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88192-20-5

88192-20-5结构式
88192-20-5结构式
  • 常用中文名:4-叠氮基-1-丁胺
  • 常用英文名:4-Azidobutylamine
  • CAS号:88192-20-5
  • 分子式:C4H10N4
  • 分子量:114.14900
  • 相关类别: 信号通路 蛋白裂解靶向嵌合体 PROTAC Linker
  • 发布时间:2018-03-23 08:00:00
  • 更新时间:2024-01-02 19:06:07
  • 4-Azidobutylamine 是一种 PROTAC 连接桥,属于 alkyl chain 类。4-Azidobutylamine 可用于合成一系列 PROTAC 分子。PROTAC 分子含有两个通过连接桥连接的不同配体; 一种是 E3 泛素连接酶配体,另一种是靶蛋白配体。PROTAC 利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白。

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中文名 4-叠氮基-1-丁胺
英文名 4-Azidobutan-1-amine
英文别名 6-azidobutylamine
4-Azido-1-butanamine
1-amino-4-azidobutane
4-azido-1-butylamine
1-azido-4-aminobutane
4-azido-butylamine
1-Butanamine,4-azido
描述 4-Azidobutylamine 是一种 PROTAC 连接桥,属于 alkyl chain 类。4-Azidobutylamine 可用于合成一系列 PROTAC 分子。PROTAC 分子含有两个通过连接桥连接的不同配体; 一种是 E3 泛素连接酶配体,另一种是靶蛋白配体。PROTAC 利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白。
相关类别
参考文献

[1]. Schiedel M, et al. Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals). J Med Chem. 2018 Jan 25;61(2):482-491.

[2]. Schiedel M, et al. Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals). J Med Chem. 2018 Jan 25;61(2):482-491.

分子式 C4H10N4
分子量 114.14900
精确质量 114.09100
PSA 75.77000
LogP 1.18866
Material Safety Data Sheet

Section1. Identification of the substance
Product Name: 4-Azidobutan-1-amine
Synonyms:

Section2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

Section3. Composition/information on ingredients.
Ingredient name:4-Azidobutan-1-amine
CAS number:88192-20-5

Section4. First aid measures
Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

Section5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

Section6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution:Wear approved mask/respirator
Hand precaution:Wear suitable gloves/gauntlets
Skin protection:Wear suitable protective clothing
Eye protection:Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

Section7. Handling and storage
Handling:This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Storage:Store in closed vessels, refrigerated.

Section8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

Section9. Physical and chemical properties
Appearance:Not specified
Boiling point:No data
Melting point:No data
Flash point:No data
Density:No data
Molecular formula: C4H10N4
Molecular weight: 114.2

Section10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides.

Section11. Toxicological information
No data.

Section12. Ecological information
No data.

Section13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

Section14. Transportation information
Non-harzardous for air and ground transportation.

Section15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.


SECTION 16 - ADDITIONAL INFORMATION
N/A
海关编码 2929909090

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文献:Srinivasan, Rajavel; Tan, Lay Pheng; Wu, Hao; Yang, Peng-Yu; Kalesh, Karunakaran A.; Yao, Shao Q. Organic and Biomolecular Chemistry, 2009 , vol. 7, # 9 p. 1821 - 1828

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文献:NATIONAL TSING HUA UNIVERSITY Patent: US2011/306668 A1, 2011 ; Location in patent: Page/Page column 23-24 ;

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文献:Su, Yuan-Hsiao; Chiang, Li-Wu; Jeng, Kee-Ching; Huang, Ho-Lien; Chen, Jenn-Tzong; Lin, Wuu-Jyh; Huang, Chia-Wen; Yu, Chung-Shan Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 5 p. 1320 - 1324

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文献:Meiji Seika Kaisha, Ltd. Patent: EP1661904 A1, 2006 ; Location in patent: Page/Page column 40 ;

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文献:Wieland, Marcel; Mieusset, Jean-Luc; Brinker, Udo H. Tetrahedron Letters, 2012 , vol. 53, # 33 p. 4351 - 4353

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文献:Khoukhi, Mostafa; Vaultier, Michel; Benalil, Aziza; Carboni, Bertrand Synthesis, 1996 , # 4 p. 483 - 487

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文献:Bandyopadhyay, Sabyasachi; Mukherjee, Sohini; Dey, Abhishek RSC Advances, 2013 , vol. 3, # 38 p. 17174 - 17187
海关编码 2929909090
中文概述 2929909090 其他含氮基化合物. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:30.0%
申报要素 品名, 成分含量, 用途
Summary 2929909090 other compounds with other nitrogen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%