3223-07-2

• 常用中文名：盐酸美法仑
• 常用英文名：Melphalan hydrochloride
• CAS号：3223-07-2
• 分子式：C₁₃H₁₉Cl₃N₂O₂
• 分子量：341.661
• 相关类别： 生物化工 氨基酸及其衍生物 苯丙氨酸类衍生物
• 发布时间：2018-03-22 08:00:00
• 更新时间：2024-01-01 18:09:33

名称

• 中文名: 左旋苯丙氨酸氮芥盐酸盐
• 英文名: Melphalan hydrochloride
• 中文别名: 盐酸美法仑; 盐酸美法仑; (S)-3-[4-[双(2-氯乙基)氨基]苯基]丙氨酸盐酸盐
• 英文别名: DL-Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-, hydrochloride; DL-Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-, monohydrochloride; L-phenylalanine, 4-[bis(2-chloroethyl)amino]-, monohydrochloride; 4-[Bis(2-chloroethyl)amino]-L-phenylalanine hydrochloride (1:1); acide (2S)-2-amino-3-{4-[bis(2-chloroéthyl)amino]phényl}propanoïque chlorhydrate; DL-Phenylalanine, 4-(bis(2-chloroethyl)amino)-, monohydrochloride (9CI); L-Phenylalanine, 4-(bis(2-chloroethyl)amino)-, monohydrochloride (9CI); (2S)-2-amino-3-{4-[bis(2-chloroethyl)amino]phenyl}propanoic acid hydrochloride; 4-(Bis(2-chloroethyl)amino)-L-phenylalanine Monohydrochloride; 3-(p-(Bis(β-chloroethyl)amino)phenyl)-D,L-alanine hydrochloride; 4-(Bis(2-chloroethyl)amino)-DL-phenylalanine hydrochloride; Melphalan Hydrochloride,Phenylalanine, 4-[bis(2-chloroethyl)amino]-, hydrochloride (1:1); (2S)-2-Amino-3-{4-[bis(2-chlorethyl)amino]phenyl}propansäurehydrochlorid; 3-[p-[Bis(β-chloroethyl)amino]phenyl]-D,L-alanine, hydrochloride; 4-[bis(2-chloroethyl)amino]-L-phenylalanine hydrochloride; L-Phenylalanine, 4-[bis(2-chloroethyl)amino]-, hydrochloride (1:1); 3-(p-(Bis(2-chloroethyl)amino)phenyl)-DL-alanine hydrochloride; DL-Alanine, 3-(p-[bis(2-chloroethyl)amino]phenyl)-, hydrochloride; L-Alanine, 3-(p-[bis(2-chloroethyl)amino]phenyl)-, hydrochloride; 3-(p-(Bis(2-chloroethyl)amino)phenyl)-L-alanine Hydrochloride

物化性质

• 沸点: 473.1ºC at 760mmHg
• 分子式: C₁₃H₁₉Cl₃N₂O₂
• 分子量: 341.661
• 闪点: 239.9ºC
• 精确质量: 340.051208
• PSA: 66.56000
• LogP: 3.42730
• 外观性状: 固体
• 储存条件: 库房通风低温干燥,与食品原料分开存放

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : AY4025000 CHEMICAL NAME : Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-, monohydrochloride, L- CAS REGISTRY NUMBER : 3223-07-2 LAST UPDATED : 199706 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C13-H18-Cl2-N2-O2.Cl-H MOLECULAR WEIGHT : 341.69 WISWESSER LINE NOTATION : QVYZ1R DN2G2G &GH -L HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human DOSE/DURATION : 1200 ug/kg/5D-I TOXIC EFFECTS : Gastrointestinal - nausea or vomiting REFERENCE : CCROBU Cancer Chemotherapy Reports, Part 1. (Washington, DC) V.52(6)-59, 1968-75. For publisher information, see CTRRDO. Volume(issue)/page/year: 57,369,1973 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 430 ug/kg TOXIC EFFECTS : Blood - leukopenia Blood - thrombocytopenia Blood - other changes REFERENCE : CCSUBJ Cancer Chemotherapy Reports, Part 2. (Washington, DC) V.1-5, 1964-75. For publisher information, see CTRRDO. Volume(issue)/page/year: 2,201,1965 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Primate - monkey DOSE/DURATION : 430 ug/kg TOXIC EFFECTS : Blood - leukopenia Blood - agranulocytosis Blood - other changes REFERENCE : CCSUBJ Cancer Chemotherapy Reports, Part 2. (Washington, DC) V.1-5, 1964-75. For publisher information, see CTRRDO. Volume(issue)/page/year: 2,201,1965 ** TUMORIGENIC DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1300 ug/kg/4W TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors REFERENCE : JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 36,915,1966

安全

• 危害码 (欧洲): Xn
• 海关编码: 2922499990

海关

海关编码	2922499990
中文概述	2922499990 其他氨基酸及其酯及它们的盐（含有一种以上含氧基的除外）. 增值税率:17.0% 退税率:9.0% 监管条件:AB(入境货物通关单,出境货物通关单) 最惠国关税:6.5% 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
监管条件	A.入境货物通关单 B.出境货物通关单
检验检疫	P.进境动植物、动植物产品检疫 Q.出境动植物、动植物产品检疫 R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验
Summary	HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%