390-64-7

• 常用中文名：普尼拉明
• 常用英文名：prenylamine
• CAS号：390-64-7
• 分子式：C₂₄H₂₇N
• 分子量：329.48
• 相关类别： 原料药 循环系统用药 防治心绞痛药
• 发布时间：2018-04-21 08:00:00
• 更新时间：2024-01-03 15:31:36
• Prenylamine 是一种苯丙胺化学类别的钙通道阻滞剂。 Prenylamine 可作为血管扩张剂,可用于心绞痛的研究。

名称

• 中文名: 普尼拉明
• 英文名: 3,3-diphenyl-N-(1-phenylpropan-2-yl)propan-1-amine
• 英文别名: Synadrin; Elecor; Hostaginan; Prenylamine; Valecor; Segontin; Corpax; Falliocor; Bismethin; DL-Prenylamine

物化性质

• 密度: 1.023g/cm3
• 沸点: 476.1ºC at 760mmHg
• 熔点: 36.5-37.5°
• 分子式: C₂₄H₂₇N
• 分子量: 329.48
• 闪点: 219.4ºC
• 精确质量: 329.21400
• PSA: 12.03000
• LogP: 5.82030
• 折射率: 1.577
• 储存条件: Refrigerator

生物活性

• 描述: Prenylamine 是一种苯丙胺化学类别的钙通道阻滞剂。 Prenylamine 可作为血管扩张剂,可用于心绞痛的研究。
• 相关类别:
  信号通路 >> 跨膜转运 >> 钙通道
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. Nielsen KC, et al. Control of ventricular fibrillation during induced hypothermia in cats after differential depletion of cardiac catecholamine stores with prenylamine (Segontin). Circ Res. 1967 Jul;21(1):45-58.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : SH6480000 CHEMICAL NAME : Phenethylamine, N-(3,3-diphenylpropyl)-alpha-methyl- CAS REGISTRY NUMBER : 390-64-7 LAST UPDATED : 199612 DATA ITEMS CITED : 15 MOLECULAR FORMULA : C24-H27-N MOLECULAR WEIGHT : 329.52 WISWESSER LINE NOTATION : RYR&2MY1&1R HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 13 mg/kg TOXIC EFFECTS : Behavioral - muscle weakness Cardiac - pulse rate REFERENCE : ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN. Volume(issue)/page/year: 31,217,1974 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 50 mg/kg/2W-I TOXIC EFFECTS : Cardiac - pulse rate increase, without fall in BP REFERENCE : LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 2,572,1986 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 2816 mg/kg/3Y-I TOXIC EFFECTS : Behavioral - tremor REFERENCE : BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 288,1048,1984 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 250 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 21PFAR "Conferentia Hungarica pro Therapia et Investigatione in Pharmacologia, Societas Pharmacologyica Hungarica, 4th, Budapest, 1966," Dumbovich, B., ed., Budapest, Hungary, Akademiai Kiado, 1968 Volume(issue)/page/year: 4,167,1968 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 44 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - acute pulmonary edema Lungs, Thorax, or Respiration - other changes REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 10,569,1960 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 11 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 20,1362,1970 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 39 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CHTPBA Chimica Therapeutica. (Paris, France) V.1-8, 1965-73. For publisher information, see EJMCA5. Volume(issue)/page/year: 2,366,1967 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 230 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - acute pulmonary edema Lungs, Thorax, or Respiration - other changes REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 10,569,1960 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 250 mg/kg TOXIC EFFECTS : Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis) REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 6,676,1964 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 900 mg/kg/30D-C TOXIC EFFECTS : Endocrine - changes in adrenal weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death REFERENCE : GNRIDX Gendai no Rinsho. (Tokyo, Japan) V.1-10, 1967-76(?). Volume(issue)/page/year: 5,256,1971 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 4680 mg/kg/26W-I TOXIC EFFECTS : Cardiac - changes in heart weight Related to Chronic Data - death Related to Chronic Data - changes in testicular weight REFERENCE : GNRIDX Gendai no Rinsho. (Tokyo, Japan) V.1-10, 1967-76(?). Volume(issue)/page/year: 5,256,1971 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 60 mg/kg SEX/DURATION : female 9-14 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : GNRIDX Gendai no Rinsho. (Tokyo, Japan) V.1-10, 1967-76(?). Volume(issue)/page/year: 5,271,1971 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 270 mg/kg SEX/DURATION : female 7-12 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) REFERENCE : GNRIDX Gendai no Rinsho. (Tokyo, Japan) V.1-10, 1967-76(?). Volume(issue)/page/year: 5,271,1971 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 30 mg/kg SEX/DURATION : female 7-12 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : GNRIDX Gendai no Rinsho. (Tokyo, Japan) V.1-10, 1967-76(?). Volume(issue)/page/year: 5,271,1971 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 180 mg/kg SEX/DURATION : female 7-12 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) REFERENCE : GNRIDX Gendai no Rinsho. (Tokyo, Japan) V.1-10, 1967-76(?). Volume(issue)/page/year: 5,271,1971

安全

• 海关编码: 2921499090

合成路线

2286-54-6 60-15-1 ~% 390-64-7

文献：Kerr, David I. B.; Ong, Jennifer; Perkins, Michael V.; Prager, Rolf H.; Puspawati, Ni Made Australian Journal of Chemistry, 2006 , vol. 59, # 7 p. 445 - 456

29648-95-1 60-15-1 ~% 390-64-7

文献：Taube, D. O.; Lukinskaya, E. P.; Passet, B. V. Pharmaceutical Chemistry Journal, 1980 , vol. 14, # 1 p. 50 - 54 Khimiko-Farmatsevticheskii Zhurnal, 1980 , vol. 14, # 1 p. 62 - 67

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海关

海关编码	2921499090
中文概述	2921499090 其他芳香单胺及衍生物及它们的盐. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%