CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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SO4375000
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CHEMICAL NAME :
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Phenothiazine, 10-(2-(diethylamino)ethyl)-, monohydrochloride
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CAS REGISTRY NUMBER :
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341-70-8
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LAST UPDATED :
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199706
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DATA ITEMS CITED :
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9
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MOLECULAR FORMULA :
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C18-H22-N2-S .Cl-H
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MOLECULAR WEIGHT :
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334.94
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WISWESSER LINE NOTATION :
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T C666 BN ISJ B2N2&2 &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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200 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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450 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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225 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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450 mg/kg
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TOXIC EFFECTS :
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Vascular - BP lowering not characterized in autonomic section
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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5 mg/kg
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TOXIC EFFECTS :
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Vascular - BP lowering not characterized in autonomic section
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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150 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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2500 ug/kg
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TOXIC EFFECTS :
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Vascular - BP lowering not characterized in autonomic section
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - guinea pig
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DOSE/DURATION :
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450 mg/kg
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TOXIC EFFECTS :
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Autonomic Nervous System - parasympatholytic
MUTATION DATA
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TYPE OF TEST :
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DNA adduct
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TEST SYSTEM :
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Bacteria - Escherichia coli
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DOSE/DURATION :
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20 umol/L
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REFERENCE :
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MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 89,95,1981
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