174575-17-8

• 常用中文名：(S)-ALPHA-氨基-2'-氯-5-(膦酰基甲基)-[1,1'-联苯]-3-丙酸
• 常用英文名：SDZ 220-581
• CAS号：174575-17-8
• 分子式：C₁₆H₁₇ClNO₅P
• 分子量：369.737
• 相关类别： 信号通路 跨膜转运 iGluR
• 发布时间：2018-12-22 20:18:54
• 更新时间：2024-01-08 18:12:07
• SDZ 220-581是竞争性NMDA谷氨酸受体亚型拮抗剂,pKi为7.7。

名称

• 中文名: (S)-ALPHA-氨基-2'-氯-5-(膦酰基甲基)-[1,1'-联苯]-3-丙酸
• 英文名: SDZ 220-581,(S)-α-Amino-2'-chloro-5-(phosphonomethyl)[1,1'-biphenyl]-3-propanoicacid
• 英文别名: (2S)-2-Amino-3-[2'-chloro-5-(phosphonomethyl)-3-biphenylyl]propanoic acid; sdz 220-581

物化性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 613.3±65.0 °C at 760 mmHg
• 分子式: C₁₆H₁₇ClNO₅P
• 分子量: 369.737
• 闪点: 324.7±34.3 °C
• 精确质量: 369.053284
• PSA: 130.66000
• LogP: 0.89
• 蒸汽压: 0.0±1.9 mmHg at 25°C
• 折射率: 1.637
• 储存条件: 2-8℃

生物活性

• 描述: SDZ 220-581是竞争性NMDA谷氨酸受体亚型拮抗剂,pKi为7.7。
• 相关类别:
  信号通路 >> 跨膜转运 >> iGluR
  信号通路 >> 神经信号通路 >> iGluR
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Gilmour G, Broad LM, Wafford KA, In vitro characterisation of the novel positive allosteric modulators of the mGlu? receptor, LSN2463359 and LSN2814617, and their effects on sleep architecture and operant responding in the rat. Neuropharmacology. 2013 Jan

  [2]. Linderholm K, Powell S, Olsson E, Role of the NMDA-receptor in Prepulse Inhibition in the Rat. Int J Tryptophan Res. 2010;3:1-12.

  [3]. Urwyler S, Campbell E, Fricker G, Biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a novel class of potent competitive N-methyl-D-aspartate receptor antagonists--II. Pharmacological characterization in vivo. Neuropharmacology. 1996 Jun;35(6):65

  [4]. Bakshi VP, Tricklebank M, Neijt HC, Disruption of prepulse inhibition and increases in locomotor activity by competitive N-methyl-D-aspartate receptor antagonists in rats. J Pharmacol Exp Ther. 1999 Feb;288(2):643-52.