1018332-24-5

• 常用中文名：N-boc-顺式-4-n-Fmoc-氨基-d-脯氨酸
• 常用英文名：(2R,4R)-4-(((9H-FLUOREN-9-YL)METHOXY)CARBONYLAMINO)-1-(TERT-BUTOXYCARBONYL)PYRROLIDINE-2-CARBOXYLICACID
• CAS号：1018332-24-5
• 分子式：C₂₅H₂₈N₂O₆
• 分子量：452.500
• 发布时间：2018-12-24 11:46:10
• 更新时间：2024-04-03 14:54:10

名称

• 中文名: N-boc-顺式-4-n-Fmoc-氨基-d-脯氨酸
• 英文名: (4R)-4-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}-1-{[(2-methyl-2- propanyl)oxy]carbonyl}-D-proline
• 英文别名: (2R-cis)-2-(Fluoromethyl)-4-hydroxy-1-pyrrolidinecarboxylic acid 1,1-dimethylethyl ester; (2R,4R)-N-Boc-2-(fluoromethyl)-4-hydroxypyrrolidine; (2R,4R)-1-(tert-butoxycarbonyl)-4-N-(9-fluorenylmethoxycarbonyl)aminoproline; (2R,4R)-1-(tert-butoxycarbonyl)-4-hydroxypiperidine-2-carboxylic acid; (4R)-4-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-D-proline; (2R,4R)-1-(tert-butoxycarbonyl)-4-hydroxy-2-(fluoromethyl)pyrrolidine; 1-Pyrrolidinecarboxylicacid,2-(fluoromethyl)-4-hydroxy-,1,1-dimethylethyl ester,(2R-cis)-(9CI); 1,2-Pyrrolidinedicarboxylic acid, 4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, 1-(1,1-dimethylethyl) ester, (2R,4R)-; (2R,4R)-tert-Butyl 2-(fluoromethyl)-4-hydroxypyrrolidine-1-carboxylate

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 650.2±55.0 °C at 760 mmHg
• 分子式: C₂₅H₂₈N₂O₆
• 分子量: 452.500
• 闪点: 347.0±31.5 °C
• 精确质量: 452.194733
• PSA: 108.66000
• LogP: 3.86
• 蒸汽压: 0.0±2.0 mmHg at 25°C
• 折射率: 1.627

合成路线

82911-69-1 132622-98-1 ~% 1018332-24-5

文献：Zanardi, Franca; Burreddu, Paola; Rassu, Gloria; Auzzas, Luciana; Battistini, Lucia; Curti, Claudio; Sartori, Andrea; Nicastro, Giuseppe; Menchi, Gloria; Cini, Nicoletta; Bottonocetti, Anna; Raspanti, Silvia; Casiraghi, Giovanni Journal of Medicinal Chemistry, 2008 , vol. 51, # 6 p. 1771 - 1782

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