63935-38-6

• 常用中文名：乙氰菊酯
• 常用英文名：CYCLOPROTHRIN
• CAS号：63935-38-6
• 分子式：C₂₆H₂₁Cl₂NO₄
• 分子量：482.35500
• 相关类别： 化学农药原药 杀虫剂 拟除虫菊脂杀虫剂
• 发布时间：2018-09-04 19:07:11
• 更新时间：2024-01-05 22:21:25

• 拟除虫菊酯类杀虫剂，具有触杀活性，无胃毒作用，能抑制产卵。用于防治斜纹夜蛾、二化螟、稻象甲、黑尾叶蝉、小菜蛾、桃蚜、稻根象等多种害虫。如防治甘蓝、白菜上的菜青虫、小菜蛾、蚜虫等，使用100～250mg/L喷雾；如用于水稻，施药量1.5～2g/100m2。

名称

• 中文名: 乙氰菊酯
• 英文名: cycloprothrin
• 中文别名: α-氰基-3'-苯氧基苄基(RS)-2,2-氯-1-(4-乙氧苯基)-2,2-二氯环丙烷羧酸酯; 赛乐收; 杀螟菊酯; (RS)-Α-氰基-3-苯氧苄基-(RS)-2,2-二氯-1(4-乙氧基苯基)环丙烷羧酸; 稻虫菊酯; 乙腈菊酯
• 英文别名: (RS)-α-cyano-3-phenoxybenzyl (RS)-2,2-dichloro-1-(4-ethoxyphenyl)cyclopropanecarboxylate; Cyclosal; Phencyclate; GH 414; Cyclosal (insecticide); [cyano-(3-phenoxyphenyl)methyl] 2,2-dichloro-1-(4-ethoxyphenyl)cyclopropane-1-carboxylate; Cycloprothrin [ISO]; (Ξ)-cyano(3-phenoxyphenyl)methyl (1Ξ)-2,2-dichloro-1-(4-ethoxyphenyl)cyclopropane-1-carboxylate; cyano-(3-phenoxyphenyl)methyl 2,2-dichloro-1-(4-ethoxyphenyl)cyclopropane carboxylate; Cycloprothrin; cyano(3-phenoxyphenyl)methyl 2,2-dichloro-1-(4-ethoxyphenyl)cyclopropanecarboxylate; NK 8116; 2,2-Dichloro-1-(4-ethoxyphenyl)cyclopropanecarboxylic acid cyano(3-phenoxyphenyl)methyl ester

物化性质

• 密度: 1.36g/cm3
• 沸点: 608.7ºC at 760 mmHg
• 熔点: <25℃
• 分子式: C₂₆H₂₁Cl₂NO₄
• 分子量: 482.35500
• 闪点: 321.9ºC
• 精确质量: 481.08500
• PSA: 68.55000
• LogP: 6.50108
• 折射率: 1.633
• 储存条件: 0-6°C
• 分子结构:

  1、 摩尔折射率：126.11

  2、 摩尔体积（cm³/mol）：353.0

  3、 等张比容（90.2K）：982.7

  4、 表面张力（dyne/cm）：60.0

  5、 极化率（10^-24cm³）：49.99

• 计算化学:

  1.疏水参数计算参考值（XlogP）:6.2

  2.氢键供体数量:0

  3.氢键受体数量:5

  4.可旋转化学键数量:9

  5.互变异构体数量:无

  6.拓扑分子极性表面积68.6

  7.重原子数量:33

  8.表面电荷:0

  9.复杂度:723

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:2

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

• 更多:

  1. 性状：透明粘性液体。

  2. 密度（g/mL,25/4℃）：1.256

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC）：140~145

  5. 沸点（ºC,常压）：未确定

  6. 沸点（ºC,5.2kPa）：未确定

  7. 折射率：未确定

  8. 闪点（ºC）：未确定

  9. 比旋光度（º）：未确定

  10. 自燃点或引燃温度（ºC）：未确定

  11. 蒸气压（kPa,25ºC）：未确定

  12. 饱和蒸气压（kPa,60ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性：未确定。

毒性和生态

毒理学数据: 1、急性毒性：大鼠（口服）LD50：＞5mg/kg 大鼠（吸入）LC50： 1,500 mg/m3 大鼠（皮上）LD50：＞2 mg/kg 小鼠（口服）LD50：＞5mg/kg 鸡（口服）LD50：＞2 mg/kg 鹌鹑（口服）LD50：＞5mg/kg 鸟（口服）LD50： 2 mg/kg 由于食盐的LD50是3,000 mg/kg，BPA的急性毒性程度与食盐同。 CHEMICAL IDENTIFICATION RTECS NUMBER : GZ1251800 CHEMICAL NAME : Cyclopropanecarboxylic acid, 2,2-dichloro-1-(4-ethoxyphenyl)-, cyano(3-phenoxyphenyl) methyl ester CAS REGISTRY NUMBER : 63935-38-6 LAST UPDATED : 199207 DATA ITEMS CITED : 11 MOLECULAR FORMULA : C26-H21-Cl2-N-O4 MOLECULAR WEIGHT : 482.38 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >5 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP. Volume(issue)/page/year: (53),22,1988 TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1500 mg/m3 TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP. Volume(issue)/page/year: (53),22,1988 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP. Volume(issue)/page/year: (53),22,1988 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >5 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP. Volume(issue)/page/year: (53),22,1988 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Bird - chicken DOSE/DURATION : >2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP. Volume(issue)/page/year: (53),22,1988 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Bird - quail DOSE/DURATION : >5 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP. Volume(issue)/page/year: (53),22,1988 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Bird - domestic DOSE/DURATION : 2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year: -,C89,1991 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1699 mg/kg/13W-C TOXIC EFFECTS : Liver - other changes Kidney, Ureter, Bladder - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase REFERENCE : NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 16,697,1991 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 82264 mg/kg/2Y-C TOXIC EFFECTS : Behavioral - food intake (animal) Kidney, Ureter, Bladder - other changes Endocrine - adrenal cortex hyperplasia REFERENCE : NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 16,697,1991 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 485 gm/kg/80W-C TOXIC EFFECTS : Liver - other changes Kidney, Ureter, Bladder - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases REFERENCE : NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 16,697,1991 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 9100 mg/kg/26W-C TOXIC EFFECTS : Brain and Coverings - other degenerative changes Liver - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 16,697,1991

安全

• 危害码 (欧洲): Xi
• 风险声明 (欧洲): R36/37/38
• 安全声明 (欧洲): S26
• 危险品运输编码: UN 3077 9 / PGIII
• 海关编码: 29269090

制备

1 1-(4-乙氧基苯基)-2,2-二氯环丙烷羧酰氯的制备

2 3-苯氧基-α-氰基苯甲醇的制备

3乙氰菊酯的合成