1943-79-9

• 常用中文名：甲基氨基甲酸苯酯
• 常用英文名：Carbamic acid,N-methyl-, phenyl ester
• CAS号：1943-79-9
• 分子式：C₈H₉NO₂
• 分子量：151.16300
• 发布时间：2018-10-01 10:56:14
• 更新时间：2024-01-01 23:14:44

名称

• 中文名: 甲基氨基甲酸苯酯
• 英文名: phenyl N-methylcarbamate
• 中文别名: 苯基 甲基氨基甲酸酯
• 英文别名: N-Methylphenylcarbamate; PHENYL METHYLCARBAMATE; Phenol,methylcarbamate; Phenmec; Methyl-carbamidsaeure-phenylester; Carbamic acid,methyl-,phenyl ester; DRC 3345; carbamate de phenol; Phenyl monomethylcarbamate; phenyl-N-methyl-carbamate; Methylcarbamic acid phenyl ester

物化性质

• 密度: 1.112g/cm3
• 沸点: 215.4ºC at 760 mmHg
• 分子式: C₈H₉NO₂
• 分子量: 151.16300
• 闪点: 84.1ºC
• 精确质量: 151.06300
• PSA: 38.33000
• LogP: 1.79570
• 蒸汽压: 0.148mmHg at 25°C
• 折射率: 1.518
• 储存条件: 室温

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : FC6800000 CHEMICAL NAME : Carbamic acid, methyl-, phenyl ester CAS REGISTRY NUMBER : 1943-79-9 BEILSTEIN REFERENCE NO. : 2045075 LAST UPDATED : 199710 DATA ITEMS CITED : 8 MOLECULAR FORMULA : C8-H9-N-O2 MOLECULAR WEIGHT : 151.18 WISWESSER LINE NOTATION : 1MVOR HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : Administration into the eye SPECIES OBSERVED : Rodent - rabbit REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0528508 ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 540 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : BWHOA6 Bulletin of the World Health Organization. (WHO, Pub. Center USA, 49 Sheridan Ave., Albany, NY 12210) Volume(issue)/page/year: 44,241,1971 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 357 mg/kg TOXIC EFFECTS : Behavioral - general anesthetic Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - other changes REFERENCE : BWHOA6 Bulletin of the World Health Organization. (WHO, Pub. Center USA, 49 Sheridan Ave., Albany, NY 12210) Volume(issue)/page/year: 44,241,1971 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 13600 ug/kg TOXIC EFFECTS : Behavioral - general anesthetic Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - other changes REFERENCE : BWHOA6 Bulletin of the World Health Organization. (WHO, Pub. Center USA, 49 Sheridan Ave., Albany, NY 12210) Volume(issue)/page/year: 44,241,1971 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >50 mg/kg TOXIC EFFECTS : Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - coma Lungs, Thorax, or Respiration - respiratory stimulation REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB158-508 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Bird - wild bird species DOSE/DURATION : >100 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953- Volume(issue)/page/year: 15,287,1967

安全

• 海关编码: 2924299090

合成路线

1885-14-9 74-89-5 ~88% 1943-79-9

文献：Takeda Pharmaceutical Company Limited Patent: EP1500658 A1, 2005 ; Location in patent: Page 51-52 ; EP 1500658 A1

593-51-1 1885-14-9 ~61% 1943-79-9

文献：Eisai Co., Ltd. Patent: EP1522540 A1, 2005 ; Location in patent: Page/Page column 48 ; EP 1522540 A1

624-83-9 108-95-2 ~79% 1943-79-9

文献：Ivanov; Smirnova Pharmaceutical Chemistry Journal, 1997 , vol. 31, # 1 p. 12 - 14

6642-30-4 108-95-2 ~56% 1943-79-9

文献：Deshpande, Sunita R.; Likhite, Anjali P.; Rajappa, Srinivasachari Tetrahedron, 1994 , vol. 50, # 34 p. 10367 - 10370

30379-59-0 108-95-2 ~71% 1943-79-9

文献：Deshpande, Sunita R.; Likhite, Anjali P.; Rajappa, Srinivasachari Tetrahedron, 1994 , vol. 50, # 34 p. 10367 - 10370

14128-35-9 108-95-2 ~32% 1943-79-9

文献：Joshi, Uday M.; Patkar, Laxmikant N.; Rajappa, Srinivasachari Synthetic Communications, 2004 , vol. 34, # 1 p. 33 - 39

1885-14-9 ~% 1943-79-9

文献：Sigmund; Pfleiderer Helvetica Chimica Acta, 1994 , vol. 77, # 5 p. 1267 - 1280

161001-97-4 ~% 1943-79-9

文献：Sigmund; Pfleiderer Helvetica Chimica Acta, 1994 , vol. 77, # 5 p. 1267 - 1280

161001-98-5 ~% 1943-79-9

文献：Sigmund; Pfleiderer Helvetica Chimica Acta, 1994 , vol. 77, # 5 p. 1267 - 1280

海关

海关编码	2924299090
中文概述	2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 包装
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%