1185-57-5

• 常用中文名：柠檬酸铁铵
• 常用英文名：Ferric ammonium citrate
• CAS号：1185-57-5
• 分子式：C₆H₈FeNO₇
• 分子量：261.975
• 相关类别： 原料药 血液系统用药 抗贫血药
• 发布时间：2018-06-18 11:00:23
• 更新时间：2024-01-02 18:04:41
• 柠檬酸铁铵(III)(柠檬酸铁铵),一种非转铁蛋白结合铁的生理形式,诱导细胞内铁超载,导致铁下垂[1]。柠檬酸铁铵(III)可以提高蛋白质产量[2]。

名称

• 中文名: 柠檬酸铁铵
• 英文名: Ammonium ferric citrate
• 中文别名: 柠檬酸铁(III)铵; 枸橼酸铁铵; 2-羟基-1,2,3-丙三羧酸铁(III)铵盐; 柠檬酸铁胺
• 英文别名: Ferric; EINECS 214-686-6; Iron(3+) 2-hydroxy-1,2,3-propanetricarboxylate ammoniate (1:1:1); Ferricammoniumcitrae; 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, ammonium iron(3+) salt (1:1:1); MFCD00013099; Ammonium iron(III) citrate; Ammonium Ferric Citrate; Ammoniumironcitrate; IRON AMMONIUM CITRATE; Citric acid iron ammonium; Amonium Iron(III) Citrate Supplement; Ironandammoniumcit-rate; AmmoniumFerricCitrateUsp

物化性质

• 密度: 1.8 g/cm3 (20ºC)
• 沸点: 197ºC
• 分子式: C₆H₈FeNO₇
• 分子量: 261.975
• 精确质量: 261.965027
• PSA: 102.37000
• 外观性状: 淡黄色棕色至红色固体,带有一种微弱氨气味
• 储存条件:

  保持贮藏器密封、储存在阴凉、干燥的地方，确保工作间有良好的通风或排气装置

• 稳定性:

  如果遵照规格使用和储存则不会分解，未有已知危险反应，避免氧化物

  本品是由铁、铵和柠檬酸组成的结构不明的络盐。应制造条件不同，具有多种组成。棕色、绿色或酱红色透明薄片或颗粒，或棕黄色粉末。无臭或稍带氨臭和温和的铁金属味。空气中易潮解，易生霉。极易溶于水（1g/0.5mL），水溶液近中性，不溶于乙醇和乙醚。5%的水溶液ｐＨ值约为5.0～8.0。
• 水溶解性: 1200 g/L (20 ºC)
• 分子结构:

  1、摩尔折射率：无可用的

  2、摩尔体积（cm³/mol）：无可用的

  3、等张比容（90.2K）：无可用的

  4、表面张力（dyne/cm）：无可用的

  5、介电常数：无可用的

  6、极化率（10^-24cm³）：无可用的

  7、单一同位素质量：261.965019 Da

  8、标称质量：262 Da

  9、平均质量：261.9752 Da

• 计算化学:

  1、 氢键供体数量：2

  2、 氢键受体数量：8

  3、 可旋转化学键数量：2

  <SPAN lang=EN-US style="FONT-SIZE: 9pt; FONT-FAMILY: Arial; mso-font-kerning: 0pt; mso-fareast-font-family

• 更多:

  1. 性状：红棕色颗粒或石榴红透明鳞片或棕黄色粉末。无气味或微有氨臭。有碱铁味。

  2. 密度（g/mL,25/4℃）： 未确定

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC）：未确定

  5. 沸点（ºC,常压）：未确定

  6. 沸点（ºC,5.2kPa）：未确定

  7. 折射率：未确定

  8. 闪点（ºC）：未确定

  9. 比旋光度（º）：未确定

  10. 自燃点或引燃温度（ºC）：未确定

  11. 蒸气压（kPa,25ºC）：未确定

  12. 饱和蒸气压（kPa,60ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性：极易潮解，露光还原为亚铁盐。易溶于水，几乎不溶于乙醇。

生物活性

• 描述: 柠檬酸铁铵(III)(柠檬酸铁铵),一种非转铁蛋白结合铁的生理形式,诱导细胞内铁超载,导致铁下垂[1]。柠檬酸铁铵(III)可以提高蛋白质产量[2]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞凋亡 >> Ferroptosis
• 体外研究: 柠檬酸铁铵(III)(柠檬酸铁铵；1,5,10,15毫米；在HT1080细胞中,用5 mM诱导24小时的细胞死亡。AML12细胞对柠檬酸铁铵(III)具有高度抗性,因为它们维持约80%的细胞活力。柠檬酸铁铵(III)可通过特异性转运体主动转运至细胞[1]。柠檬酸铁铵(III)(6,12,18 mg/L)在含有12 mg/L和18 mg/L的BG-11培养基中对小球藻FSP-E(CV)具有较高的生物量[2]。
• 参考文献:

  [1]. Shenglin Fang, et al. Effects of intracellular iron overload on cell death and identification of potent cell death inhibitors. Biochem Biophys Res Commun. 2018 Sep 3;503(1):297-303.

  [2]. Yu-Cheng Lai, et al. Towards protein production and application by using Chlorella species as circular economy. Bioresour Technol. 2019 Oct;289:121625.

MSDS

Name: Ammonium Iron(III)-Citrate Material Safety Data Sheet Synonym: Ferric Ammonium Citrate, Citric Acid Ammonium Iron (3+) Salt CAS: 1185-57-5 Section 1 - Chemical Product MSDS Name:Ammonium Iron(III)-Citrate Material Safety Data Sheet Synonym:Ferric Ammonium Citrate, Citric Acid Ammonium Iron (3+) Salt Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 1185-57-5 FERRIC AMMONIUM CITRATE 100 214-686-6 Hazard Symbols: None Listed. Risk Phrases: None Listed. Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Not available. Potential Health Effects Eye: May cause irritation, pain, blurred vision, and possible burns. Skin: May cause skin irritation. Ingestion: May cause irritation of the digestive tract. Inorganic iron compounds may cause gastrointestinal irritation and damage, vomiting, pulmonary edema, convulsions, rapid heart beat and low blood pressure. Ingestion of iron compounds may cause hemorrhage and necrosis of the stomach with shock, severe diarrhea, and possible coma. Inhalation: May cause respiratory tract irritation. Chronic: No information found. Section 4 - FIRST AID MEASURES Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Skin: Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Ingestion: If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately. Inhalation: Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Notes to Physician: Antidote: The use of Deferoxamine as a chelating agent should be determined only by qualified medical personnel. Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or appropriate foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation. Section 7 - HANDLING and STORAGE Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with skin and eyes. Avoid ingestion and inhalation. Storage: Store in a cool, dry place. Do not store in direct sunlight. Keep containers tightly closed. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Use adequate ventilation to keep airborne concentrations low. Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Solid Appearance: yellow to green Odor: None reported pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Decomposes. Freezing/Melting Point: Decomposes. Autoignition Temperature: Not applicable. Flash Point: Not applicable. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Not available. Solubility in water: Soluble. Specific Gravity/Density: 1.8 @ 20C Molecular Formula: Mixture Molecular Weight: 0 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: Incompatible materials, light, excess heat. Incompatibilities with Other Materials: Strong oxidizing agents - light. Hazardous Decomposition Products: Ammonia. Hazardous Polymerization: Has not been reported. Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 1185-57-5: GE7540000 LD50/LC50: Not available. Carcinogenicity: FERRIC AMMONIUM CITRATE - Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA. See actual entry in RTECS for complete information. Section 12 - ECOLOGICAL INFORMATION Other No information available. Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Not regulated as a hazardous material. IMO Not regulated as a hazardous material. RID/ADR Not regulated as a hazardous material. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: Not available. Risk Phrases: Safety Phrases: S 24/25 Avoid contact with skin and eyes. WGK (Water Danger/Protection) CAS# 1185-57-5: No information available. United Kingdom Occupational Exposure Limits Canada CAS# 1185-57-5 is listed on Canada's DSL List. CAS# 1185-57-5 is not listed on Canada's Ingredient Disclosure List. Exposure Limits CAS# 1185-57-5: OEL-DENMARK:TWA 1 mg(Fe)/m3 JANUARY 1993 OEL-FINLAND:TWA 1 mg(Fe)/m3 JANUARY 1993 OEL-THE NETHERLANDS:TWA 1 mg(Fe)/m3 JANUARY 1993 OEL-SWITZERLAND:TWA 1 mg(Fe)/m3 JANUARY 1993 OEL-UNITED KINGDOM:TWA 1 mg(Fe)/m3;STEL 2 mg(Fe)/m3 JANUARY 1993 US FEDERAL TSCA CAS# 1185-57-5 is listed on the TSCA inventory. SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

生态学数据: 对水是稍微有危害的不要让未稀释或大量的产品接触地下水、水道或者污水系统，若无政府许可，勿将材料排入周围环境 CHEMICAL IDENTIFICATION RTECS NUMBER : GE7540000 CHEMICAL NAME : Citric acid, ammonium iron(3+) salt CAS REGISTRY NUMBER : 1185-57-5 LAST UPDATED : 199712 DATA ITEMS CITED : 9 MOLECULAR FORMULA : C6-H8-O7.xFe.xH4-N

安全

• 符号: GHS07
• 信号词: Warning
• 危害声明: H315-H319-H335
• 警示性声明: P261-P305 + P351 + P338
• 个人防护装备: dust mask type N95 (US);Eyeshields;Gloves
• 危害码 (欧洲): Xi:Irritant
• 风险声明 (欧洲): R36/37/38
• 安全声明 (欧洲): S26-S36
• 危险品运输编码: UN 9118
• WGK德国: 3
• RTECS号: GE7540000
• 海关编码: 2918150000

制备

1.在硫酸铁溶液中加入氨水，生成氢氧化铁沉淀；过滤、水洗至无硫酸反应，然后加入柠檬酸，并加热至60℃，使沉淀全部溶解；再用氨水中和，浓缩至糖浆状，并涂布于玻璃板上，经微温干燥后剥离得小片状成品。
Fe2(SO4)3+6NH3+6H2O→3(NH4)2SO4+2Fe(OH)3↓
2C6H8O7+3NH4OH+Fe(OH)3→(C6H5O7)2Fe(NH4)3+6H2O
也可以硫酸亚铁为原料，将28g FeSO4·7H2O溶于4rnL水中，加入98%的浓硫酸3 rnL，再滴加5mL 36%的双氧水，升温至83℃，搅拌0.5h，用铁氰化钾检验显蓝色为反应终点；然后加入100mL蒸馏水，在80℃下搅拌加入40%的NaOH，使溶液呈碱性，将沉淀抽滤，用热水洗至无硫酸根为止。将制得的Fe(OH)3加入溶有14g柠檬酸的100mL水的溶液，在95℃下恒温搅拌1h；然后冷却至50℃，再加入适量的氨水，冷却至室温，静置澄清，上层清液蒸发浓缩至膏状，在60～80℃下烘干即得产品，收率91%。

2.在由硫酸亚铁和氨水制造的氢氧化铁中添加适量的柠檬酸溶液，将其浓缩所得的浆料涂敷于玻璃板干燥后，从玻璃板上剥离而制得。

3.将氢氧化铁溶于柠檬酸，用氨水中和，于60℃以下蒸发而得.

海关

海关编码	2918150000
中文概述	2918150000. 柠檬酸盐和柠檬酸酯. 增值税率:17.0%. 退税率:13.0%. 监管条件:4ABxy(出口许可证,入境货物通关单,出境货物通关单出口许可证(加工贸易),出口许可证(边境小额贸易)). 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途
监管条件	4.出口许可证 A.入境货物通关单 B.出境货物通关单 x.出口许可证(加工贸易) y.出口许可证(边境小额贸易)
检验检疫	R.进口食品卫生监督检验 S.出口食品卫生监督检验 N.出口商品检验
Summary	2918150000. other salts and esters of citric acid. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:4ABXY(export license,certificate of inspection for goods inward,certificate of inspection for goods outwardexport license(processing trade),export license(border small volume trade)). MFN tariff:6.5%. General tariff:30.0%