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116-31-4生产厂家

116-31-4价格

116-31-4

116-31-4结构式
116-31-4结构式
  • 常用中文名:视黄醛
  • 常用英文名:All-trans-retinal
  • CAS号:116-31-4
  • 分子式:C20H28O
  • 分子量:284.436
  • 相关类别: 原料药 维生素类与矿物质类药 维生素AD类药
  • 发布时间:2018-06-20 08:17:06
  • 更新时间:2024-01-02 09:27:58
  • All-trans-retinal是视网膜中主要的维生素A代谢物之一。 在生理条件下,All-trans-retinal 再生为视觉发色团,11-顺式-视黄醛。
  • 视黄醛是眼球发育中重要的信号转导分子,其在脊椎动物的眼球发育中具有多种不同的重要作用。近视是一种发育性疾病,近视眼球巩膜的主动扩张是其伸长的重要机制,而视黄醛可能是调节实验性近视眼球伸长的信使分子,有关视黄醛与实验性近视发生,发展的关系的研究取得一定进展,本研究综述了视黄醛及其核受体,实验性近视眼球的视网膜,脉络膜,巩膜的视黄醛改变以及视黄醛作为传递从视网膜到巩膜的眼球伸长信号的信使分子的研究进展情况。 维A酸在皮肤病中的作用非常广泛,但由于局部刺激,一定程度上限制了其临床应用。视黄醛是天然维A酸的中间代谢产物,具有与维A酸相似的生物学活性,而且皮肤对它的耐受性明显优于维A酸。现综述视黄醛在体内及皮肤中的代谢及其生物学活性和在皮肤科中的应用。
    虽然戒烟能够大大降低患肺癌的危险,但就戒烟20年而言,他们患这种癌症的危险仍然要比从不吸烟者大两倍。美国专家的研究结果显示,对于这类戒烟者来说,每天服用适量的视黄醛(即维生素A视黄醇和视黄酸的衍生物)即可进一步有效减少患肺癌的可能。有关研究报告日前发表在《美国癌症研究院院刊》上。得克萨斯大学M.D. Anderson癌症研究中心的Jonathan M. Kurie医学博士等在该项研究中比较了两种不同的视黄醛对226例已戒烟者肺组织中视黄酸beta受体(RAR beta)的影响,这种受体的减少通常被认为是发生前癌性肿瘤的先兆,实验开始时大约有60%的自愿者RAR beta受体数减少。经过服用视黄醛9-cisRA三个月后(每天两次),发现该组自愿者的RAR beta受体数得到了显著的增加,但服用另一种视黄醛的人却与无效对照组的没有明显差异。此外专家们还认为,视黄醛的这类效应对于那些正在吸烟的人可能会有所不同。

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中文名 视黄醛
英文名 all-trans-retinal
中文别名 全反式视网膜醛
维生素 A 醛
英文别名 Retinal, all-trans-
Retinene1
all--retinal
3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-Nonatetraenal
retinaldehyde
UNII:RR725D715M
all-trans-retinal
-retinal
all trans-Retinal
all-trans-retinaldehyde
trans-Vitamin A aldehyde
Retinene
EINECS 204-135-8
all-trans Retinal
MFCD00001550
Retinal
trans-Retinal
描述 All-trans-retinal是视网膜中主要的维生素A代谢物之一。 在生理条件下,All-trans-retinal 再生为视觉发色团,11-顺式-视黄醛。
相关类别
靶点

Human Endogenous Metabolite

参考文献

[1]. Sawada O, et al. All-trans-retinal induces Bax activation via DNA damage to mediate retinal cell apoptosis. Exp Eye Res. 2014 Jun;123:27-36.

密度 0.9±0.1 g/cm3
沸点 421.4±14.0 °C at 760 mmHg
熔点 61-63°C
分子式 C20H28O
分子量 284.436
闪点 205.4±12.4 °C
精确质量 284.214020
PSA 17.07000
LogP 6.54
外观性状 黄色粉末
蒸汽压 0.0±1.0 mmHg at 25°C
折射率 1.541
储存条件 −20°C
分子结构

五、分子性质数据:

1、 摩尔折射率:94.14

2、 摩尔体积(m3/mol):299.8

3、 等张比容(90.2K):729.9

4、 表面张力(dyne/cm):35.1

5、 极化率(10-24cm3):37.32

计算化学

1、 疏水参数计算参考值(XlogP):6.2

2、 氢键供体数量:0

3、 氢键受体数量:1

4、 可旋转化学键数量:5

5、 互变异构体数量:

6、 拓扑分子极性表面积(TPSA):171

7、 重原子数量:21

8、 表面电荷:0

9、 复杂度:522

10、 同位素原子数量:0

11、 确定原子立构中心数量:0

12、 不确定原子立构中心数量:0

13、 确定化学键立构中心数量:4

14、 不确定化学键立构中心数量:0

15、 共价键单元数量:1

更多

1. 性状:未确定

2. 密度(g/mL,25℃):未确定

3. 相对蒸汽密度(g/mL,空气=1):未确定

4. 熔点(ºC):64-65

5. 沸点(ºC,常压):未确定

6. 沸点(ºC, KPa):未确定

7. 折射率:未确定

8. 闪点(ºC):未确定

9. 比旋光度(º):未确定

10. 自燃点或引燃温度(ºC):未确定

11. 蒸气压(mmHg, ºC):未确定

12. 饱和蒸气压(kPa, ºC):未确定

13. 燃烧热(KJ/mol):未确定

14. 临界温度(ºC):未确定

15. 临界压力(KPa):未确定

16. 油水(辛醇/水)分配系数的对数值:未确定

17. 爆炸上限(%,V/V):未确定

18. 爆炸下限(%,V/V):未确定

19. 溶解性:未确定


SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifiers
Product name: all trans-Retinal
REACH No.: A registration number is not available for this substance as the substance
or its uses are exempted from registration, the annual tonnage does not
require a registration or the registration is envisaged for a later
registration deadline.
CAS-No.: 116-31-4
Relevant identified uses of the substance or mixture and uses advised against
Identified uses: Laboratory chemicals, Manufacture of substances



SECTION 2: Hazards identification
Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008
Acute toxicity, Oral (Category 4), H302
Skin irritation (Category 2), H315
For the full text of the H-Statements mentioned in this Section, see Section 16.
Classification according to EU Directives 67/548/EEC or 1999/45/EC
Xn HarmfulR22, R38
For the full text of the R-phrases mentioned in this Section, see Section 16.
Label elements
Labelling according Regulation (EC) No 1272/2008
Pictogram
Signal wordWarning
Hazard statement(s)
H302Harmful if swallowed.
H315Causes skin irritation.
Precautionary statement(s) none
Supplemental Hazardnone
Statements
Safety data sheet available on request.
Other hazards - none

SECTION 3: Composition/information on ingredients
Substances
Synonyms: Vitamin A aldehyde
Formula: C20H28O
Molecular Weight: 284,44 g/mol
CAS-No.: 116-31-4
EC-No.: 204-135-8
Hazardous ingredients according to Regulation (EC) No 1272/2008
ComponentClassificationConcentration
Retinaldehyde
CAS-No.116-31-4Acute Tox. 4; Skin Irrit. 2;<= 100 %
EC-No.204-135-8H302, H315
Hazardous ingredients according to Directive 1999/45/EC
ComponentClassificationConcentration
Retinaldehyde
CAS-No.116-31-4Xn, R22 - R38<= 100 %
EC-No.204-135-8
For the full text of the H-Statements and R-Phrases mentioned in this Section, see Section 16

SECTION 4: First aid measures
Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Flush eyes with water as a precaution.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in
section 11
Indication of any immediate medical attention and special treatment needed
no data available

SECTION 5: Firefighting measures
Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides
Advice for firefighters
Wear self contained breathing apparatus for fire fighting if necessary.
Further information
no data available

SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure
adequate ventilation. Avoid breathing dust.
For personal protection see section 8.
Environmental precautions
Do not let product enter drains.
Methods and materials for containment and cleaning up
Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed
containers for disposal.
Reference to other sections
For disposal see section 13.

SECTION 7: Handling and storage
Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols.
Provide appropriate exhaust ventilation at places where dust is formed.
For precautions see section 2.2.
Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
Recommended storage temperature: -20 °C
Light sensitive.
Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection
Control parameters
Components with workplace control parameters
Exposure controls
Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and
at the end of workday.
Personal protective equipment
Eye/face protection
Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested
and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
(without touching glove's outer surface) to avoid skin contact with this product. Dispose of
contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
the standard EN 374 derived from it.
Full contact
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Material tested:Dermatril® (KCL 740 / Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Material tested:Dermatril® (KCL 740 / Z677272, Size M)
data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, test method: EN374
If used in solution, or mixed with other substances, and under conditions which differ from EN 374,
contact the supplier of the CE approved gloves. This recommendation is advisory only and must
be evaluated by an industrial hygienist and safety officer familiar with the specific situation of
anticipated use by our customers. It should not be construed as offering an approval for any
specific use scenario.
Body Protection
Complete suit protecting against chemicals, The type of protective equipment must be selected
according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection
For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle respirator.For higher
level protection use type OV/AG/P99 (US) or type ABEK-P2 (EU EN 143) respirator cartridges.
Use respirators and components tested and approved under appropriate government standards
such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Do not let product enter drains.

SECTION 9: Physical and chemical properties
Information on basic physical and chemical properties
a) AppearanceForm: powder
b) Odourno data available
c) Odour Thresholdno data available
d) pHno data available
e) Melting point/freezingMelting point/range: 62 - 64 °C
point
f) Initial boiling point and no data available
boiling range
g) Flash pointno data available
h) Evapouration rateno data available
i) Flammability (solid, gas) no data available
j) Upper/lowerno data available
flammability or
explosive limits
k) Vapour pressureno data available
l) Vapour densityno data available
m) Relative densityno data available
n) Water solubilityno data available
o) Partition coefficient: n- no data available
octanol/water
p) Auto-ignitionno data available
temperature
q) Decompositionno data available
temperature
r) Viscosityno data available
s) Explosive propertiesno data available
t) Oxidizing propertiesno data available
Other safety information
no data available

SECTION 10: Stability and reactivity
Reactivity
no data available
Chemical stability
Stable under recommended storage conditions.
Possibility of hazardous reactions
no data available
Conditions to avoid
no data available
Incompatible materials
Oxidizing agents
Hazardous decomposition products
Other decomposition products - no data available
In the event of fire: see section 5

SECTION 11: Toxicological information
Information on toxicological effects
Acute toxicity
no data available
Skin corrosion/irritation
no data available
Serious eye damage/eye irritation
no data available
Respiratory or skin sensitisation
no data available
Germ cell mutagenicity
mouse
lymphocyte
DNA inhibition
rat
mammary gland
DNA inhibition
Carcinogenicity
IARC:No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
Laboratory experiments have shown teratogenic effects.
Specific target organ toxicity - single exposure
no data available
Specific target organ toxicity - repeated exposure
no data available
Aspiration hazard
no data available
Additional Information
RTECS: VH6407000
Gastrointestinal disturbance, Repeated exposure may cause skin dryness or cracking., Headache

SECTION 12: Ecological information
Toxicity
no data available
Persistence and degradability
no data available
Bioaccumulative potential
no data available
Mobility in soil
no data available
Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
Other adverse effects
no data available

SECTION 13: Disposal considerations
Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or mix the material
with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.
Contaminated packaging
Dispose of as unused product.

SECTION 14: Transport information
UN number
ADR/RID: -IMDG: -IATA: -
UN proper shipping name
ADR/RID: Not dangerous goods
IMDG: Not dangerous goods
IATA:Not dangerous goods
Transport hazard class(es)
ADR/RID: -IMDG: -IATA: -
Packaging group
ADR/RID: -IMDG: -IATA: -
Environmental hazards
ADR/RID: noIMDG Marine pollutant: noIATA: no
Special precautions for user
no data available



SECTION 15 - REGULATORY INFORMATION
N/A


SECTION 16 - ADDITIONAL INFORMATION
N/A

毒理学数据:

1、 致突变:大鼠乳腺DNA抑制:3umol/L

小鼠淋巴细胞DNA抑制:100umol/L

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VH6407000
CHEMICAL NAME :
Retinal, all-trans-
CAS REGISTRY NUMBER :
116-31-4
BEILSTEIN REFERENCE NO. :
1914183
LAST UPDATED :
199701
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C20-H28-O
MOLECULAR WEIGHT :
284.48

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Rodent - mouse Lymphocyte
DOSE/DURATION :
100 umol/L
REFERENCE :
ONCOBS Oncology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.21- 1967- Volume(issue)/page/year: 44,356,1987

符号 GHS07
GHS07
信号词 Warning
危害声明 H302-H315
个人防护装备 dust mask type N95 (US);Eyeshields;Gloves
危害码 (欧洲) Xn: Harmful;
风险声明 (欧洲) 22-38
安全声明 (欧洲) S22-S36/37
危险品运输编码 NONH for all modes of transport
WGK德国 3
RTECS号 VH6407000
海关编码 2912299000

维生素A在经醇脱氢酶及辅酶I、II的催化,形成顺、反两种视黄醛。

海关编码 2912299000
中文概述 2912299000. 其他不含其他含氧基的环醛. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%
申报要素 品名, 成分含量, 用途, 四聚甲醛报明外观
Summary 2912299000. other cyclic aldehydes without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%