9002-92-0

• 常用中文名：月桂醇聚氧乙烯醚
• 常用英文名：Polyoxyethylene lauryl ether
• CAS号：9002-92-0
• 分子式：(C₂H₄O)nC₁₂H₂₆O
• 分子量：1199.543
• 相关类别： 表面活性剂 非离子表面活性剂 多元醇酯型
• 发布时间：2018-02-06 08:00:00
• 更新时间：2024-01-02 11:57:38
• Polidocanol 是一种硬化剂,可用于肢体和食管静脉曲张和毛细血管扩张的研究。

名称

• 中文名: 月桂醇聚氧乙烯醚
• 英文名: Polyoxyethylene lauryl ether
• 中文别名: 平平加O-20; 聚氧乙烯月桂醚; 四聚乙二醇单月桂醚; 月桂醇聚; 聚乙二醇单十二烷醚; 匀染剂O; 平平加O
• 英文别名: depeg; EINECS 500-002-6; la7; g3711; ped; bl9; do9; g3707; polyoxethyleneglycol-23 lauryl ether; bl9ex; Polidocanol (PEG Monododecyl Ether); yx500; AEO4; MFCD00080891; Brij 35; Polidocanol

物化性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 960.0±60.0 °C at 760 mmHg
• 熔点: 41-45 °C(lit.)
• 分子式: (C₂H₄O)nC₁₂H₂₆O
• 分子量: 1199.543
• 闪点: 534.4±32.9 °C
• 精确质量: 1198.801270
• PSA: 232.52000
• LogP: -2.83
• 外观性状: 透明油性液体
• 蒸汽压: 0.0±0.6 mmHg at 25°C
• 折射率: 1.465
• 储存条件:

  常温密闭，避光，通风干燥处

• 稳定性:

  常温常压下稳定

  避免光，明火，高温
• 水溶解性: 可溶
• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:1

  3.氢键受体数量:2

  4.可旋转化学键数量:13

  5.互变异构体数量:无

  6.拓扑分子极性表面积29.5

  7.重原子数量:16

  8.表面电荷:0

  9.复杂度:115

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

• 更多:

  1. 性状：白色膏状流体

  2. 密度（g/mL,20℃）： 0.950-0.965

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC）：41-45

  5. 沸点（ºC,常压）：100

  6. 沸点（ºC,5.2kPa）：未确定

  7. 折射率：1.461

  8. 闪点（ºC）： 190

  9. 比旋光度（º）：未确定

  10. 自燃点或引燃温度（ºC）：>110

  11. 蒸气压（kPa,25ºC）：0.133

  12. 饱和蒸气压（kPa,60ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性：溶于水溶解度为：40mg/mL at20°C

生物活性

• 描述: Polidocanol 是一种硬化剂,可用于肢体和食管静脉曲张和毛细血管扩张的研究。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 心血管疾病
• 体内研究: 聚二醇(0.5％,1％和2％)导致比四环素显着更多的粘连,而稀释的聚多卡醇的作用类似于大鼠中四环素的作用。聚乙二醇浓度较高,0.5％,1％和2％比稀释的聚多卡醇或四环素对胸膜固定术更有效[1]。
• 参考文献:

  [1]. Cetin B, et al. Polidocanol at different concentrations for pleurodesis in rats. Surg Today. 2005;35(12):1066-9.

MSDS

Name: BRIJ 35 30% w/v solution in water Material Safety Data Sheet Synonym: None Known CAS: 9002-92-0 Section 1 - Chemical Product MSDS Name:BRIJ 35 30% w/v solution in water Material Safety Data Sheet Synonym:None Known Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 9002-92-0 BRIJ 35, 30% w/v solution in water unlisted Hazard Symbols: None Listed. Risk Phrases: None Listed. Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW The toxicological properties of this material have not been fully investigated. Potential Health Effects Eye: May cause eye irritation. Skin: May cause skin irritation. May be harmful if absorbed through the skin. Ingestion: May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated. May be harmful if swallowed. Inhalation: May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated. May be harmful if inhaled. Chronic: No information found. Section 4 - FIRST AID MEASURES Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Ingestion: If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid. Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Treat symptomatically and supportively. Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Clean up spills immediately, observing precautions in the Protective Equipment section. Provide ventilation. Section 7 - HANDLING and STORAGE Handling: Wash thoroughly after handling. Use with adequate ventilation. Avoid breathing dust, vapor, mist, or gas. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Storage: Store in a cool, dry place. Store in a tightly closed container. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 9002-92-0: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Liquid Color: clear Odor: Not available. pH: 5-7 Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: Not available. Autoignition Temperature: Not available. Flash Point: 235 deg F ( 112.78 deg C) Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: Soluble. Specific Gravity/Density: 1.03 Molecular Formula: Solution Molecular Weight: 0 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable at room temperature in closed containers under normal storage and handling conditions. Conditions to Avoid: Excess heat. Incompatibilities with Other Materials: Strong oxidizing agents. Hazardous Decomposition Products: Carbon monoxide, carbon dioxide. Hazardous Polymerization: Has not been reported Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 9002-92-0: JR5960000 JR5970000 JR5990000 MD0875000 LD50/LC50: CAS# 9002-92-0: Draize test, rabbit, eye: 10 mg; Draize test, rabbit, eye: 100 mg; Draize test, rabbit, eye: 750 ug/24H Severe; Draize test, rabbit, skin: 100 mg; Draize test, rabbit, skin: 500 mg/24H Mild; Draize test, rabbit, skin: 75 mg/24H Mild; Draize test, rabbit, skin: 500 mg/24H Moderate; Oral, mouse: LD50 = 4940 mg/kg; Oral, mouse: LD50 = 1170 mg/kg; Oral, mouse: LD50 = 3500 mg/kg; Oral, mouse: LD50 = 1170 mg/kg; Oral, rat: LD50 = 8600 mg/kg; Oral, rat: LD50 = 4150 mg/kg; Oral, rat: LD50 = 8600 mg/kg; Oral, rat: LD50 = 1 gm/kg. Carcinogenicity: BRIJ 35, 30% w/v solution in water - Not listed by ACGIH, IARC, or NTP. Other: See actual entry in RTECS for complete information. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Not regulated as a hazardous material. IMO Not regulated as a hazardous material. RID/ADR Not regulated as a hazardous material. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: Not available. Risk Phrases: Safety Phrases: S 24/25 Avoid contact with skin and eyes. WGK (Water Danger/Protection) CAS# 9002-92-0: 2 Canada CAS# 9002-92-0 is listed on Canada's DSL List. CAS# 9002-92-0 is listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 9002-92-0 is listed on the TSCA inventory. SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

毒理学数据: 急性毒性： 大鼠经口LD50： 8600 mg/kg； 大鼠皮下LD50： 954 mg/kg 大鼠注射LD50： 27 mg/kg； 小鼠经口LC50： 4940 mg/kg 小鼠腹腔LC50： 160 mg/kg； 小鼠皮下LC50： 192 mg/ kg 小鼠注射LC50： 100 mg/kg； 生态学数据: 通常对水是稍微危害的，不要将未稀释或大量产品接触地下水，水道或者污水系统。若无政府许可，勿将材料排入周围环境。 CHEMICAL IDENTIFICATION RTECS NUMBER : JR5990000 CHEMICAL NAME : Dodecyl alcohol condensed with 23 moles ethylene oxide CAS REGISTRY NUMBER : 9002-92-0 LAST UPDATED : 199710 DATA ITEMS CITED : 6 WISWESSER LINE NOTATION : T3OTJ 23 &Q12 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 8600 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : SPCOAH Soap, Perfumery & Cosmetics. (London, UK) V.8(7)-48(2), 1935-75. Volume(issue)/page/year: 38,47,1965 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : APRCAS American Perfumer and Cosmetics. (Oak Park, IL) V.77-86, 1962-71. For publisher information, see CSPEAX. Volume(issue)/page/year: 77,35,1962 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - A1179 No. of Facilities: 3288 (estimated) No. of Industries: 33 No. of Occupations: 37 No. of Employees: 43764 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - A1179 No. of Facilities: 5821 (estimated) No. of Industries: 32 No. of Occupations: 40 No. of Employees: 104035 (estimated) No. of Female Employees: 60645 (estimated)

安全

• 符号: GHS05, GHS07
• 信号词: Danger
• 危害声明: H302-H315-H318
• 警示性声明: P280-P305 + P351 + P338
• 个人防护装备: dust mask type N95 (US);Eyeshields;Gloves
• 危害码 (欧洲): Xn:Harmful
• 风险声明 (欧洲): R22;R36/37/38
• 安全声明 (欧洲): 26-39-37/39-36/37/39-36-24/25
• 危险品运输编码: UN 3082 9/PG 3
• WGK德国: 3
• RTECS号: MD0875000
• 海关编码: 34021300

制备

1.1 mol C_12～18脂肪醇在固碱催化下与20 mol环氧乙烷缩合。反应在管式反应器中进行。反应器的前部分为264根5.5 m长、16 mm口径的钢管，后部分为58根长5.5 m、25.4 mm的钢管组成。各管间用U形环连成串联形式。其中16 mm的管共长1 448 mm，25.4 mm管共长318 mm。16 mm管的前部为预热区，其余部分为反应区，25.4 mm的管全部为浸渍区。全部管放在一个密封的水槽中。通过管和控制器维持进入水槽中一定数量的热水，反应室内的温度维持在120～140℃。此温度由压力控制调节器控制。水槽一端的盖上有许多环氧乙烷进料口，进料口与环氧乙烷贮罐相连。
具体操作是将固体催化剂加入供料罐中，熔化的脂肪醇用泵打入供料罐中，两种原料在供料罐中混匀后打入反应室的预热部分。当温度升至50～70℃时，环氧乙烷从贮罐压入各加料口进入反应室。经取料测浊点（1%水溶液）达到75℃左右反应终止。反应液进入中和釜，用冰醋酸调pH值至5.0～7.0，然后加入双氧水漂白脱色，冷却到50℃以下，放料包装即为成品。

海关

海关编码	34021300