969-99-3

• 常用中文名：氧氯丙嗪
• 常用英文名：Oxychlorpromazine
• CAS号：969-99-3
• 分子式：C₁₇H₁₉ClN₂OS
• 分子量：334.86400
• 相关类别： 分析化学 标准品 药典标准品和杂志标准品
• 发布时间：2018-03-12 08:00:00
• 更新时间：2024-01-02 11:47:21

名称

• 中文名: 氧氯丙嗪
• 英文名: 3-(2-chloro-5-oxophenothiazin-10-yl)-N,N-dimethylpropan-1-amine
• 英文别名: Chlorpromazine sulphoxide; Opromazine; Chlorpromazine-S-oxyd; Oxychlorpromazine; Chloropromazine sulfoxide; Opromazin; Transedon; Chlorpromazine sulfoxide; Chlorpromazine-S-oxide; Secotil

物化性质

• 密度: 1.35g/cm3
• 沸点: 502.6ºC at 760 mmHg
• 熔点: 115°
• 分子式: C₁₇H₁₉ClN₂OS
• 分子量: 334.86400
• 闪点: 257.8ºC
• 精确质量: 334.09100
• PSA: 42.76000
• LogP: 4.84060
• 折射率: 1.687

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : SO2275000 CHEMICAL NAME : Phenothiazine, 2-chloro-10-(3-(dimethylamino)propyl)-, sulfoxide CAS REGISTRY NUMBER : 969-99-3 BEILSTEIN REFERENCE NO. : 0307255 LAST UPDATED : 199612 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C17-H19-Cl-N2-O-S MOLECULAR WEIGHT : 334.89 WISWESSER LINE NOTATION : T C666 BN ISJ B3N1&1 EG IO HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 163 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 118,328,1956 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 102 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NAIZAM Nara Igaku Zasshi. Journal of the Nara Medical Association. (Nara Igakkai, c/o Narakenritsu Ika Daigaku, Shijo-cho, Kashihara, Nara-ken, Japan) V.1- 1950- Volume(issue)/page/year: 8,50,1957 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 90 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 53,71S,1957

合成路线

50-53-3 ~1% 2095-62-7 3926-66-7 3930-47-0 详细

文献：Slavik, Roger; Peters, Jens-Uwe; Giger, Rudolf; Buerkler, Markus; Bald, Eric Tetrahedron Letters, 2011 , vol. 52, # 7 p. 749 - 752

130-61-0 ~91% 969-99-3

文献：Owens; Juenge; Poklis Journal of Pharmaceutical Sciences, 1989 , vol. 78, # 4 p. 334 - 336

50-53-3 ~83% 969-99-3

文献：Stalder, Romain; Roth, Gregory P. ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 11 p. 1119 - 1123

69-09-0 ~99% 969-99-3

文献：Bosch, Eric; Kochi, Jay K. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995 , # 8 p. 1057 - 1064

109-54-6 ~% 969-99-3

文献：Kano; Fujimoto Pharmaceutical Bulletin, 1957 , vol. 5, p. 393,396

50-53-3 ~% 50-53-3 969-99-3

文献：Wisniewska, Joanna; Rzesnicki, Pawel; Topolski, Adrian Transition Metal Chemistry, 2011 , vol. 36, # 7 p. 767 - 774

上下游产品

上游产品  4
50-53-3 130-61-0 69-09-0 109-54-6
下游产品  1
50-53-3