1338225-97-0

• 常用中文名：Doravirine
• 常用英文名：Doravirine
• CAS号：1338225-97-0
• 分子式：C₁₇H₁₁ClF₃N₅O₃
• 分子量：425.749
• 相关类别： 信号通路 抗感染 HIV
• 发布时间：2019-01-14 12:10:53
• 更新时间：2024-01-03 16:29:02
• Doravirine是一种新型的非核苷的HIV- 1逆转录酶抑制剂.

名称

• 中文名: 3-氯-5-((1-((4-甲基-5-氧代-4,5-二氢-1H-1,2,4-噻唑-3-基)甲基)-2-氧代-4-(三氟甲基)-1,2-二氢吡啶-3-基)氧基)苯甲腈
• 英文名: 3-chloro-5-[1-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methyl]-2-oxo-4-(trifluoromethyl)pyridin-3-yl]oxybenzonitrile
• 英文别名: Doravirine; mk-1439; Benzonitrile, 3-chloro-5-[[1-[(4,5-dihydro-4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methyl]-1,2-dihydro-2-oxo-4-(trifluoromethyl)-3-pyridinyl]oxy]-; MK1439; 3-Chloro-5-({1-[(4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl]-2-oxo-4-(trifluoromethyl)-1,2-dihydro-3-pyridinyl}oxy)benzonitrile

物化性质

• 密度: 1.6±0.1 g/cm3
• 分子式: C₁₇H₁₁ClF₃N₅O₃
• 分子量: 425.749
• 精确质量: 425.050262
• PSA: 105.96000
• LogP: 3.01
• 折射率: 1.631
• 储存条件: 2-8℃

生物活性

• 描述: Doravirine是一种新型的非核苷的HIV- 1逆转录酶抑制剂.
• 相关类别:
  信号通路 >> 抗感染 >> HIV
  研究领域 >> 感染
• 参考文献:

  [1]. Feng M et al. Doravirine Suppresses Common Nonnucleoside Reverse Transcriptase Inhibitor-Associated Mutants at Clinically Relevant Concentrations. Antimicrob Agents Chemother. 2016 Mar 25;60(4):2241-7.

  [2]. Lai MT et al. In vitro characterization of MK-1439, a novel HIV-1 nonnucleoside reverse transcriptase inhibitor. Antimicrob Agents Chemother. 2014;58(3):1652-63.

  [3]. Anderson MS et al. Safety, tolerability and pharmacokinetics of doravirine, a novel HIV non-nucleoside reverse transcriptase inhibitor, after single and multiple doses in healthy subjects. Antivir Ther. 2015;20(4):397-405.