7644-67-9

• 常用中文名：含氮霉素
• 常用英文名：L-Norleucine, L-g-glutamyl-6-diazo-5-oxo-L-norleucyl-6-diazo-5-oxo-
• CAS号：7644-67-9
• 分子式：C₁₇H₂₃N₇O₈
• 分子量：453.40700
• 相关类别： 原料药 抗肿瘤药 抗生素类抗肿瘤药
• 发布时间：2018-08-16 16:02:46
• 更新时间：2024-01-10 16:10:51

名称

• 中文名: 含氮霉素
• 英文名: Diazomycin B
• 中文别名: 阿佐霉素
• 英文别名: Antibiotic produced by streptomyces ambofaciens; Azotomycin; Azotomycin sodium salt; DuazomycinB; Antibiotic-1719

物化性质

• 密度: 1.2516 (rough estimate)
• 沸点: 560.56°C (rough estimate)
• 分子式: C₁₇H₂₃N₇O₈
• 分子量: 453.40700
• 精确质量: 453.16100
• PSA: 267.74000
• 折射率: 1.6800 (estimate)
• 储存条件: 通风低温干燥,与库房食品原料分开存放

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : RC6310000 CHEMICAL NAME : L-Norleucine, 6-diazo-N-(6-diazo-N-L-gamma-glutamyl-5-oxo-L-norleuc yl)-5-oxo- CAS REGISTRY NUMBER : 7644-67-9 LAST UPDATED : 199707 DATA ITEMS CITED : 12 MOLECULAR FORMULA : C17-H23-N7-O8 MOLECULAR WEIGHT : 453.47 WISWESSER LINE NOTATION : QVYZ2VMY2V1UNN&VMYVQ2V1UNN HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Human DOSE/DURATION : 192 mg/kg/4D TOXIC EFFECTS : Gastrointestinal - nausea or vomiting Blood - changes in bone marrow (not otherwise specified) TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 105 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 27 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 31 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 99 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 100 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 8 mg/kg/6W-I TOXIC EFFECTS : Liver - other changes Endocrine - changes in adrenal weight Nutritional and Gross Metabolic - weight loss or decreased weight gain TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 550 ug/kg/15D-I TOXIC EFFECTS : Liver - other changes Endocrine - changes in adrenal weight Nutritional and Gross Metabolic - weight loss or decreased weight gain TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 6 mg/kg/8W-I TOXIC EFFECTS : Gastrointestinal - hypermotility, diarrhea Gastrointestinal - nausea or vomiting Nutritional and Gross Metabolic - weight loss or decreased weight gain TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 66 mg/kg/4W-I TOXIC EFFECTS : Endocrine - hyperglycemia Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - weight loss or decreased weight gain MUTATION DATA TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Rodent - mouse Ascites tumor DOSE/DURATION : 400 ug/L REFERENCE : NEOLA4 Neoplasma. (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland) V.4- 1957- Volume(issue)/page/year: 22,105,1975

合成路线

99901-77-6 ~63% 7644-67-9

文献：Pettit; Nelson Journal of Organic Chemistry, 1986 , vol. 51, # 8 p. 1282 - 1286

23403-47-6 ~% 7644-67-9

文献：Pettit; Nelson Journal of Organic Chemistry, 1986 , vol. 51, # 8 p. 1282 - 1286

99901-74-3 ~% 7644-67-9

文献：Pettit; Nelson Journal of Organic Chemistry, 1986 , vol. 51, # 8 p. 1282 - 1286

99901-75-4 ~% 7644-67-9

文献：Pettit; Nelson Journal of Organic Chemistry, 1986 , vol. 51, # 8 p. 1282 - 1286