7411-49-6

• 常用中文名：3,3'-二氨基联苯胺四盐酸盐
• 常用英文名：3,3',4,4'-Biphenyltetramine tetrahydrochloride
• CAS号：7411-49-6
• 分子式：C₁₂H₁₈Cl₄N₄
• 分子量：360.110
• 相关类别： 有机原料 氨基化合物 无环单胺、多胺及其衍生物和盐
• 发布时间：2018-08-17 06:10:30
• 更新时间：2024-01-03 20:15:33
• 3,3'-Diaminobenzidine(DAB)是有机化合物,具有化学和热力学稳定性,可用于核酸和蛋白的免疫组化染色。

名称

• 中文名: 3,3'-二氨基联苯胺四盐酸盐
• 英文名: 3,3',4,4'-Biphenyltetramine tetrahydrochloride
• 中文别名: 3,3'-二氨基联苯氨四盐酸盐; 3,3''-二氨基联苯胺四盐酸盐; 3,3’-二氨基联苯胺,盐酸盐
• 英文别名: DAB TABLET; DAB SUBSTRATE; DAB-HCL; Biphenyl-3,3',4,4'-tetramine tetrahydrochloride; DAB TETRAHYDROCHLORIDE; DAB; 3,3',4,4'-Biphenyltetramine tetrahydrochloride; DAB,tetrahydrochloride3; 3,3`-Diaminobenzidine tetrahydrochloride; DAB EASY tablets; DAB anhydrous; MFCD00012969; [1,1'-Biphenyl]-3,3',4,4'-tetramine, hydrochloride (1:4); DAB 4HCL; EINECS 231-018-9; DAB WITH METAL ENHANCER

物化性质

• 沸点: 481.7ºC at 760 mmHg
• 熔点: 300°C
• 分子式: C₁₂H₁₈Cl₄N₄
• 分子量: 360.110
• 闪点: 282.7ºC
• 精确质量: 358.028564
• PSA: 104.08000
• LogP: 7.21520
• 外观性状: 灰色至紫色-棕色粉末
• 储存条件:

  密封于2-8℃阴凉干燥环境。

• 稳定性:

  如果遵照规格使用和储存则不会分解。

• 水溶解性: Soluble
• 分子结构:

  1、摩尔折射率：无可用

  2、 摩尔体积（cm³/mol）： 无可用

  3、 等张比容（90.2K）：无可用

  4、 表面张力（dyne/cm）：无可用

  5、 极化率：无可用

• 计算化学:

  1、 疏水参数计算参考值（XlogP）：无可用

  2、 氢键供体数量：8

  3、 氢键受体数量：4

  4、 可旋转化学键数量：1

  5、 拓扑分子极性表面积（TPSA）：104

  6、 重原子数量：20

  7、 表面电荷：0

  8、 复杂度：209

  9、 同位素原子数量：0

  10、 确定原子立构中心数量：0

  11、 不确定原子立构中心数量：0

  12、 确定化学键立构中心数量：0

  13、 不确定化学键立构中心数量：0

  14、 共价键单元数量：5

• 更多:

  1. 性状：无可用

  2. 密度（g/mL,25/4℃）： 无可用

  3. 相对蒸汽密度（g/mL,空气=1）：无可用

  4. 熔点（ºC）：125

  5. 沸点（ºC,常压）：无可用

  6. 沸点（ºC,5.2kPa）： 无可用

  7. 折射率： 无可用

  8. 闪点（ºC）： 无可用

  9. 比旋光度（º）：无可用

  10. 自燃点或引燃温度（ºC）：无可用

  11. 蒸气压（kPa,25ºC）：无可用

  12. 饱和蒸气压（kPa,60ºC）：无可用

  13. 燃烧热（KJ/mol）：无可用

  14. 临界温度（ºC）：无可用

  15. 临界压力（KPa）：无可用

  16. 油水（辛醇/水）分配系数的对数值：无可用

  17. 爆炸上限（%,V/V）：无可用

  18. 爆炸下限（%,V/V）： 无可用

  19. 溶解性：可溶于水

生物活性

• 描述: 3,3'-Diaminobenzidine(DAB)是有机化合物,具有化学和热力学稳定性,可用于核酸和蛋白的免疫组化染色。
• 相关类别:
  信号通路 >> 其他 >> 其他
  染料试剂
  研究领域 >> 其他
• 参考文献:

  [1]. Hannetz Roschzttardtz, et al. Plant Cell Nucleolus as a Hot Spot for Iron.

MSDS

Name: 3 3 -Diaminobenzidine tetrahydrochloride dihydrate 98% Material Safety Data Sheet Synonym: 3,3',4,4'-Biphenyltetramine tetrahydrochloride; 3,3',4,4'-Tetraaminobiphenyl tetrahydrochloride CAS: 7411-49-6 Section 1 - Chemical Product MSDS Name:3 3 -Diaminobenzidine tetrahydrochloride dihydrate 98% Material Safety Data Sheet Synonym:3,3',4,4'-Biphenyltetramine tetrahydrochloride; 3,3',4,4'-Tetraaminobiphenyl tetrahydrochloride Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 7411-49-6 3,3'-Diaminobenzidine tetrahydrochlori 98 231-018-9 Hazard Symbols: XI Risk Phrases: 33 36/37/38 Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Danger of cumulative effects. Irritating to eyes, respiratory system and skin.Cancer suspect agent. Potential Health Effects Eye: Causes eye irritation. May cause chemical conjunctivitis. Skin: Causes skin irritation. Ingestion: May cause gastrointestinal irritation with nausea, vomiting and diarrhea. Inhalation: Causes respiratory tract irritation. Can produce delayed pulmonary edema. Chronic: Effects may be delayed. Animal studies have reported the development of tumors. Potential cancer hazard. Section 4 - FIRST AID MEASURES Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Ingestion: Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Treat symptomatically and supportively. Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing Media: Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions. Provide ventilation. Section 7 - HANDLING and STORAGE Handling: Remove contaminated clothing and wash before reuse. Use only in a well-ventilated area. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Storage: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep refrigerated. (Store below 4C/39F.) Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 7411-49-6: United States OSHA: (Cancer suspect agent - see 29 CFR 1910.1010) (listed under Benzidine). France - VME: (listed as benzidine): 0.001 ppm VME; 0.008 mg/m3 V Germany: (listed as benzidine): 0.001 ppm VME; 0.008 mg/m3 VME Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Powder Color: off-white to gray Odor: none reported pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: 280 deg C Autoignition Temperature: Not applicable. Flash Point: Not applicable. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: Specific Gravity/Density: Molecular Formula: C12H14N4.4HCl.2H2O Molecular Weight: 396.14 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: Incompatible materials, strong oxidants, strong oxidants. Incompatibilities with Other Materials: Strong oxidizing agents. Hazardous Decomposition Products: Hydrogen chloride, nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen. Hazardous Polymerization: Has not been reported. Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 7411-49-6: DV8753000 LD50/LC50: Not available. Carcinogenicity: 3,3'-Diaminobenzidine tetrahydrochloride - California: carcinogen, initial date 2/27/87 (listed as Benzidine). NTP: Known carcinogen (listed as Benzidine). IARC: Group 1 carcinogen (listed as Benzidine). Other: See actual entry in RTECS for complete information. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Not regulated as a hazardous material. IMO Not regulated as a hazardous material. RID/ADR Shipping Name: Not regulated. Hazard Class: UN Number: Packing group: Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: XI Risk Phrases: R 33 Danger of cumulative effects. R 36/37/38 Irritating to eyes, respiratory system and skin. Safety Phrases: S 22 Do not breathe dust. S 24/25 Avoid contact with skin and eyes. WGK (Water Danger/Protection) CAS# 7411-49-6: No information available. Canada CAS# 7411-49-6 is listed on Canada's DSL List. CAS# 7411-49-6 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 7411-49-6 is listed on the TSCA inventory. SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

毒理学数据: 1 。 试验方法：口服 摄入剂量： 260 mg/kg/78W-C 测试对象：啮齿动物-鼠 毒性类型：瘤 毒性作用： 1.模棱两可瘤代理RTECS标准 2.肝脏肿瘤 2 。 试验方法：口服 摄入剂量： 260 mg/kg/78W-C 测试对象：啮齿动物-鼠 毒性类型：瘤 毒性作用： 1.肿瘤 2.肺 ，胸部或呼吸-肿瘤 3 。 试验方法：口服 摄入剂量： 520 mg/kg/78W-C 测试对象：啮齿动物-鼠 毒性类型：瘤 毒性作用： 1. 肿瘤 2.肺，胸部或呼吸-肿瘤 4 。 试验方法：腹腔 摄入剂量： 330毫克/千克 测试对象：啮齿动物-鼠 毒性类型：急性 毒性作用： 详细的毒副作用没有报告以外的其他致死剂量值 生态学数据: 该物质对环境可能有危害，对水体应给予特别注意。 CHEMICAL IDENTIFICATION RTECS NUMBER : DV8753000 CHEMICAL NAME : 3,3',4,4'-Biphenyltetramine, tetrahydrochloride CAS REGISTRY NUMBER : 7411-49-6 LAST UPDATED : 199701 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C12-H14-N4.4Cl-H MOLECULAR WEIGHT : 360.14 WISWESSER LINE NOTATION : ZR BZ DR CZ DZ &GH 4 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 330 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NCIBR* Progress Report for Contract No. NIH-NCI-E-68-1311, Submitted to the National Cancer Institute by Bio-Research Consultants, Inc. (9 Commercial Ave., Cambridge, MA 02141) Volume(issue)/page/year: NCI-E-68-1311,1973 ** TUMORIGENIC DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 260 gm/kg/78W-C TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors REFERENCE : JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC. Volume(issue)/page/year: 2(2),325,1978 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 260 gm/kg/78W-C TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors REFERENCE : JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC. Volume(issue)/page/year: 2(2),325,1978 TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 520 gm/kg/78W-C TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors REFERENCE : JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC. Volume(issue)/page/year: 2(2),325,1978

安全

• 符号: GHS07, GHS08
• 信号词: Danger
• 危害声明: H302-H319-H341-H350
• 警示性声明: P201-P280-P301 + P312 + P330-P305 + P351 + P338-P308 + P313-P337 + P313
• 危害码 (欧洲): Xn:Harmful;
• 风险声明 (欧洲): R22;R36/37/38;R40
• 安全声明 (欧洲): S7-S16-S24-S33-S36/37-S45-S24/25-S22
• 危险品运输编码: UN 3316 9/PG 2
• WGK德国: 3
• RTECS号: DV8753000
• 危险类别: 9.0