16024-60-5

• 常用中文名：m-PEG3-CH2COOH
• 常用英文名：m-PEG3-CH2COOH
• CAS号：16024-60-5
• 分子式：C₉H₁₈O₆
• 分子量：222.23600
• 相关类别： 信号通路 蛋白裂解靶向嵌合体 PROTAC Linker
• 发布时间：2016-12-02 06:01:51
• 更新时间：2024-01-09 12:43:56
• m-PEG3-CH2COOH 是一种基于 PEG 的 PROTAC linker,用于 PROTAC 合成。

名称

• 中文名: 3,6,9,12-四氧杂十三烷酸
• 英文名: 2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]acetic acid
• 英文别名: (monomethoxy)triethylene glycol acetic acid; 2-(2-(2-methoxyethoxy)-ethoxy)-ethoxy-acetic acid; 3,6,9,12-tetraoxatridecanoic acid; CH3O-TEG acetic acid; 2,5,8,11-Tetraoxatridecan-13-oic acid

物化性质

• 分子式: C₉H₁₈O₆
• 分子量: 222.23600
• 精确质量: 222.11000
• PSA: 74.22000
• 储存条件: 室温，干燥，密封

生物活性

• 描述: m-PEG3-CH2COOH 是一种基于 PEG 的 PROTAC linker,用于 PROTAC 合成。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 蛋白裂解靶向嵌合体 >> PROTAC Linker
• 靶点:

  PEGs

• 体外研究: PROTACs包含两种不同的配体,它们通过连接体连接；一种是E3泛素连接酶的配体,另一种是靶蛋白的配体。PROTACs利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白。
• 参考文献:

  [1]. Chen X, et al. Histidine-Specific Peptide Modification via Visible-Light-Promoted C-H Alkylation. J Am Chem Soc. 2019 Nov 13;141(45):18230-18237.

安全

• 危害码 (欧洲): Xi

合成路线

186429-53-8 ~% 16024-60-5

文献：ISIS PHARMACEUTICALS, INC.; BUCHARDT, Dorte; NIELSEN, Peter Eigil; EGHOLM, Michael Patent: EP804456 B1, 2002 ;

112-35-6 79-11-8 ~82% 16024-60-5

文献：Zech, Oliver; Kellermeier, Matthias; Thomaier, Stefan; Maurer, Eva; Klein, Regina; Schreiner, Christian; Kunz, Werner Chemistry - A European Journal, 2009 , vol. 15, # 6 p. 1341 - 1345

1197192-17-8 ~30% 16024-60-5

文献：Rerat, Vincent; Dive, Georges; Cordi, Alex A.; Tucker, Gordon C.; Bareille, Reine; Amedee, Joelle; Bordenave, Laurence; Marchand-Brynaert, Jacqueline Journal of Medicinal Chemistry, 2009 , vol. 52, # 22 p. 7029 - 7043

331992-12-2 ~96% 16024-60-5

文献：Simeone, Luca; Mangiapia, Gaetano; Vitiello, Giuseppe; Irace, Carlo; Colonna, Alfredo; Ortona, Ornella; Montesarchio, Daniela; Paduano, Luigi Bioconjugate Chemistry, 2012 , vol. 23, # 4 p. 758 - 770 Title/Abstract Full Text View citing articles Show Details Simeone, Luca; Mangiapia, Gaetano; Irace, Carlo; Di Pascale, Antonio; Colonna, Alfredo; Ortona, Ornella; De Napoli, Lorenzo; Montesarchio, Daniela; Paduano, Luigi Molecular BioSystems, 2011 , vol. 7, # 11 p. 3075 - 3086

73159-12-3 ~96% 16024-60-5

文献：Haines, Alan H.; Karntiang, Pipat Carbohydrate Research, 1980 , vol. 78, p. 205 - 211

23783-42-8 ~% 16024-60-5

文献：Heidkamp, Katharina; Aytemir, Memet; Vorlop, Klaus-Dieter; Pruesse, Ulf Catalysis Science and Technology, 2013 , vol. 3, # 11 p. 2984 - 2992

112-35-6 ~% 16024-60-5

文献：Simeone, Luca; Mangiapia, Gaetano; Vitiello, Giuseppe; Irace, Carlo; Colonna, Alfredo; Ortona, Ornella; Montesarchio, Daniela; Paduano, Luigi Bioconjugate Chemistry, 2012 , vol. 23, # 4 p. 758 - 770 Title/Abstract Full Text View citing articles Show Details Simeone, Luca; Mangiapia, Gaetano; Irace, Carlo; Di Pascale, Antonio; Colonna, Alfredo; Ortona, Ornella; De Napoli, Lorenzo; Montesarchio, Daniela; Paduano, Luigi Molecular BioSystems, 2011 , vol. 7, # 11 p. 3075 - 3086

112-35-6 3926-62-3 ~% 16024-60-5

文献：Hu, Wei; Yan, Qifan; Zhao, Dahui Chemistry - A European Journal, 2011 , vol. 17, # 25 p. 7087 - 7094

112-35-6 79-08-3 ~% 16024-60-5

文献：Tuchscherer; Schaarschmidt; Schulze; Hietschold; Lang Dalton Transactions, 2012 , vol. 41, # 9 p. 2738 - 2746