15876-67-2

• 常用中文名：溴地斯的明
• 常用英文名：distigmine bromide
• CAS号：15876-67-2
• 分子式：C₂₂H₃₂Br₂N₄O₄
• 分子量：576.32
• 相关类别： 研究领域 神经疾病
• 发布时间：2018-02-23 08:00:00
• 更新时间：2024-01-02 14:32:49
• Ubretid是一种有效的血浆胆碱酯酶抑制剂。因此,乌布雷特延缓了苏沙甲铵的水解并延长其作用,类似于其他抗胆碱酯酶药物,如吡啶斯的明和多奈哌齐的作用。乌布雷特有可能用于研究尿潴留延长舒沙霉素的作用。Ubretid通常用于研究重症肌无力和膀胱排空困难[1]。

名称

• 中文名: 溴地斯的明
• 英文名: (1-methylpyridin-1-ium-3-yl) N-methyl-N-[6-[methyl-(1-methylpyridin-1-ium-3-yl)oxycarbonylamino]hexyl]carbamate,dibromide
• 英文别名: Distigminbromid; EINECS 240-013-0; Distigmindibromid; Bromure de distigmine [INN-French]; Hexamethylenebis[N-methylcarbaminoyl-1-methyl-3-hydroxypyridinium Bromide]; Hexamethylenebis[methylcarbamic Acid] Ester of 3-Hydroxy-1-methylpyridinium Bromide; 3,3'-{Hexane-1,6-diylbis[(methylcarbamoyl)oxy]}bis(1-methylpyridinium) dibromide; Ubretid; Distigmine; 3,3'-{1,6-Hexanediylbis[(methylcarbamoyl)oxy]}bis(1-methylpyridinium) dibromide; N,N'-Dimethyl-N,N'-bis-(1-methyl-pyridinium-3-yloxycarbonyl)-hexandiyldiamin,Dibromid; N,N'-dimethyl-N,N'-bis-(1-methyl-pyridinium-3-yloxycarbonyl)-hexanediyldiamine,dibromide; Hexamethylenebis[N-methylcarbamic Acid Ester Bromomethylate]; Hexamarium; Pyridinium, 3,3'-[1,6-hexanediylbis[(methylimino)carbonyloxy]]bis[1-methyl-, bromide (1:2); 3-Hydroxy-1-methylpyridinium Bromide Hexamethylenebis[methylcarbamate]; Ubritil; distigmine bromide; BC 51; Distigmini bromidum [INN-Latin]; Bromuro de distigmina [INN-Spanish]; 3,3'-[1,6-Hexanediylbis[(methylimino)carbonyl]oxy]bis[1-methylpyridinium]dibromide

物化性质

• 分子式: C₂₂H₃₂Br₂N₄O₄
• 分子量: 576.32
• 精确质量: 574.079041
• PSA: 66.84000
• 储存条件: 室温，干燥密封

生物活性

• 描述: Ubretid是一种有效的血浆胆碱酯酶抑制剂。因此,乌布雷特延缓了苏沙甲铵的水解并延长其作用,类似于其他抗胆碱酯酶药物,如吡啶斯的明和多奈哌齐的作用。乌布雷特有可能用于研究尿潴留延长舒沙霉素的作用。Ubretid通常用于研究重症肌无力和膀胱排空困难[1]。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Isono S, et al. Ubretid (distigmine bromide) taken to treat urinary retention prolongs the effect of suxamethonium. J Anesth. 2008;22(3):337.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UU5277000 CHEMICAL NAME : Pyridinium, 3-hydroxy-1-methyl-, bromide, hexamethylenebis(methylcarbamate) CAS REGISTRY NUMBER : 15876-67-2 LAST UPDATED : 199506 DATA ITEMS CITED : 10 MOLECULAR FORMULA : C22-H32-N4-O4.2Br MOLECULAR WEIGHT : 576.40 WISWESSER LINE NOTATION : T6KJ A1 COVN1&6N1&VO- DT6KJ A1 &E 2 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 900 ug/kg/3D TOXIC EFFECTS : Autonomic Nervous System - parasympatholytic Vascular - other changes Lungs, Thorax, or Respiration - respiratory depression REFERENCE : JJTOEX Japanese Journal of Toxicology. (Yakugyo Jihosha, Hokushin Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo, 101, Japan) V.1- 1988- Volume(issue)/page/year: 4,383,1991 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 700 ug/kg/7D-I TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - visual field changes Sense Organs and Special Senses (Eye) - diplopia Behavioral - hallucinations, distorted perceptions REFERENCE : BJCPAT British Journal of Clinical Practice. (Medical News Group, 1 Bedford St., London WC2E 9HD, UK) V.10(10)- 1956- Volume(issue)/page/year: 48,103,1994 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 10 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 3,68,1969 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 740 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,349,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1080 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,349,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 740 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 3,68,1969 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 10500 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 3,68,1969 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 310 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,349,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 900 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,349,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 300 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 3,68,1969

合成路线

99191-71-6 ~% 15876-67-2

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