123-39-7

• 常用中文名：N-甲基甲酰胺
• 常用英文名：N-methylformamide
• CAS号：123-39-7
• 分子式：C₂H₅NO
• 分子量：59.067
• 相关类别： 有机原料 氨基化合物 酰胺类化合物
• 发布时间：2018-08-24 20:57:47
• 更新时间：2024-01-01 20:53:48
• 【用途一】
  用于合成高效低毒农药单甲脒、双甲脒等，用作有机合成的反应溶剂和精制溶剂，广泛用于医药、染料、香料等
  【用途二】
  N-甲基甲酰胺是一种重要的有机合成原料，用于农药杀虫杀螨剂单甲脒、双甲脒的合成，也用于生产医药、合成革、人造革以及用作化纤纺织溶剂等。
  【用途三】
  用作有机合成原料，用于农药杀虫药剂、医药、合成革、人造革等的合成；以及用作化纤纺织溶剂等。
  【用途四】
  是重要的有机化工原料和中间体，是一种性能较好的有机溶剂。用于合成高效低毒的单甲咪，双甲咪等。用作有机合成的反应溶剂和精制溶剂。还广泛用于医药、染料、香料及电解、电镀工业等。

名称

• 中文名: N-甲基甲酰胺
• 英文名: N-methylformamide
• 中文别名: 甲基甲酰胺; N-甲基-甲酰胺; 甲基替甲酰胺; 乙酰胺
• 英文别名: N-Methylformamid; methanimidic acid, methyl-; METHYLFORMAMIDE; formamide, methyl-; ek7011; X 188; METHYL FORMAMIDE; HCONHCH3; N-methyl-carboxamide; 4-04-00-00170 (Beilstein Handbook Reference); Formamide, N-methyl- (8CI 9CI); Formamide, N-methyl-; N-METHYL-FORMAMIDE; Ethanamide; N-METHYLFORMAMIDE/N-FORMYLMETHYLAMINE; N-Formylmethylamine; N-Methylformamide; Acetamide; Formylmethylamine; N-METHYL FORMAMIDE; n-methyl-formamid; monomethylformamide; Methylcarbylamine; monomethyl-formamide; MFCD00003280; EINECS 204-624-6

物化性质

• 密度: 1.011
• 沸点: 199-201 ºC
• 熔点: -4 ºC
• 分子式: C₂H₅NO
• 分子量: 59.067
• 闪点: 111 ºC
• 精确质量: 59.037113
• PSA: 29.10000
• LogP: -0.60
• 外观性状: 透明无色液体
• 蒸汽压: 0.8±0.3 mmHg at 25°C
• 折射率: 1.431-1.433
• 储存条件:

  1.200kg铁桶包装。密封贮存，防止泄漏，避免雨淋、曝晒，严重撞击、摩擦。远离火种、热源。一级易燃液体，危规号61152。

• 稳定性:

  1.无色透明粘稠油状液体。溶于水，也能溶解无机盐类，具有吸湿性，在酸性或碱性溶液中容易分解。有氨的气味。

  化学性质与氯化氢作用能形成两种盐；在非极性溶剂中生成HCONHCH3·HCl；无溶剂时生成(HCONHCH3)2·HCl。与金属钠在室温下几乎不作用。受酸或碱的作用则发生水解。酸性水解速度是甲酰胺>N-甲基甲酰胺>N,N-二甲基甲酰胺。碱性水解速度是甲酰胺-N-甲基甲酰胺>N,N-二甲基甲酰胺。

  2. 存在于主流烟气中。

• 水溶解性: miscible
• 分子结构:

  1、 摩尔折射率：15.09

  2、 摩尔体积（cm³/mol）：67.6

  3、 等张比容（90.2K）：148.5

  4、 表面张力（dyne/cm）：23.2

  5、 极化率（10^-24cm³）：5.98

• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:1

  3.氢键受体数量:1

  4.可旋转化学键数量:0

  5.互变异构体数量:2

  6.拓扑分子极性表面积29.1

  7.重原子数量:4

  8.表面电荷:0

  9.复杂度:20

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

• 更多:

  1. 性状：无色透明液体。有氨味。

  2. 沸点（ºC,101.3kPa）：198~199

  3. 熔点（ºC）：-4

  4. 相对密度（g/mL,15/4ºC）：1.0075

  5. 相对密度（g/mL,25/4ºC）：1.011

  6. 折射率（20ºC）：1.432

  7. 折射率（25ºC）：1.4300

  8. 黏度（mPa·s,25ºC）：1.732

  9. 黏度（mPa·s,35ºC）：1.468

  10. 黏度（mPa·s,45ºC）：1.261

  11. 闪点（ºC）:111

  12. 电导率（S/m）：8×10^-7

  13. 体膨胀系数（K^-1,25ºC）：0.0008691

  14.溶解性：能与水、乙醇相混溶，微溶于苯、三氯甲烷和乙醚。

MSDS

第一部分：化学品名称 化学品中文名称: N-甲基甲酰胺；甲基替甲酰胺 化学品英文名称: N-Methylformamide CAS No.: 123-39-7 分子式: C2H5NO 分子量: 59.07 第二部分：成分/组成信息 化学品名称：N-甲基甲酰胺；甲基替甲酰胺 有害物成分: N-甲基甲酰胺 含量: 100% CAS No.: 123-39-7 第三部分：危险性概述 危险性类别: 第3．2类 中闪点易燃液体 侵入途径: 吸入 食入 经皮吸收 健康危害: 吸入、摄入或经皮肤吸收对身体有害。其蒸气或烟雾对眼睛、皮肤、粘膜和呼吸道有刺激作用。 燃爆危险: 本品易燃，具刺激性。 第四部分：急救措施 皮肤接触: 脱去污染的衣着，用流动清水冲洗。 眼睛接触: 立即提起眼睑，用大量流动清水彻底冲洗。 吸入: 迅速脱离现场至空气新鲜处。保持呼吸道通畅。必要时进行人工呼吸。就医。 食入: 误服者给饮大量温水，催吐，就医。 第五部分：消防措施 危险特性: 遇明火、高热易燃。与氧化剂能发生强烈反应。若遇高热，容器内压增．大，有开裂和爆炸的危险。 有害燃烧产物: 一氧化碳、二氧化碳、氧化氮。 灭火方法及灭火剂: 雾状水、泡沫、二氧化碳、干粉、砂土。 消防员的个体防护: 消防人员须佩戴防毒面具、穿全身消防服 闪点(℃): 22 自燃温度(℃): 无资料 爆炸下限[%(V/V)]: 无资料 爆炸上限[%(V/V)]: 无资料 第六部分：泄漏应急处理 应急处理: 疏散泄漏污染区人员至安全区，禁止无关人员进入污染区，建议应急处理人员戴自给式呼吸器，穿一般消防防护服。在确保安全情况下堵漏。用沙土或其它不燃性吸附剂混合吸收，然后收集运至废物处理场所处置。也可以用大量水冲洗，经稀释的洗水放入废水系统。如大量泄漏，利用围堤收容，然后收集、转移、回收或无害处理后废弃。 第七部分：操作处置与储存 操作注意事项: 密闭操作，全面通风。操作人员必须经过专门培训，严格遵守操作规程。建议操作人员佩戴自吸过滤式防毒面具（半面罩），戴化学安全防护眼镜，穿防毒物渗透工作服，戴橡胶手套。远离火种、热源，工作场所严禁吸烟。使用防爆型的通风系统和设备。防止蒸气泄漏到工作场所空气中。避免与氧化剂、酸类、碱类接触。充装要控制流速，防止静电积聚。搬运时要轻装轻卸，防止包装及容器损坏。配备相应品种和数量的消防器材及泄漏应急处理设备。倒空的容器可能残留有害物。 储存注意事项: 储存于阴凉、通风的库房。远离火种、热源。库温不宜超过30℃。应与氧化剂、酸类、碱类分开存放，切忌混储。采用防爆型照明、通风设施。禁止使用易产生火花的机械设备和工具。储区应备有泄漏应急处理设备和合适的收容材料。 第八部分：接触控制/个体防护 最高容许浓度: 中国MAC：未制定标准苏联MAC：未制定标准美国TWA：未制定标准美国STEL：未制定标 工程控制: 生产过程密闭，全面通风。 呼吸系统防护: 空气中浓度较高时，应该佩带防毒口罩。 眼睛防护: 戴安全防护眼镜。 身体防护: 穿相应的防护服。 手防护: 戴防化学品手套。 其他防护: 工作现场禁止吸烟、进食和饮水。工作后，淋浴更衣。注意个人清洁卫生。 第九部分：理化特性 外观与性状: 无色液体，有氨味。 熔点(℃): -3．8 沸点(℃): 180～185 相对密度(水=1): 1．01 相对蒸气密度(空气=1): 无资料 饱和蒸气压(kPa): 无资料 闪点(℃): 22 引燃温度(℃): 无资料 爆炸上限%(V/V): 无资料 爆炸下限%(V/V): 无资料 分子式: C2H5NO 分子量: 59.07 溶解性: 与水混溶，可混溶于乙醇。 主要用途: 用作溶剂及用于有机合成。 第十部分：稳定性和反应活性 稳定性: 在常温常压下 稳定 禁配物: 强氧化剂、酸类、碱类。 聚合危害: 不能出现 分解产物: 一氧化碳、二氧化碳、氧化氮。 第十一部分：毒理学资料 急性毒性: LD50：4000mg／kg(大鼠经口) LC50： 第十三部分：废弃处置 废弃处置方法: 处置前应参阅国家和地方有关法规。建议用焚烧法处置。焚烧炉排出的氮氧化物通过洗涤器除去。 第十四部分：运输信息 包装类别: Ⅱ 运输注意事项: 储存于阴凉、通风仓间内。远离火种、热源。仓温不宜超过30℃。防止阳光直射。包装要求密封，不可与空气接触。应与氧化剂分开存放。储存间内的照明、通风等设施应采用防爆型，开关设在仓外。配备相应品种和数量的消 第十五部分：法规信息 国内化学品安全管理法规: 化学危险物品安全管理条例 (1987年2月17日国务院发布)，化学危险物品安全管理条例实施细则 (化劳发[1992] 677号)，工作场所安全使用化学品规定 ([1996]劳部发423号)等法规，针对化学危险品的安全使用、生产、储存、运输、装卸等方面均作了相应规定。 第十六部分：其他信息 参考文献: 1.周国泰，化学危险品安全技术全书，化学工业出版社，1997 2.国家环保局有毒化学品管理办公室、北京化工研究院合编，化学品毒性法规环境数据手册，中国环境科学出版社.1992 3.Canadian Centre for Occupational Health and Safety,CHEMINFO Database.1998 4.Canadian Centre for Occupational Health and Safety, RTECS Database, 1989 填表时间: 年月日 其他信息: 1 MSDS修改日期: 年月日

毒性和生态

毒理学数据: 大鼠经口LD50为2700mg/kg。小鼠静脉注射LC50为4420mg/kg。小鼠腹腔注射LC50为707mg/kg。 CHEMICAL IDENTIFICATION RTECS NUMBER : LQ3000000 CHEMICAL NAME : Formamide, N-methyl- CAS REGISTRY NUMBER : 123-39-7 BEILSTEIN REFERENCE NO. : 1098352 LAST UPDATED : 199712 DATA ITEMS CITED : 40 MOLECULAR FORMULA : C2-H5-N-O MOLECULAR WEIGHT : 59.08 WISWESSER LINE NOTATION : VHM1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : Administration into the eye SPECIES OBSERVED : Rodent - rabbit REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 39,129,1977 ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 4 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 4,219,1962 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 3500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 4,219,1962 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >2500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : APEPA2 Naunyn-Schmiedebergs Archiv fuer Pharmakologie und Experimentelle Pathologie. (Berlin, Ger.) V.254-263, 1966-69. For publisher information, see NSAPCC. Volume(issue)/page/year: 257,296,1967 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2400 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - corneal damage Behavioral - somnolence (general depressed activity) Musculoskeletal - other changes REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 57(2),30,1992 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2600 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 34,173,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 802 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3100 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - weight loss or decreased weight gain Nutritional and Gross Metabolic - body temperature decrease REFERENCE : DABBBA Dissertation Abstracts International, B: The Sciences and Engineering. (University Microfilms International, 300 N. Zeeb Rd., Ann Arbor, MI 48106) V.30- 1969- Volume(issue)/page/year: 40,549,1979 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1580 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 34,173,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2700 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 34,173,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1175 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - corneal damage Behavioral - somnolence (general depressed activity) Musculoskeletal - other changes REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 57(2),30,1992 TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : >568 mg/kg TOXIC EFFECTS : Behavioral - food intake (animal) Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB82-232158 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 465 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - corneal damage Behavioral - somnolence (general depressed activity) Musculoskeletal - other changes REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 57(2),30,1992 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 5460 ug/kg/26W-I TOXIC EFFECTS : Lungs, Thorax, or Respiration - changes in lung weight Blood - changes in leukocyte (WBC) count Nutritional and Gross Metabolic - changes in chlorine REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 57(2),30,1992 TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 400 ppm/6H/2W-I TOXIC EFFECTS : Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases REFERENCE : FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 14,810,1990 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 5603 mg/kg/5D-I TOXIC EFFECTS : Liver - hepatitis (hepatocellular necrosis), zonal Endocrine - other changes Related to Chronic Data - death REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB82-232158 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 4 gm/kg/10D-I TOXIC EFFECTS : Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases REFERENCE : TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 34,173,1985 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 662 mg/kg/5D-I TOXIC EFFECTS : Liver - hepatitis (hepatocellular necrosis), zonal Endocrine - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB82-232158 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 1 gm/kg SEX/DURATION : female 7 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - homeostasis Reproductive - Specific Developmental Abnormalities - other developmental abnormalities REFERENCE : 85DJA5 "Malformations Congenitales des Mammiferes," Tuchmann-Duplessis, H., Paris, Masson et Cie, 1971 Volume(issue)/page/year: -,95,1971 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 750 mg/kg SEX/DURATION : female 6-15 day(s) after conception TOXIC EFFECTS : Reproductive - Maternal Effects - other effects Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) REFERENCE : FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 27,239,1995 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 750 mg/kg SEX/DURATION : female 6-15 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 27,239,1995 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Administration onto the skin DOSE : 1200 mg/kg SEX/DURATION : female 12-13 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - body wall REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 41,35,1977 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Administration onto the skin DOSE : 400 mg/kg SEX/DURATION : female 12-13 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - Central Nervous System REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 41,35,1977 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Administration onto the skin DOSE : 600 mg/kg SEX/DURATION : female 9 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetal death REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 41,35,1977 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal DOSE : 700 mg/kg SEX/DURATION : female 7-13 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - other developmental abnormalities REFERENCE : 85DJA5 "Malformations Congenitales des Mammiferes," Tuchmann-Duplessis, H., Paris, Masson et Cie, 1971 Volume(issue)/page/year: -,95,1971 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 500 mg/kg SEX/DURATION : female 10 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - other developmental abnormalities REFERENCE : APEPA2 Naunyn-Schmiedebergs Archiv fuer Pharmakologie und Experimentelle Pathologie. (Berlin, Ger.) V.254-263, 1966-69. For publisher information, see NSAPCC. Volume(issue)/page/year: 257,296,1967 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 200 mg/kg SEX/DURATION : female 11 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 17,610,1967 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 400 mg/kg SEX/DURATION : female 11 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 17,610,1967 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Administration onto the skin DOSE : 400 mg/kg SEX/DURATION : female 11 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 17,610,1967 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Administration onto the skin DOSE : 800 mg/kg SEX/DURATION : female 11 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 17,610,1967 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 70 mg/kg SEX/DURATION : female 11 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - other developmental abnormalities REFERENCE : DABBBA Dissertation Abstracts International, B: The Sciences and Engineering. (University Microfilms International, 300 N. Zeeb Rd., Ann Arbor, MI 48106) V.30- 1969- Volume(issue)/page/year: 40,549,1979 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 650 mg/kg SEX/DURATION : female 6-18 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 30,1557,1980 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 650 mg/kg SEX/DURATION : female 6-18 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 30,1557,1980 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 650 mg/kg SEX/DURATION : female 6-18 day(s) after conception TOXIC EFFECTS : Reproductive - Maternal Effects - other effects Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - Central Nervous System REFERENCE : FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 27,239,1995 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 650 mg/kg SEX/DURATION : female 6-18 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - gastrointestinal system REFERENCE : FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 27,239,1995 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Administration onto the skin DOSE : 1800 mg/kg SEX/DURATION : female 8-16 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetal death REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 41,35,1977

安全

• 符号: GHS07, GHS08
• 信号词: Danger
• 危害声明: H312-H360
• 警示性声明: P201-P280-P308 + P313
• 个人防护装备: Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
• 危害码 (欧洲): T:Toxic;
• 风险声明 (欧洲): R21;R61
• 安全声明 (欧洲): S53-S45
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 1
• RTECS号: LQ3000000
• 包装等级: II
• 海关编码: 2924199090

合成路线

上下游产品

上游产品  10
107-31-3 74-89-5 10352-28-0 74-88-4
18952-41-5 201230-82-2 593-51-1 64-18-6
75-50-3 50-00-0
下游产品  10
1117-72-2 64-18-6 74-89-5 74-90-8
108-89-4 107427-71-4 5470-34-8 3717-38-2
937602-15-8 4597-87-9

制备

1.甲胺法由甲胺与一氧化碳反应制得。

2.甲酸甲酯法由甲酸甲酯与甲胺反应而得。

3.由甲酸乙酯和甲胺反应而得。将甲酸乙酯加入反应器中，在冷却下加入甲胺水溶液，于40℃回流反应。然后放置3d，减压回收乙醇得到粗品。再经减压蒸馏而得成品。

精制方法：实验室常用碱处理脱水或利用苯水共沸蒸馏脱水后精馏的方法精制。也可以用分子筛处理后精馏精制。

4.在冷却下将氯化钙加到甲酸与乙醇的混合液中，回流12～13h，得粗品。粗品用碳酸钠中和过滤分馏。反应如下：

在冷却下，边搅拌边将甲胺水溶液加到甲酸乙酯中，控制温度40℃左右，充分静置。减压回收醇，将粗品进行减压提纯，即得成品。反应如下：

海关

海关编码	2924199090
中文概述	2924199090. 其他无环酰胺（包括无环氨基甲酸酯)(包括其衍生物及盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 包装
Summary	2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%