3401-80-7

• 常用中文名：3,6-二氯-2-羟基苯甲酸
• 常用英文名：3,6-Dichlorosalicylic acid
• CAS号：3401-80-7
• 分子式：C₇H₄Cl₂O₃
• 分子量：207.01100
• 相关类别： 化学农药原药 除草剂 除草剂中间体
• 发布时间：2018-09-15 16:44:24
• 更新时间：2024-01-02 10:31:59
• 【用途一】
  3，6-二氯-2-羟基苯甲酸是除草剂麦草畏的中间体。

名称

• 中文名: 3,6-二氯水杨酸
• 英文名: 3,6-dichloro-2-hydroxybenzoic acid
• 中文别名: 3,6-二氯-2-羟基苯甲酸
• 英文别名: 3,6-DICHLOROSALICYLIC ACID; 2-Hydroxy-3,6-dichlorobenzoic acid; 3,6-Dichlor-2-hydroxy-benzoesaeure; 2-hydroxy-3,5-dichlorobenzoic acid; Benzoic acid,3,6-dichloro-2-hydroxy; EINECS 222-275-8; MFCD00155381; 3,6-Dichloro-2-hydroxy-benzoic acid; Salicylic acid,3,6-dichloro; 2-Oxy-3,6-dichlorobenzoic acid

物化性质

• 密度: 1.665 g/cm3
• 沸点: 306.7ºC at 760 mmHg
• 分子式: C₇H₄Cl₂O₃
• 分子量: 207.01100
• 闪点: 139.3ºC
• 精确质量: 205.95400
• PSA: 57.53000
• LogP: 2.39720
• 折射率: 1.641
• 储存条件: 室温，干燥

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : VO2500000 CHEMICAL NAME : Salicylic acid, 3,6-dichloro- CAS REGISTRY NUMBER : 3401-80-7 BEILSTEIN REFERENCE NO. : 2938787 LAST UPDATED : 199701 DATA ITEMS CITED : 7 MOLECULAR FORMULA : C7-H4-Cl2-O3 MOLECULAR WEIGHT : 207.01 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1560 mg/kg TOXIC EFFECTS : Brain and Coverings - recordings from specific areas of CNS REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 43(10),95,1978 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 660 mg/kg TOXIC EFFECTS : Brain and Coverings - recordings from specific areas of CNS REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 43(10),95,1978 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 50 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB85-143766 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 1800 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 25(9),55,1981 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 546 mg/kg/26W-I TOXIC EFFECTS : Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - catalases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 43(10),95,1978 TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 5230 ug/m3/26W-I TOXIC EFFECTS : Lungs, Thorax, or Respiration - emphysema REFERENCE : GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 25(9),55,1981

安全

• 海关编码: 2918290000

合成路线

60-29-7 ~% 3401-80-7

文献：US4161611 A1, ;

583-78-8 68938-81-8 ~% 3401-80-7

文献：US4232172 A1, ;

1918-00-9 ~% 50-00-0 3401-80-7

文献：ACS Chemical Biology, , vol. 8, # 8 p. 1687 - 1691

上下游产品

上游产品  4
60-29-7 583-78-8 68938-81-8 1918-00-9
下游产品  1
1918-00-9

制备

【方法一】
其制备方法是将2，5-二氯苯酚与液体烧碱制得酚钠盐溶液，真空干燥，然后将釜温冷至100℃，慢慢通入干燥的二氧化碳，当釜内压力达到588～686kPa时停止通入二氧化碳，生成碳酸苯酚酯，在130～140℃发生分子重排反应得3，6-二氯-2-羟基苯甲酸钠，然后加水溶解，过滤，再加酸酸化得到产品。

海关

海关编码	2918290000
中文概述	2918290000 其他含酚基但不含其他含氧基羧酸及其酸酐、酰卤化物、过氧化物和过氧酸及它们的衍生物。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%
申报要素	品名, 成分含量, 用途
监管条件	A.入境货物通关单 B.出境货物通关单
检验检疫	R.进口食品卫生监督检验 S.出口食品卫生监督检验
Summary	HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%