type P1 (EN 143) dust masks.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.

9 - Physical and Chemical Properties

AppearancePhysical State: Solid
PropertyValueAt Temperature or Pressure
pHN/A
BP/BP RangeN/A
MP/MP RangeN/A
Flash PointN/A
FlammabilityN/A
Autoignition TempN/A
Oxidizing PropertiesN/A
Explosive PropertiesN/A
Explosion LimitsN/A
Vapor PressureN/A
Partition CoefficientN/A
ViscosityN/A
Vapor DensityN/A
SIGMAwww.molbase.com
Saturated Vapor Conc. N/A
Evaporation RateN/A
Bulk DensityN/A
Decomposition Temp.N/A
Solvent ContentN/A
Water ContentN/A
Surface TensionN/A
ConductivityN/A
Miscellaneous DataN/A
SolubilityN/A

10 - Stability and Reactivity

STABILITY
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides, Phosphorous oxides.

11 - Toxicological Information

SIGNS AND SYMPTOMS OF EXPOSURE
To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Eye Contact: May cause eye irritation.
Inhalation: Material may be irritating to mucous membranes and
upper respiratory tract.
Multiple Routes: May be harmful by inhalation, ingestion, or
skin absorption.

12 - Ecological Information

No data available.

13 - Disposal Considerations

SUBSTANCE DISPOSAL
Dissolve or mix the material with a combustible solvent and burn
in a chemical incinerator equipped with an afterburner and
scrubber. Observe all federal, state, and local environmental
regulations.

14 - Transport Information

RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.

15 - Regulatory Information

Caution: Substance not yet fully tested (EU).
SIGMAwww.molbase.com
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 3
Self-Classification

16 - Other Information

WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2010 Co. License granted to make
unlimitedpaper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
SIGMAwww.molbase.com


SECTION 16 - ADDITIONAL INFORMATION
N/A