25496-72-4

• 常用中文名：单油酸甘油酯
• 常用英文名：Glyceryl monooleate
• CAS号：25496-72-4
• 分子式：C₂₁H₄₀O₄
• 分子量：356.540
• 相关类别： 研究领域 其他
• 发布时间：2018-07-12 18:32:55
• 更新时间：2024-01-02 10:57:00
• 单酸甘油酯是一种无毒、可生物降解、生物相容的亲脂性甘油脂肪酸酯。甘油单油酸酯具有溶血特性。甘油单油酸酯与胆盐一起用作乳化剂和吸收促进剂。单酸甘油酯可用于药物传递系统和体外siRNA传递[1][2]。

名称

• 中文名: 甘油单油酸酯
• 英文名: Glycerol mono-oleate
• 中文别名: 单油酸甘油酯
• 英文别名: Glyceryl cis-9-octadecenoate; 9-Octadecenoic acid, 2-hydroxy-1-(hydroxymethyl)ethyl ester, (9Z)-; Oleic monoglyceride; 9-Octadecenoic acid (9Z)-, monoester with 1,2,3-propanetriol; 1-monooleoyl-rac-glycerol; 1-(cis-9-Octadecenoyl)-rac-glycerol; 1-Monooleoylglycerol; rac-Glycerol 1-monooleate; Glycerin 1-monooleate; glycerol monooleate; rac 1-Oleoyl Glycerol; 4,5-Dihydroxypentyl (7Z)-7-hexadecenoate; Glycerin monooleate; Oleic acid glycerol monoester; 1,3-Dihydroxypropan-2-yl (9Z)-octadec-9-enoate; Glycerine monooleate; 1-O-Oleyl-rac-glycerol; 1-oleoyl glycerol; 1-OLEOYLGLYCEROL; OLEOYL GLYCEROL; GLYCEROL OLEATE; 9-Octadecenoic acid, 2,3-dihydroxypropyl ester, (9Z)-; 1,3-Dihydroxy-2-propanyl (9Z)-9-octadecenoate; MFCD00042735; 2,3-Dihydroxypropyl (9Z)-9-octadecenoate; 2,3-Dihydroxypropyl oleate; GLYCEROL MONO-OLEATE; MONO OLEIN; Glycerine oleate; 1-GLYCERYL OLEATE; Glycerol Alpha-Monooleate; GLYCERYL MONOOLEATE; 2,3-Dihydroxypropyl (9Z)-octadec-9-enoate; a-Monoolein; DL-ALPHA-MONOOLEIN; Monoolein 9 C18:1; Danisco MO 90; GLYCEROL MONO OLEATE; Monoolein (VAN); 2-hydroxy-1-(hydroxymethyl)ethyl (9Z)-octadec-9-enoate; 1-Oleoyl-rac-glycerol; 2-Oleoylglycerol; Glyceryl Monooleate (VAN); RAC.-1-OLEOYL-GLYCEROL BIOCHEMICA; (9Z)-9-Octadecenoic Acid 2,3-Dihydroxypropyl Ester; dl-α-Monoolein; Glycerol α-monooleate; UNII:D3AEF6S35P; α-Monoolein; rac-1-Monooleoylglycerol; 7-Hexadecenoic acid, 4,5-dihydroxypentyl ester, (7Z)-; 9-Octadecenoic acid (9Z)-, ester with 1,2,3-propanetriol; Monoolein; 1-Mono(cis-9-octacenoyl)glycerol; EINECS 247-038-6; Aldo HMO

物化性质

• 密度: 1.0±0.1 g/cm3
• 沸点: 483.3±35.0 °C at 760 mmHg
• 熔点: 36 - 40ºC
• 分子式: C₂₁H₄₀O₄
• 分子量: 356.540
• 闪点: 155.4±19.4 °C
• 精确质量: 356.292664
• PSA: 66.76000
• LogP: 6.71
• 外观性状: 白色蜡质糊
• 蒸汽压: 0.0±2.8 mmHg at 25°C
• 折射率: 1.479
• 储存条件: −20°C
• 水溶解性: chloroform: 50 mg/mL, clear, colorless

生物活性

• 描述: 单酸甘油酯是一种无毒、可生物降解、生物相容的亲脂性甘油脂肪酸酯。甘油单油酸酯具有溶血特性。甘油单油酸酯与胆盐一起用作乳化剂和吸收促进剂。单酸甘油酯可用于药物传递系统和体外siRNA传递[1][2]。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Milak S, et al. Glycerol monooleate liquid crystalline phases used in drug delivery systems. Int J Pharm. 2015 Jan 30;478(2):569-87.

  [2]. Zhen G, et al. Glycerol monooleate-based nanocarriers for siRNA delivery in vitro. Mol Pharm. 2012 Sep 4;9(9):2450-7.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : RK1300000 CHEMICAL NAME : Olein, mono- CAS REGISTRY NUMBER : 25496-72-4 LAST UPDATED : 199701 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C21-H40-O4 MOLECULAR WEIGHT : 356.61 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rabbit REFERENCE : JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 5(5),391,1986 TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : Administration into the eye SPECIES OBSERVED : Rodent - rabbit REFERENCE : JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 5(5),391,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83110 No. of Facilities: 4016 (estimated) No. of Industries: 41 No. of Occupations: 51 No. of Employees: 74220 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83110 No. of Facilities: 9941 (estimated) No. of Industries: 81 No. of Occupations: 78 No. of Employees: 159120 (estimated) No. of Female Employees: 39063 (estimated)

安全

• 危险品运输编码: NONH for all modes of transport
• WGK德国: 1