86408-72-2

• 常用中文名：伊卡倍特钠
• 常用英文名：Ecabet sodium
• CAS号：86408-72-2
• 分子式：C₂₀H₂₇NaO₅S
• 分子量：402.480
• 相关类别： 信号通路 抗感染 细菌
• 发布时间：2018-02-14 08:00:00
• 更新时间：2024-01-02 11:35:39
• Ecabet sodium (TA-2711) 可通过抑制 ROS 的产生应用于某些临床胃肠道疾病。Ecabet sodium 可以促进幽门螺杆菌的根除。Ecabet sodium 减少细胞凋亡 (apoptosis)。

名称

• 中文名: 伊卡倍特钠
• 英文名: Ecabet sodium
• 中文别名: 依卡倍特钠
• 英文别名: 12-sulfodehydroabietic acid 12-sodium salt pentahydrate; Ecabetsodiumsalt; Sodium 18-hydroxy-18-oxoabieta-8(14),9(11),12-triene-12-sulfonate; 1-Phenanthrenecarboxylic acid, 1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-6-sulfo-, sodium salt, (1R,4aS,10aR)- (1:1); 1-Phenanthrenecarboxylic acid,1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-6-sulfo-,monosodium salt,(1R,4aS,10aR); Gastrom; 12-Sulfodehydroabietic acid monosodium salt; ta-2711

物化性质

• 密度: 1.241 g/cm3
• 分子式: C₂₀H₂₇NaO₅S
• 分子量: 402.480
• 精确质量: 402.147675
• PSA: 102.88000
• LogP: 4.88980
• 折射率: 1.562
• 储存条件: 室温，干燥

生物活性

• 描述: Ecabet sodium (TA-2711) 可通过抑制 ROS 的产生应用于某些临床胃肠道疾病。Ecabet sodium 可以促进幽门螺杆菌的根除。Ecabet sodium 减少细胞凋亡 (apoptosis)。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 靶点:

  ROS production; Bacterial[1]; Apoptosis[2]

• 参考文献:

  [1]. Wang Y, et al. Efficacy and safety of ecabet sodium as an adjuvant therapy for Helicobacter pylori eradication: a systematic review and meta-analysis. Helicobacter. 2014 Oct;19(5):372-81.

  [2]. Rah YC, et al. Ecabet sodium alleviates neomycin-induced hair cell damage. Free Radic Biol Med. 2015 Dec;89:1176-83.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : SF7312000 CHEMICAL NAME : 1-Phenanthrenecarboxylic acid, 1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-meth ylethyl)- 6-sulfo-, (1R-(1-alpha,4a-beta,10a-alpha))-, monosodium salt CAS REGISTRY NUMBER : 86408-72-2 LAST UPDATED : 199603 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C20-H28-O5-S.Na MOLECULAR WEIGHT : 403.53 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4529602 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 11 gm/kg SEX/DURATION : female 7-17 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 25,941,1991

安全

• 危害码 (欧洲): Xi

合成路线

86408-71-1 ~88% 86408-72-2

文献：Wada; Kodato; Kawamori; Morikawa; Nakai; Takeda; Saito; Onoda; Tamaki Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 4 p. 1472 - 1487

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