39800-16-3

• 常用中文名：培磷酰胺
• 常用英文名：4-Hydroperoxy cyclophosphamide
• CAS号：39800-16-3
• 分子式：C₇H₁₅Cl₂N₂O₄P
• 分子量：293.08500
• 相关类别： 信号通路 细胞凋亡 细胞凋亡
• 发布时间：2018-07-12 14:51:53
• 更新时间：2024-01-11 15:14:04
• 4-氢过氧基环磷酰胺是前药环磷酰胺的活性代谢产物。4-氢过氧环磷酰胺交联DNA,诱导T细胞凋亡,不依赖死亡受体激活,但通过产生活性氧(ROS)激活线粒体死亡途径。4-氢过氧环磷酰胺用于治疗淋巴瘤和自身免疫性疾病。

名称

• 中文名: 培磷酰胺
• 英文名: 4-hydroperoxycyclophosphamide
• 中文别名: 4-过氧羟基环磷酰胺
• 英文别名: PERFOSFAMIDE; ASTA 6496; 4-Hydroperoxycyclofosfamide; 4-Hydroperoxycyclophosphamide; 4-OOH Cyclophosphamide; N,N-bis(2-chloroethyl)-4-hydroperoxy-2-oxo-1,3,2λ⁵-oxazaphosphinan-2-amine; Perfosphamide; 4-Hydroperoxy-cyclophosphamid

物化性质

• 密度: 1.465g/cm3
• 沸点: 419.946ºC at 760 mmHg
• 熔点: 100-103ºC
• 分子式: C₇H₁₅Cl₂N₂O₄P
• 分子量: 293.08500
• 闪点: 207.776ºC
• 精确质量: 292.01500
• PSA: 80.84000
• LogP: 2.02850
• 折射率: 1.525
• 储存条件: -20°C，密闭，干燥

生物活性

• 描述: 4-氢过氧基环磷酰胺是前药环磷酰胺的活性代谢产物。4-氢过氧环磷酰胺交联DNA,诱导T细胞凋亡,不依赖死亡受体激活,但通过产生活性氧(ROS)激活线粒体死亡途径。4-氢过氧环磷酰胺用于治疗淋巴瘤和自身免疫性疾病。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  信号通路 >> 细胞周期/DNA损伤 >> DNA烷基化剂/交联剂

MSDS

Name: 4-Hydroxyperoxycyclophophamide Material Safety Data Sheet Synonym: None Known CAS: 39800-16-3 Section 1 - Chemical Product MSDS Name:4-Hydroxyperoxycyclophophamide Material Safety Data Sheet Synonym:None Known Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 39800-16-3 4-Hydroxyperoxycyclophophamide ca. 100 unlisted Hazard Symbols: None Listed. Risk Phrases: None Listed. Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW The toxicological properties of this material have not been fully investigated. Potential Health Effects Eye: May cause eye irritation. Skin: May cause skin irritation. May be harmful if absorbed through the skin. Ingestion: May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated. May be harmful if swallowed. Inhalation: May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated. May be harmful if inhaled. Chronic: No information found. Section 4 - FIRST AID MEASURES Eyes: In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical aid. Skin: In case of contact, flush skin with plenty of water. Remove contaminated clothing and shoes. Get medical aid if irritation develops and persists. Wash clothing before reuse. Ingestion: If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid. Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Treat symptomatically and supportively. Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or appropriate foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Avoid generating dusty conditions. Provide ventilation. Section 7 - HANDLING and STORAGE Handling: Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Storage: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 39800-16-3: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Solid Color: white Odor: Not available. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: Not available. Autoignition Temperature: Not available. Flash Point: Not available. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: Specific Gravity/Density: Molecular Formula: C7H15Cl2N2O4P Molecular Weight: 293.09 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable at room temperature in closed containers under normal storage and handling conditions. Conditions to Avoid: Dust generation. Incompatibilities with Other Materials: Strong oxidizing agents. Hazardous Decomposition Products: Hydrogen chloride, nitrogen oxides, carbon monoxide, oxides of phosphorus, carbon dioxide. Hazardous Polymerization: Has not been reported Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 39800-16-3: RP5900000 LD50/LC50: Not available. Carcinogenicity: 4-Hydroxyperoxycyclophophamide - Not listed by ACGIH, IARC, or NTP. Other: See actual entry in RTECS for complete information. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Products which are considered hazardous for supply are classified as Special Waste and the disposal of such chemicals is covered by regulations which may vary according to location. Contact a specialist disposal company or the local waste regulator for advice. Empty containers must be decontaminated before returning for recycling. Section 14 - TRANSPORT INFORMATION IATA Not regulated as a hazardous material. IMO Not regulated as a hazardous material. RID/ADR Not regulated as a hazardous material. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: Not available. Risk Phrases: Safety Phrases: S 24/25 Avoid contact with skin and eyes. WGK (Water Danger/Protection) CAS# 39800-16-3: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 39800-16-3 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 39800-16-3 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : RP5900000 CHEMICAL NAME : 2H-1,3,2-Oxazophosphorine, 2-(bis(2-chloroethyl)amino)-4-hydroperoxytetrahydro-, 2-oxide CAS REGISTRY NUMBER : 39800-16-3 LAST UPDATED : 199612 DATA ITEMS CITED : 12 MOLECULAR FORMULA : C7-H15-Cl2-N2-O4-P MOLECULAR WEIGHT : 293.11 WISWESSER LINE NOTATION : T6MPOTJ BN2G2G FOQ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 76040 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value MUTATION DATA TYPE OF TEST : DNA damage TEST SYSTEM : Rodent - hamster Lung DOSE/DURATION : 5 mg/L REFERENCE : BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 35,1163,1986