83-98-7

• 常用中文名：邻甲苯海明
• 常用英文名：orphenadrine
• CAS号：83-98-7
• 分子式：C₁₈H₂₃NO
• 分子量：269.38100
• 相关类别： 原料药 神经系统用药 抗震颤麻痹药
• 发布时间：2018-06-12 18:02:17
• 更新时间：2024-01-11 15:25:58

名称

• 中文名: 邻甲苯海明
• 英文名: orphenadrine
• 中文别名: 2-(苯基邻甲苯甲氧基)乙基二甲基胺; 奥芬那君
• 英文别名: N,N-dimethyl-2-[(2-methylphenyl)-phenylmethoxy]ethanamine; <2-Dimethylamino-aethyl>-<2-methyl-benzhydryl>-aether; Orphenedrine; Disipal; Mephenamine; Brocadisipal; Dimethyl-[2-(2-methyl-benzhydryloxy)-aethyl]-amin; 2-Methyldiphenhydramine; Orphenadrin; Biorphen; Orphenadine; o-Methyldiphenhydramine; dimethyl-[2-(2-methyl-benzhydryloxy)-ethyl]-amine

物化性质

• 密度: 1.0278 (rough estimate)
• 沸点: 195ºC at 12 ATM
• 熔点: 25°C
• 分子式: C₁₈H₂₃NO
• 分子量: 269.38100
• 精确质量: 269.17800
• PSA: 12.47000
• LogP: 3.66260
• 折射率: 1.5740 (estimate)

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : KR6120000 CHEMICAL NAME : Ethylamine, N,N-dimethyl-2-((o-methyl-alpha-phenylbenzyl)oxy)- CAS REGISTRY NUMBER : 83-98-7 BEILSTEIN REFERENCE NO. : 1885151 LAST UPDATED : 199612 DATA ITEMS CITED : 8 MOLECULAR FORMULA : C18-H23-N-O MOLECULAR WEIGHT : 269.42 WISWESSER LINE NOTATION : 1N1&2OYR&R B1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human DOSE/DURATION : 14 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - coma Cardiac - arrhythmias (including changes in conduction) REFERENCE : APTSAI Acta Pharmacologica et Toxicologica, Supplementun. (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) No.1- 1947- Volume(issue)/page/year: 41(2),137,1977 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human DOSE/DURATION : 7143 mg/kg TOXIC EFFECTS : Behavioral - coma Cardiac - pulse rate increase, without fall in BP Vascular - BP elevation not characterized in autonomic section REFERENCE : ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978- Volume(issue)/page/year: 4,425,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 125 mg/kg TOXIC EFFECTS : Behavioral - changes in motor activity (specific assay) REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 138,62,1962 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 80 mg/kg TOXIC EFFECTS : Behavioral - changes in motor activity (specific assay) REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 138,62,1962 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 150 mg/kg TOXIC EFFECTS : Behavioral - changes in motor activity (specific assay) REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 138,62,1962 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 33 mg/kg TOXIC EFFECTS : Behavioral - changes in motor activity (specific assay) REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 138,62,1962 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84469 No. of Facilities: 14 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1092 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84469 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 103 (estimated) No. of Female Employees: 52 (estimated)

安全

• 危险品运输编码: UN 1851
• 包装等级: III
• 危险类别: 6.1(b)
• 海关编码: 2922199090

合成路线

29215-00-7 ~90% 83-98-7

文献：Gowda, Narendra B.; Rao, Gopal Krishna; Ramakrishna, Ramesha A. Tetrahedron Letters, 2010 , vol. 51, # 43 p. 5690 - 5693

108-01-0 41870-52-4 ~% 83-98-7

文献：J. Med. Chem., , vol. 2, p. 57 - 77

108-01-0 ~% 83-98-7

文献：Arzneimittelforschung, , vol. 5, p. 72

上下游产品

上游产品  3
29215-00-7 108-01-0 41870-52-4
下游产品  1
29215-00-7

海关

海关编码	2922199090
中文概述	2922199090. 其他氨基醇及其醚，酯和它们的盐（但含一种以上含氧基的除外）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
Summary	2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%