319-89-1

• 常用中文名：四羟基苯醌
• 常用英文名：Tetrahydroxyquinone
• CAS号：319-89-1
• 分子式：C₆H₄O₆
• 分子量：172.09200
• 相关类别： 有机原料 醌类化合物
• 发布时间：2018-04-20 08:00:00
• 更新时间：2024-01-03 19:17:12
• Tetrahydroxyquinone是一种最有名的原始抗白内障药物, 也是高度氧化还原的活性分子, 能与半醌自由基参与氧化还原循环, 导致活性氧 (ROS) 的形成。

名称

• 中文名: 四羟基苯醌
• 英文名: Tetrahydroxyquinone
• 中文别名: 2,3,5,6-四羟基-2,5-环已二烯-1,4-二酮; 四羟基-1,4-苯二酮; 四氧醌; 四氢-P-苯醌
• 英文别名: TETROQUINONE; Terasin; 2,3,5,6-tetrahydroxybenzoquinone; TETRAHYDROXY-1,4-QUINONE; TETRAHYDROXY BENZOQUINONE; Kelox; 2,3,5,6-tetrahydroxo-1,4-benzoquinone; EINECS 206-275-5; Tetroquinone monohydrate; Tetrahydroxy-p-quinone; HPEK-1; tetrahydroxy-p-benzoquinone; MFCD00001597; 2,3,5,6-TETRAHYDROXY-1,4-BENZOQUINONE; tetrahydroxy-1,4-benzoquinone

物化性质

• 密度: 0.79
• 沸点: 148 °C / 15mmHg
• 熔点: 300ºC
• 分子式: C₆H₄O₆
• 分子量: 172.09200
• 精确质量: 172.00100
• PSA: 115.06000
• 外观性状: 固体。
• 折射率: 2.023
• 储存条件: 室温，干燥
• 稳定性: Stable. Incompatible with strong oxidizing agents, strong bases.
• 分子结构:

  1、 摩尔折射率：33.48

  2、 摩尔体积（m³/mol）：65.9

  3、 等张比容（90.2K）：279.3

  4、 表面张力（dyne/cm）：321.9

  5、 极化率（10 ^-24cm ³）：13.27

• 计算化学:

  1.疏水参数计算参考值（XlogP）:-0.6

  2.氢键供体数量:4

  3.氢键受体数量:6

  4.可旋转化学键数量:0

  5.互变异构体数量:7

  6.拓扑分子极性表面积115

  7.重原子数量:12

  8.表面电荷:0

  9.复杂度:272

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

• 更多:

  一、物性数据

  性状：不可用

  密度（g/mL,25/4℃）：不可用

  相对蒸汽密度（g/mL,空气=1）：不可用

  熔点（ºC）：不可用

  沸点（ºC,常压）：不可用

  沸点（ºC,5.2kPa）：不可用

  折射率：不可用

  闪点（ºC）：不可用

  比旋光度（º）：不可用

  自燃点或引燃温度（ºC）：不可用

  蒸气压（kPa,25ºC）：不可用

  饱和蒸气压（kPa,60ºC）：不可用

  燃烧热（KJ/mol）：不可用

  临界温度（ºC）：不可用

  临界压力（KPa）：不可用

  油水（辛醇/水）分配系数的对数值：不可用

  爆炸上限（%,V/V）：不可用

  爆炸下限（%,V/V）：不可用

  溶解性：不可用

生物活性

• 描述: Tetrahydroxyquinone是一种最有名的原始抗白内障药物, 也是高度氧化还原的活性分子, 能与半醌自由基参与氧化还原循环, 导致活性氧 (ROS) 的形成。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 癌症

MSDS

Name: Tetrahydroxy-P-Quinone Monohydrate 99% (Titr.) Material Safety Data Sheet Synonym: Tetrahydroxy-P-Benzoquinone; Tetroquinon CAS: 319-89-1 Section 1 - Chemical Product MSDS Name:Tetrahydroxy-P-Quinone Monohydrate 99% (Titr.) Material Safety Data Sheet Synonym:Tetrahydroxy-P-Benzoquinone; Tetroquinon Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 319-89-1 Tetrahydroxyquinone 99 206-275-5 Hazard Symbols: None Listed. Risk Phrases: None Listed. Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW The toxicological properties of this material have not been fully investigated. Potential Health Effects Eye: May cause eye irritation. The toxicological properties of this material have not been fully investigated. Skin: May cause skin irritation. The toxicological properties of this material have not been fully investigated. Ingestion: May cause gastrointestinal irritation with nausea, vomiting and diarrhea. The toxicological properties of this substance have not been fully investigated. Inhalation: Dust is irritating to the respiratory tract. May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated. Chronic: No information found. Section 4 - FIRST AID MEASURES Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid if irritation develops or persists. Wash clothing before reuse. Flush skin with plenty of soap and water. Ingestion: Never give anything by mouth to an unconscious person. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Get medical aid if irritation or symptoms occur. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid if cough or other symptoms appear. Notes to Physician: Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing Media: Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions. Provide ventilation. Section 7 - HANDLING and STORAGE Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Storage: Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 319-89-1: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Solid Color: black Odor: penetrating odor pH: Not available. Vapor Pressure: Negligible. Viscosity: Not applicable. Boiling Point: Not available. Freezing/Melting Point: 300 deg C Autoignition Temperature: Not applicable. Flash Point: Not applicable. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Not available. Solubility in water: Slightly soluble in cold water Specific Gravity/Density: Not available. Molecular Formula: C6H4O6.H2O Molecular Weight: 172.0244 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: Incompatible materials, dust generation, excess heat. Incompatibilities with Other Materials: Oxidizing agents. Hazardous Decomposition Products: Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide. Hazardous Polymerization: Has not been reported. Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 319-89-1 unlisted. LD50/LC50: Not available. Carcinogenicity: Tetrahydroxyquinone - Not listed by ACGIH, IARC, or NTP. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Not regulated as a hazardous material. IMO Not regulated as a hazardous material. RID/ADR Not regulated as a hazardous material. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: Not available. Risk Phrases: Safety Phrases: S 28A After contact with skin, wash immediately with plenty of water. S 37 Wear suitable gloves. S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). WGK (Water Danger/Protection) CAS# 319-89-1: No information available. Canada CAS# 319-89-1 is listed on Canada's DSL List. CAS# 319-89-1 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 319-89-1 is listed on the TSCA inventory. SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

毒理学数据: 二、毒理学数据： 急性毒性：不可用。 生态学数据: 三、生态学数据： 1、其它有害作用：该物质对环境可能有危害，对水体应给予特别注意。

安全

• 危害码 (欧洲): Xi: Irritant;
• 风险声明 (欧洲): R36/37/38
• 安全声明 (欧洲): S26-S36
• WGK德国: 3
• 海关编码: 2914690090

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海关

海关编码	2914690090
中文概述	2914690090 其他醌. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:5.5% 普通关税:30.0%
Summary	2914690090 other quinones。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%