123441-03-2

• 常用中文名：利凡斯的明
• 常用英文名：Rivastigmine
• CAS号：123441-03-2
• 分子式：C₁₄H₂₂N₂O₂
• 分子量：250.34
• 相关类别： 原料药 神经系统用药 脑代谢调节药
• 发布时间：2018-08-31 13:02:28
• 更新时间：2024-01-02 19:44:05
• Rivastigmine酒石酸盐是胆碱酯酶抑制剂,IC50为5.5 uM,还能抑制丁酰胆碱酯酶和乙酰胆碱酯酶。

名称

• 中文名: 利凡斯的明
• 英文名: rivastigmine
• 中文别名: 利斯的明; N-乙基-N-甲基-氨基甲酸 3-[(S)-1-(二甲氨基)乙基]苯酯
• 英文别名: Carbamic acid, N-ethyl-N-methyl-, 3-[(1S)-1-(dimethylamino)ethyl]phenyl ester; [3-[(1S)-1-(dimethylamino)ethyl]phenyl] N-ethyl-N-methylcarbamate; MFCD03700731; (S)-N-ethyl-3-[(1-dimethylamino)ethyl]-N-methylphenylcarbamate; Rivastigmine; N-Ethyl-N-methylcarbamic acid 3-[(1S)-1-(dimethylamino)ethyl]phenyl-ester; (S)-3-(1-(dimethylamino)ethyl)phenyl ethyl(methyl)carbamate; Ethylmethylcarbamic acid 3-[(1S)-1-(dimethylamino)ethyl]phenyl ester; 3-((1S)-1-(Dimethylamino)ethyl)phenyl ethylmethylcarbamate; carbamic acid, ethyl(methyl)-, 3-[(1S)-1-(dimethylamino)ethyl]phenyl ester; 3-[(1S)-1-(Dimethylamino)ethyl]phenyl ethyl(methyl)carbamate

物化性质

• 密度: 1.0±0.1 g/cm3
• 沸点: 316.2±34.0 °C at 760 mmHg
• 分子式: C₁₄H₂₂N₂O₂
• 分子量: 250.34
• 闪点: 145.0±25.7 °C
• PSA: 147.84000
• LogP: 2.14
• 外观性状: 液体;Colorless to Light yellow clear liquid
• 蒸汽压: 0.0±0.7 mmHg at 25°C
• 折射率: 1.518
• 储存条件: 0-10°C;存放于惰性气体之中;避免空气,加热
• 水溶解性: 水溶性：微溶；混溶：乙醇,甲醇

生物活性

• 描述: Rivastigmine酒石酸盐是胆碱酯酶抑制剂,IC50为5.5 uM,还能抑制丁酰胆碱酯酶和乙酰胆碱酯酶。
• 相关类别:
  信号通路 >> 神经信号通路 >> 疼痛
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Kurz A, Farlow M, Lefèvre G. Pharmacokinetics of a novel transdermal rivastigmine patch for the treatment of Alzheimer's disease: a review. Int J Clin Pract. 2009 May;63(5):799-805.

  [2]. Polinsky RJ. Clinical pharmacology of rivastigmine: a new-generation acetylcholinesterase inhibitor for the treatment of Alzheimer's disease. Clin Ther. 1998 Jul-Aug;20(4):634-47.

  [3]. Stryjer R, Ophir D, Bar F et al. Rivastigmine treatment for the prevention of electroconvulsive therapy-induced memory deficits in patients with schizophrenia. Clin Neuropharmacol. 2012 Jul-Aug;35(4):161-4.

  [4]. Han HJ, Lee JJ, Park SA et al. Efficacy and safety of switching from oral cholinesterase inhibitors to the rivastigmine transdermal patch in patients with probable Alzheimer's disease. J Clin Neurol. 2011 Sep;7(3):137-42.

安全

• 危害码 (欧洲): Xi

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