79-64-1

• 常用中文名：双甲乙炔睾酮
• 常用英文名：dimethisterone
• CAS号：79-64-1
• 分子式：C₂₃H₃₂O₂
• 分子量：340.49900
• 相关类别： 原料药 激素及调节内分泌功能类药 雌激素及孕激素类药
• 发布时间：2018-06-16 14:15:36
• 更新时间：2024-04-03 17:52:10

名称

• 中文名: 双甲乙炔睾酮
• 英文名: (6S,8R,9S,10R,13S,14S,17S)-17-hydroxy-6,10,13-trimethyl-17-prop-1-ynyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
• 中文别名: 地美炔酮
• 英文别名: Secrosteron; Dimethisterone; Dimethisteron; Dimethisterone anhydrous; 6a,21-dimethylethisterone; Lutogan

物化性质

• 密度: 1.11g/cm3
• 沸点: 479ºC at 760 mmHg
• 熔点: 102°
• 分子式: C₂₃H₃₂O₂
• 分子量: 340.49900
• 闪点: 203.5ºC
• 精确质量: 340.24000
• PSA: 37.30000
• LogP: 4.51870
• 折射率: 1.566

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : BV8510000 CHEMICAL NAME : Androst-4-en-3-one, 17-beta-hydroxy-6-alpha-methyl-17-(1-propynyl)- CAS REGISTRY NUMBER : 79-64-1 LAST UPDATED : 199510 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C23-H32-O2 MOLECULAR WEIGHT : 340.55 WISWESSER LINE NOTATION : L E5 B666 OV MUTJ A1 E1 FQ F1UU2 L1 -A&L -B&AEF HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 100 mg/kg SEX/DURATION : female 17-20 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - urogenital system REFERENCE : ECJPAE Endocrinologia Japonica. (Japan Pub. Trading Co., Ltd., POB 5030, Tokyo International, Tokyo, Japan) V.1- 1954- Volume(issue)/page/year: 24,77,1977 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 175 mg/kg SEX/DURATION : female 15-21 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - urogenital system REFERENCE : ACENA7 Acta Endocrinologica (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) V.1- 1948- Volume(issue)/page/year: 38,128,1961 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 70 mg/kg SEX/DURATION : female 14 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Fertility - other measures of fertility REFERENCE : CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 5,57,1972 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 28 mg/kg SEX/DURATION : female 14 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - uterus, cervix, vagina REFERENCE : CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 5,57,1972 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 21,377,1979