246847-98-3

• 常用中文名：2-氨基-3-氟-5-氯吡啶
• 常用英文名：5-Chloro-3-fluoro-2-pyridinamine
• CAS号：246847-98-3
• 分子式：C₅H₄ClFN₂
• 分子量：146.550
• 相关类别： 医药中间体 杂环化合物 吡啶类化合物 氯吡啶
• 发布时间：2018-08-29 10:49:34
• 更新时间：2024-01-02 08:12:36
• 下载msds

名称

• 中文名: 2-氨基-3-氟-5-氯吡啶
• 英文名: 2-Amino-5-chloro-3-fluoropyridine
• 中文别名: 2-氨基-5-氯-3-氟砒啶; 2-氨基-5-氯-3-氟吡啶; 2-氨基-5-氯-3-氟吡啶
• 英文别名: 2-Pyridinamine, 5-chloro-3-fluoro-; 2-Amino-5-Chloro-3-Fluoropyridine; 5-Chloro-3-fluoropyridin-2-amine; 5-Chloro-3-fluoro-2-pyridinamine

物化性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 195.9±35.0 °C at 760 mmHg
• 熔点: 95-97℃
• 分子式: C₅H₄ClFN₂
• 分子量: 146.550
• 闪点: 72.3±25.9 °C
• 精确质量: 146.004700
• PSA: 38.91000
• LogP: 1.57
• 蒸汽压: 0.4±0.4 mmHg at 25°C
• 折射率: 1.576
• 储存条件: 2-8°C

MSDS

Material Safety Data Sheet Section1. Identification of the substance Product Name: 2-Amino-5-chloro-3-fluoropyridine Synonyms:5-Chloro-3-fluoropyridin-2-amine Section2. Hazards identification Harmful by inhalation, in contact with skin, and if swallowed. H301:Toxic if swallowed H311:Toxic in contact with skin H319:Causes serious eye irritation Toxic if inhaled H331: H400:Very toxic to aquatic life P261:Avoid breathing dust/fume/gas/mist/vapours/spray P273:Avoid release to the environment P280:Wear protective gloves/protective clothing/eye protection/face protection P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing P311:Call a POISON CENTER or doctor/physician Section3. Composition/information on ingredients. Ingredient name:2-Amino-5-chloro-3-fluoropyridine CAS number:246847-98-3 Section4. First aid measures Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing contaminated clothing and shoes. If irritation persists, seek medical attention. Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate Eye contact: flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical attention. Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention. Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention. Section5. Fire fighting measures In the event of a fire involving this material, alone or in combination with other materials, use dry powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus should be worn. Section6. Accidental release measures Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national standards. Respiratory precaution:Wear approved mask/respirator Hand precaution:Wear suitable gloves/gauntlets Skin protection:Wear suitable protective clothing Eye protection:Wear suitable eye protection Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container for disposal. See section 12. Environmental precautions: Do not allow material to enter drains or water courses. Section7. Handling and storage Handling:This product should be handled only by, or under the close supervision of, those properly qualified in the handling and use of potentially hazardous chemicals, who should take into account the fire, health and chemical hazard data given on this sheet. Storage:Store in closed vessels. Section8. Exposure Controls / Personal protection Engineering Controls: Use only in a chemical fume hood. Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles. General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse. Section9. Physical and chemical properties Not specified Appearance: Boiling point:No data Melting point:No data Flash point:No data Density:No data Molecular formula: C5H4ClFN2 Molecular weight: 146.6 Section10. Stability and reactivity Conditions to avoid: Heat, flames and sparks. Materials to avoid: Oxidizing agents. Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen chloride, hydrogen fluoride. Section11. Toxicological information No data. Section12. Ecological information No data. Section13. Disposal consideration Arrange disposal as special waste, by licensed disposal company, in consultation with local waste disposal authority, in accordance with national and regional regulations. Section14. Transportation information UN Number:UN2811Class: 6.1Packing group: III Proper shipping name: TOXIC SOLIDS, ORGANIC, N.O.S. (2-Amino-5-chloro-3-fluoropyridine) Section15. Regulatory information No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302, or have known CAS numbers that exceed the threshold reporting levels established by SARA Title III, Section 313. SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 符号: GHS06, GHS09
• 信号词: Danger
• 危害声明: H301-H311-H319-H331-H400
• 警示性声明: P261-P273-P280-P301 + P310-P305 + P351 + P338-P311
• 危害码 (欧洲): T,Xi
• 风险声明 (欧洲): 23/24/25-50
• 安全声明 (欧洲): 36/37-38-45-61-63
• 危险品运输编码: UN 2811 6.1 / PGIII
• 海关编码: 2933399090

合成路线

248255-70-1 ~% 246847-98-3

文献：US2006/47124 A1, ; Page/Page column 4 ; US 20060047124 A1

89402-43-7 ~76% 246847-98-3

文献：US2008/242695 A1, ; Page/Page column 34 ;

上下游产品

上游产品  2
248255-70-1 89402-43-7
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海关

海关编码	2933399090
中文概述	2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%