841-73-6

• 常用中文名：5-Butyl-1-cyclohexylbarbituric acid
• 常用英文名：Bucolome
• CAS号：841-73-6
• 分子式：C₁₄H₂₂N₂O₃
• 分子量：266.33600
• 相关类别： 原料药 解热镇痛药 非甾抗炎药
• 发布时间：2018-10-04 12:03:25
• 更新时间：2024-01-19 19:23:21
• Bucolome 是一种 CYP2C9 抑制剂，为有效的排尿酸药和抗炎药。

名称

• 中文名: 丁基环已基巴比妥
• 英文名: 5-butyl-1-cyclohexylbarbituric acid
• 中文别名: 5-丁基-1-环己基-1,3-二氮杂烷-2,4,6-三酮; 丁环已嘧三酮
• 英文别名: 5-butyl-1-cyclohexyl-pyrimidine-2,4,6-trione; 5-butyl-1-cyclohexyl-1,3-diazinane-2,4,6-trione; Paramidin; bucolome; Bucolom; EINECS 212-666-1; Paramidine; 1-Cyclohexyl-5-butylbarbitursaeure; 5-Butyl-1-cyclohexylbarbituric acid

物化性质

• 密度: 1.139 g/cm3
• 沸点: bp0.8 185-187°
• 熔点: 84°
• 分子式: C₁₄H₂₂N₂O₃
• 分子量: 266.33600
• 精确质量: 266.16300
• PSA: 66.48000
• LogP: 2.47060
• 折射率: 1.511
• 储存条件: 库房低温干燥通风

生物活性

• 描述: Bucolome 是一种 CYP2C9 抑制剂,为有效的排尿酸药和抗炎药。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 细胞色素P450
  研究领域 >> 炎症/免疫
• 体外研究: 布可洛姆是一种有效的(S)-华法林7-羟基化的混合型抑制剂,Ki分别为8.2μM和20.2μM[1]。
• 参考文献:

  [1]. Takahashi H, et al. Pharmacokinetic interaction between warfarin and a uricosuric agent, bucolome: application of In vitro approaches to predicting In vivo reduction of (S)-warfarin clearance. Drug Metab Dispos. 1999 Oct;27(10):1179-86.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : CQ1497900 CHEMICAL NAME : Barbituric acid, 5-butyl-1-cyclohexyl- CAS REGISTRY NUMBER : 841-73-6 BEILSTEIN REFERENCE NO. : 0755320 LAST UPDATED : 199612 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C14-H22-N2-O3 MOLECULAR WEIGHT : 266.38 WISWESSER LINE NOTATION : T6VMVNV FHJ F4 D- AL6TJ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1115 mg/kg TOXIC EFFECTS : Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea REFERENCE : NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 63,43,1967 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 455 mg/kg TOXIC EFFECTS : Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea REFERENCE : NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 63,43,1967 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1550 mg/kg TOXIC EFFECTS : Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea REFERENCE : NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 63,43,1967 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 550 mg/kg TOXIC EFFECTS : Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea REFERENCE : NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 63,43,1967 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 2800 mg/kg SEX/DURATION : female 7-13 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) REFERENCE : JJPAAZ Japanese Journal of Pharmacology. (Japanese Pharmacological Soc., c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto 606, Japan) V.1- 1951- Volume(issue)/page/year: 17,381,1967 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 25200 mg/kg SEX/DURATION : male 36 week(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) REFERENCE : NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 63,105,1967

安全

• 海关编码: 2933540000

海关

海关编码	2933540000
中文概述	2933540000 其他丙二酰脲（巴比土酸）的衍生物以及它们的盐。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933540000 other derivatives of malonylurea (barbituric acid); salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:20.0%