107-02-8

• 常用中文名：丙烯醛
• 常用英文名：acrolein
• CAS号：107-02-8
• 分子式：C₃H₄O
• 分子量：56.063
• 相关类别： 有机原料 醛类化合物
• 发布时间：2018-02-13 08:00:00
• 更新时间：2024-01-03 12:19:02
• 【用途一】
  用作色谱分析标准物质，也用于有机合成
  【用途二】
  主要用于制蛋氨酸和其他丙烯醛衍生物
  【用途三】
  国外用作油田注水杀菌剂，以抑制水中细菌的生长，防止细菌在地层造成腐蚀及堵塞。
  【用途四】
  国外用作油田注入水的杀菌剂，以抑制注入水中的细菌生长，防止细菌在地层造成腐蚀及堵塞等问题。丙烯醛是重要的有机合成中间体，可用于制造蛋氨酸（饲料添加剂）。丙烯醛经还原生成的烯丙醇用作生产甘油的原料；经氧化生成丙烯酸，可进一步制丙烯酸酯用于丙烯酸酯涂料。丙烯醛的二聚体可用于制二醛类化合物，广泛用作造纸、鞣革和纺织助剂。丙烯醛是戊二醛、1,2,6-己三醇及交联剂等的原料，还用于胶体锇、钌、铑的制造。丙烯醛与溴作用可得到2,3-二溴丙醛。2.3-二溴丙醛是医药中间体，用来生产抗肿瘤药甲胺蝶呤等。
  【用途五】
  107-02-8（丙烯醛）可用于制造蛋氨酸(饲料添加剂)；107-02-8（丙烯醛）与溴作用可得到2,3-二溴丙醛，用来生产抗肿瘤药甲胺蝶呤。107-02-8的二聚体可用于制二醛类化合物，广泛用于造纸、鞣革和纺织助剂

名称

• 中文名: 丙烯醛
• 英文名: acrolein
• 中文别名: 4-羟基肉桂醛; 2-溴-4-氟-5-甲基苯胺
• 英文别名: EINECS 203-453-4; 2-Propene-1-one; N-Acetylphenylalanylglycine 4-nitroanilide; Acrolein (stabilized with hydroquinone); VH1U1; Prop-2-enal; Nacphe-gly-4-NA; acrolein; 2-Propen-1-one; acraldehyde; Aldehyde, Allyl; N-Acetyl-L-phenylalanylglycin-p-nitroanilid; propylene aldehyde; 1-Propen-3-one; 2-Propenal; Prop-2-en-1-al; Ac-Phe-Gly-(p-Nitroanilid); Glycinamide,N-acetyl-L-phenylalanyl-N-(4-nitrophenyl); MFCD00006998; Propenaldehyde; Acrylaldehyde; Propenal

物化性质

• 密度: 0.8±0.1 g/cm3
• 沸点: 52.8±9.0 °C at 760 mmHg
• 熔点: −87 °C(lit.)
• 分子式: C₃H₄O
• 分子量: 56.063
• 闪点: -18.9±0.0 °C
• 精确质量: 56.026215
• PSA: 17.07000
• LogP: -0.01
• 外观性状: 无色至略黄色液体
• 蒸汽密度: 1.94 (vs air)
• 蒸汽压: 261.3±0.1 mmHg at 25°C
• 折射率: 1.368
• 储存条件:

  1.储存注意事项 储存于阴凉、通风良好的专用库房内，实行“双人收发、双人保管”制度。远离火种、热源。库温不宜超过29℃。包装要求密封，不可与空气接触。应与氧化剂、还原剂、酸类、碱类、食用化学品分开存放，切忌混储。不宜大量储存或久存。采用防爆型照明、通风设施。禁止使用易产生火花的机械设备和工具。储区应备有泄漏应急处理设备和合适的收容材料。

  2.丙烯醛在光、热或微量污物的影响下，会迅速聚合，同时释放出大量热量而有发生爆炸的危险。在无机酸、碱或胺类的作用下，也会高度发热。如果与无机酸、碱接触，宜加入缓冲溶液（冰醋酸84%，照相级对苯二酚8%，无水碳酸钠8%）加以控制。贮运所用设备及管道阀门必须十分洁净，并用惰性气体扫洗。按危险品规定贮运。

• 稳定性:

  1.化学性质：丙烯醛兼含有双键和醛基，具有两种官能团的典型反应。丙烯醛的双键可以与醇、硫醇、水、胺、有机酸和无机酸，活泼亚甲基化合物在酸或碱催化下发生加成反应。丙烯醛的醛基可以与醇或多羟基物质在温和的酸性条件下发生缩醛反应。双键与醛基可以相互影响，使丙烯醛表现出特有的性质。

  2.本品为刺激性强的极毒液体，强烈地刺激眼和呼吸道黏膜，造成眼结膜炎、喉炎、支气管炎，更高浓度的蒸气能引起肺炎、肺出血、肺水肿和呼吸困难。误服丙烯醛会引起严重肠胃病及肺出血等。亦可经皮肤吸收而中毒。小鼠皮下注射LD5030mg/kg,工作场所空气中最高容许浓度0.25mg/m3。操作人员应戴防护口罩。

  3.丙烯醛是一种具有高度刺激性，极毒的液体，在空气中最高容许浓度为0.3mg/m3。直接与其接触会损伤眼睛和呼吸道，是一种很强的催泪毒气。吸入人体会引起肠胃不适、肺充血和水肿。

  4.稳定性 稳定

  5.禁配物 强氧化剂、强还原剂、氧、酸类、碱类、氨、胺类、二氧化硫、硫脲、金属盐类等。

  6.避免接触的条件 受热、光照、接触空气

  7.聚合危害 聚合

• 水溶解性: Soluble. 21.25 g/100 mL
• 分子结构:

  1、摩尔折射率：15.85

  2、摩尔体积（cm³/mol）：70.4

  3、等张比容（90.2K）：149.3

  4、表面张力（dyne/cm）：20.1

  5、介电常数：

  6、偶极距（10^-24cm³）：

  7、极化率：6.28

• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:0

  3.氢键受体数量:1

  4.可旋转化学键数量:1

  5.互变异构体数量:无

  6.拓扑分子极性表面积17.1

  7.重原子数量:4

  8.表面电荷:0

  9.复杂度:30.3

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

• 更多:

  1.性状：无色或淡黄色液体，有恶臭。

  2.pH值：6（10%水溶液）

  3.熔点（℃）：-87.7

  4.沸点（℃）：52.5

  5.相对密度（水=1）：0.84

  6.相对蒸气密度（空气=1）：1.94

  7.饱和蒸气压（kPa）：29.33（20℃）

  8.燃烧热（kJ/mol）：-1625.74

  9.临界压力（MPa）：5.06

  10.辛醇/水分配系数：-0.01~0.9

  11.闪点（℃）：-26（CC）

  12.引燃温度（℃）：234

  13.爆炸上限（%）：31.0

  14.爆炸下限（%）：2.8

  15.溶解性：溶于水，易溶于乙醇、丙酮等多数有机溶剂。

  16.黏度（mPa·s,20ºC）：0.35

  17.常温折射率（n²⁵）：1.3974^24.5

  18.气相标准熵(J·mol^-1·K^-1) ：281.7

  19.液相标准燃烧热(焓)(kJ·mol^-1)：-1638.68

  20.液相标准声称热(焓)( kJ·mol^-1)：-113.51

  21.液相标准热熔(J·mol^-1·K^-1)：121.1

MSDS

国标编号: 31024 ＣＡＳ: 107-02-8 中文名称: 丙烯醛 英文名称: acrolein；allylaldehyde 别 名: 烯丙醛 分子式: C3H4O；CH2CHCHO 分子量: 56.06 熔 点: -87.7℃ 沸点：52.5℃ 密 度: 相对密度(水=1)0.84； 蒸汽压: -26℃ 溶解性: 溶于水，易溶于醇、丙酮等多数有机溶剂 稳定性: 不稳定 外观与性状: 无色或淡黄色液体，有恶臭 危险标记: 7(低闪点易燃液体) 用 途: 为合成树脂工业的重要原料之一，也大量用于有机合成与药物合成 2.对环境的影响: 一、健康危害 侵入途径：吸入、食入、经皮吸收。 健康危害：本品有强烈刺激性。吸入蒸气损害呼吸道，出现咽喉炎、胸部压迫感、支气管炎；大量吸入可致肺炎、肺水肿，尚可出现休克、肾炎及心力衰竭。可致死。液体及蒸气损害眼睛；皮肤接触可致灼伤。口服引起口腔及胃刺激或灼伤。 二、毒理学资料及环境行为 毒性：属高毒类。 急性毒性：LD 5046mg/kg(大鼠经口)；562mg/kg(兔经皮)；LC 50300mg/m ^3，1/2小时(大鼠吸入)人吸入2.3mg/m ^3×5分钟，不能忍受；人吸入153ppm×10分钟，最小致死浓度；人经口5mg/kg最小致死剂量。 刺激性：家兔经眼：1mg，重度刺激。家兔经皮：5mg，重度刺激。 亚急性和慢性毒性：大鼠持续接触本品浓度低至4.8mg/m ^3，40小时后，其肝脏的碱性磷酸酶活性升高。 致突变性：微生物致突变性：鼠伤寒沙门氏菌20nL/皿。微粒体致突变：鼠伤寒沙门氏菌50µl/皿。 生殖毒性：大鼠静脉最低中毒剂量(TDL 0)：6mg/kg(孕后用药9天)，胚泡植入后死亡率升高。 致癌性：IARC致癌性评论：动物为不肯定性反应。 危险特性：其蒸气与空气可形成爆炸性混合物，遇明火、高热极易燃烧爆炸。受热分解释出高毒蒸气。在空气中久置后能生成具有爆炸性的过氧化物。与酸类、碱类、氨、胺类、二氧化硫、硫脲、金属盐类、氧化剂等猛烈反应。在火场高温下能发生聚合放热，使容器破裂。 燃烧(分解)产物：一氧化碳、二氧化碳。 3.现场应急监测方法: 检气管法《化工企业空气中有害物质测定方法》，化学工业出版社 4.实验室监测方法: 监测方法 来源 类别 气相色谱法 HJ/T39-1999 固定污染源排气 气相色谱法 《水质分析大全》张宏陶等主编 水质 气相色谱法 《固体废弃物试验与分析评价手册》中国环境监测总站等译 固体废弃物 4-已基间苯二酚分光光度法 《空气和废气监测分析方法》国家环保局编 空气和废气 5.环境标准: 中国(TJ36-79) 车间空气中有害物质的最高容许浓度 0.3mg/m^3 中国(TJ36-79) 居住区大气中有害物质的最高容许浓度 0.10mg/m^3(一次值) 中国(GB16297-1996) 大气污染物综合排放标准 ①最高允许排放浓度(mg/m^3)： 16(表2)；20(表1) ②最高允许排放速率(kg/h)： 二级0.52～11(表2)；0.61～13(表1) 三级0.78～17(表2)；0.92～20(表1) ③无组织排放监控浓度限值(mg/m^3)： 0.40(表2)；0.50(表1) 中国(GB11607-89) 渔业水质标准 0.02mg/L 中国(GB5048-92) 农田灌溉水质标准 0.5mg/L(水作、旱作、蔬菜) 中国(待颁布) 饮用水源中有害物质的最高容许浓度 0.1mg/L 　 嗅觉阈浓度 0.48～4.1mg/m^3 6.应急处理处置方法: 一、泄漏应急处理 迅速撤离泄漏污染区人员至安全区，并立即进行隔离，小泄漏时隔离150米，大泄漏时隔离300米，严格限制出入。切断火源。建议应急处理人员戴自给正压式呼吸器，穿防毒服。不要直接接触泄漏物。尽可能切断泄漏源。防止进入下水道、排洪沟等限制性空间。小量泄漏：用活性面料或其它惰性材料吸收。也可以用大量水冲洗，洗水稀释后放入废水系统。大量泄漏：构筑围堤或挖坑收容；用泡沫覆盖，降低蒸气灾害。用防爆泵转移至槽车或专用收集器内，回收或运至废物处理场所处置。 二、防护措施 呼吸系统防护：可能接触其蒸气时，必须佩戴自吸过滤式防毒面具(全面罩)。 眼睛防护：呼吸系统防护中已作防护。 身体防护：穿防静电工作服。 手防护：戴橡胶手套。 其它：工作现场禁止吸烟、进食和饮水。工作毕，淋浴更衣。保持良好的卫生习惯。 三、急救措施 皮肤接触：立即脱去被污染的衣着，用大量流动清水冲洗，至少15分钟。 眼睛接触：立即提起眼睑，用大量流动清水或生理盐水彻底冲洗至少15分钟。就医。 吸入：迅速脱离现场至空气新鲜处。保持呼吸道通畅。如呼吸困难，给输氧。如呼吸停止，立即进行人工呼吸。就医。 食入：误服者用水漱口，给饮牛奶或蛋清。就医。 灭火方法：消防人员须戴好防毒面具，在安全距离以外，在上风向灭火。灭火剂：在抗溶性泡沫、干粉、二氧化碳、砂土。用水灭火无效。

毒性和生态

毒理学数据: 1.急性毒性 LD50：26mg/kg（大鼠经口）；14mg/kg（小鼠经口）；7mg/kg（兔经口）；200mg/kg（兔经皮） LC50：18mg/m^3（大鼠吸入，4h） 2.刺激性 家兔经皮：5mg，重度刺激。 家兔经眼：1mg，重度刺激。 3.亚急性与慢性毒性 大鼠持续接触本品浓度4.8mg/m^3,40h后，其肝脏的碱性磷酸酶活性升高。 4.致突变性 人细胞DNA损伤：30μmol/L。人淋巴细胞姐妹染色体交换：5μmol/L。 5.致畸性 如果直接在羊膜上给药，丙烯醛可致畸和产生胚胎毒性。 6.致癌性 IARC致癌性评论：G3，对人及动物致癌性证据不足。 7.其他 大鼠静脉最低中毒剂量（TDLo）：6mg/kg（孕后用药9d），胚泡植入后死亡率升高。 生态学数据: 1.生态毒性 LC50：0.046mg/L（24h）（褐鳟）；0.079mg/L（24h）（金鱼）；0.0173~0.022mg/L（96h）（黑头呆鱼）；0.23mg/L（24h），0.083mg/L（48h）（水蚤） LD50：＜0.08mg/L（24h）（金鱼，改良ASTMD1345） EC50：0.034mg/L（48h）（水蚤） 2.生物降解性 好氧生物降解（h）：168~672 厌氧生物降解（h）：672~2880 3.非生物降解性 空气中光氧化半衰期（h）：3.4~33.7 CHEMICAL IDENTIFICATION RTECS NUMBER : AS1050000 CHEMICAL NAME : Acrolein CAS REGISTRY NUMBER : 107-02-8 LAST UPDATED : 199712 DATA ITEMS CITED : 106 MOLECULAR FORMULA : C3-H4-O MOLECULAR WEIGHT : 56.07 WISWESSER LINE NOTATION : VH1U1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : Administration into the eye SPECIES OBSERVED : Human TYPE OF TEST : Open irritation test ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rabbit TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rabbit TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : Administration into the eye SPECIES OBSERVED : Rodent - rabbit TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : Administration into the eye SPECIES OBSERVED : Rodent - rabbit TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Human - man DOSE/DURATION : 1 ppm TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - lacrimation TYPE OF TEST : LCLo - Lowest published lethal concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Human DOSE/DURATION : 5500 ppb TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LCLo - Lowest published lethal concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Human DOSE/DURATION : 153 ppm/10M TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Human - child DOSE/DURATION : 300 ppb/2H TOXIC EFFECTS : Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi Lungs, Thorax, or Respiration - respiratory obstruction Lungs, Thorax, or Respiration - other changes TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 26 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 18 mg/m3/4H TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 4 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 50 mg/kg TOXIC EFFECTS : Behavioral - general anesthetic Liver - fatty liver degeneration TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 13900 ug/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Skin and Appendages - hair Nutritional and Gross Metabolic - weight loss or decreased weight gain TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 66 ppm/6H TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 9008 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 30 mg/kg TOXIC EFFECTS : Behavioral - general anesthetic Liver - fatty liver degeneration TYPE OF TEST : LCLo - Lowest published lethal concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Mammal - cat DOSE/DURATION : 1570 mg/m3/2H TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - cat DOSE/DURATION : 15 mg/kg TOXIC EFFECTS : Blood - other changes TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 7 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LCLo - Lowest published lethal concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 24 mg/m3/6H TOXIC EFFECTS : Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi Lungs, Thorax, or Respiration - emphysema Lungs, Thorax, or Respiration - acute pulmonary edema TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 250 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - dyspnea TYPE OF TEST : LCLo - Lowest published lethal concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 24 mg/m3/6H TOXIC EFFECTS : Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi Lungs, Thorax, or Respiration - emphysema Lungs, Thorax, or Respiration - acute pulmonary edema TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 178 ug/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Cardiac - other changes Lungs, Thorax, or Respiration - dyspnea TYPE OF TEST : LCLo - Lowest published lethal concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - hamster DOSE/DURATION : 1000 ppm/10M TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - lacrimation Lungs, Thorax, or Respiration - acute pulmonary edema Gastrointestinal - changes in structure or function of salivary glands TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - species unspecified DOSE/DURATION : 10 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Mammal - species unspecified DOSE/DURATION : 45 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 4 ppm/6H/62D-I TOXIC EFFECTS : Lungs, Thorax, or Respiration - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 4900 ppb/6H/13W-I TOXIC EFFECTS : Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Endocrine - changes in adrenal weight Related to Chronic Data - death TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 510 ug/m3/24H/9W-C TOXIC EFFECTS : Kidney, Ureter, Bladder - other changes in urine composition Blood - changes in leukocyte (WBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 3 ppm/6H/3W-I TOXIC EFFECTS : Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Endocrine - changes in spleen weight TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 3700 ppb/8H/6W-I TOXIC EFFECTS : Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Primate - monkey DOSE/DURATION : 3700 ppb/8H/6W-I TOXIC EFFECTS : Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi Related to Chronic Data - death TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 4900 ppb/6H/13W-I TOXIC EFFECTS : Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Lungs, Thorax, or Respiration - other changes Lungs, Thorax, or Respiration - changes in lung weight TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - hamster DOSE/DURATION : 4900 ppb/6H/13W-I TOXIC EFFECTS : Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Lungs, Thorax, or Respiration - other changes Lungs, Thorax, or Respiration - changes in lung weight TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - hamster DOSE/DURATION : 4 ppm/7H/52W-I TOXIC EFFECTS : Brain and Coverings - changes in brain weight Lungs, Thorax, or Respiration - changes in lung weight Liver - changes in liver weight TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 840 mg/kg SEX/DURATION : multigeneration TOXIC EFFECTS : Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous DOSE : 6 mg/kg SEX/DURATION : female 9 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) TYPE OF TEST : Specific locus test TYPE OF TEST : Sex chromosome loss and nondisjunction TYPE OF TEST : DNA inhibition TYPE OF TEST : Mutation test systems - not otherwise specified MUTATION DATA TYPE OF TEST : DNA inhibition TEST SYSTEM : Mammal - species unspecified Lymphocyte REFERENCE : FEBLAL FEBS Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1968- Volume(issue)/page/year: 30,286,1973 *** REVIEWS *** ACGIH TLV-STEL 0.69 mg/m3 (0.3 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 0.23 mg/m3 (0.1 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 19,479,1979 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 36,133,1985 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 36,133,1985 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 63,337,1995 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 63,337,1995 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,78,1987 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 63,339,1995 TOXICOLOGY REVIEW EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 11,163,1975 TOXICOLOGY REVIEW CMTVAS Cahiers de Medecine du Travail. (Association Professionnelle Belge des Medecine du Travail, rue du Bultia, 6280 Gerpinnes, Belgium) V.1- 1963- Volume(issue)/page/year: 10(3),49,1973 TOXICOLOGY REVIEW MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 47,115,1978 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 MSHA STANDARD-air:TWA 0.1 ppm (0.25 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,5,1971 OSHA PEL (Gen Indu):8H TWA 0.1 ppm (0.25 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 0.1 ppm (0.25 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 0.1 ppm (0.25 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 0.1 ppm (0.25 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 0.1 ppm (0.25 mg/m3) JAN 1993 OEL-AUSTRALIA:TWA 0.1 ppm (0.25 mg/m3);STEL 0.3 ppm (0.8 mg/m3) JAN 1993 OEL-AUSTRIA:TWA 0.1 ppm (0.25 mg/m3) JAN 1993 OEL-BELGIUM:TWA 0.1 ppm (0.23 mg/m3);STEL 0.3 ppm (0.69 mg/m3) JAN 1993 OEL-DENMARK:TWA 0.1 ppm (0.25 mg/m3) JAN 1993 OEL-FINLAND:STEL 0.1 ppm (0.25 mg/m3);Skin JAN 1993 OEL-FRANCE:STEL 0.1 ppm (0.25 mg/m3) JAN 1993 OEL-GERMANY:TWA 0.1 ppm (0.25 mg/m3) JAN 1993 OEL-HUNGARY:TWA 0.25 mg/m3;STEL 0.5 mg/m3 JAN 1993 OEL-INDIA:TWA 0.1 ppm (0.25 mg/m3);STEL 0.3 ppm (0.8 mg/m3) JAN 1993 OEL-JAPAN:TWA 0.1 ppm (0.23 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 0.1 ppm (0.25 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 0.1 ppm (0.25 mg/m3) JAN 1993 OEL-POLAND:TWA 0.5 mg/m3 JAN 1993 OEL-RUSSIA:TWA 0.1 ppm;STEL 0.2 mg/m3 JAN 1993 OEL-SWEDEN:TWA 0.1 ppm (0.2 mg/m3);STEL 0.3 ppm (0.7 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 0.1 ppm (0.25 mg/m3);STEL 0.2 ppm JAN 1993 OEL-TURKEY:TWA 0.1 ppm (0.25 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 0.1 ppm (0.25 mg/m3);STEL 0.3 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO ACROLEIN-air:10H TWA 0.1 ppm;STEL 0.3 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 03530 No. of Facilities: 845 (estimated) No. of Industries: 16 No. of Occupations: 25 No. of Employees: 7299 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 03530 No. of Facilities: 37 (estimated) No. of Industries: 4 No. of Occupations: 18 No. of Employees: 1298 (estimated) No. of Female Employees: 5 (estimated)

安全

• 符号: GHS02, GHS05, GHS06, GHS09
• 信号词: Danger
• 危害声明: H225-H300 + H330-H311-H314-H410
• 补充危害声明: Corrosive to the respiratory tract.
• 警示性声明: P260-P280-P301 + P310 + P330-P304 + P340 + P310-P305 + P351 + P338-P370 + P378
• 个人防护装备: Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US)
• 危害码 (欧洲): F:Flammable
• 风险声明 (欧洲): R11;R24/25;R26;R34;R50
• 安全声明 (欧洲): S23-S26-S28-S36/37/39-S45-S61
• 危险品运输编码: UN 1092 6.1/PG 1
• WGK德国: 3
• RTECS号: AS1050000
• 包装等级: I
• 危险类别: 6.1
• 海关编码: 2912190030

合成路线

上下游产品

上游产品  10
56-81-5 187737-37-7 107-18-6 74-98-6
50-00-0 75-07-0 123-38-6 57357-83-2
116-09-6 75-56-9
下游产品  10
10500-11-5 104951-29-3 10140-89-3 105582-16-9
1121-54-6 57620-49-2 4427-96-7 3360-16-5
53400-41-2 4393-06-0

制备

1.实验室制法 将甘油与硫酸氢钾或硫酸镁，硼酸，三氧化铝在215～235 ℃共热，将反应生成的丙烯醛气体蒸出并经冷凝收集，得粗品。将粗品加10%磷酸氢钠溶液调pH值至6，进行分馏，收集50～75 ℃馏分，即得丙烯醛精品。
投料比（mol）：甘油：硫酸氢钾：硫酸钾＝1：0.5：0.026。

2.工业制法 目前工业上主要采用丙烯催化空气氧化法。
将丙烯、空气和水蒸气按一定比例混合后与催化剂一起送入固定床反应器，在0.1~0.2 MPa、350～450 ℃下进行反应，接触时间0.8 s，反应释放的热量回收用以蒸汽的生产。反应生成的气体混合物用水急冷，从急冷塔出来的尾气放空前经过洗涤。从急冷塔塔底出来的有机液进汽提塔，汽提出丙烯醛和其他轻组分，然后用蒸馏法从粗丙烯醛中除去水和乙醛。反应式：
投料比（mol）丙烯：空气：水蒸气＝1：10：2。

3.乙醛和甲醛在催化剂作用下，经气相催化缩合制得丙烯醛。或者在催化剂的作用下，将丙烯用空气氧化制丙烯醛，副产物为乙酸、乙醛、丙烯酸和二氧化碳。

海关

海关编码	2909199090
中文概述	2909199090. 其他无环醚及其卤化衍生物（包括磺化，硝化或亚硝化衍生物）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	2909199090. other acyclic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%