38129-37-2

• 常用中文名：二环霉素
• 常用英文名：Bicyclomycin
• CAS号：38129-37-2
• 分子式：C₁₂H₁₈N₂O₇
• 分子量：302.28
• 相关类别： 信号通路 抗感染 细菌
• 发布时间：2018-06-17 20:19:42
• 更新时间：2024-01-02 18:04:29
• Bicyclomycin 是一种 antibiotic。Bicyclomycin 对除了 Proteus 和Pseudomonas aeruginosa 以外的革兰氏阴性菌均有抗菌 (anti-Bacterial) 活性。

名称

• 中文名: 二环霉素
• 英文名: bicozamycin
• 英文别名: antibiotic WS-4545; bicyclomycin; WS-4545; (1S)-6-hydroxy-5-methylene-1-((1S,2S)-1,2,3-trihydroxy-2-methyl-propyl)-2-oxa-7,9-diaza-bicyclo[4.2.2]decane-8,10-dione; BicozaMycin benzoate

物化性质

• 密度: 1.57g/cm3
• 沸点: 786.6ºC at 760 mmHg
• 分子式: C₁₂H₁₈N₂O₇
• 分子量: 302.28
• 闪点: 429.5ºC
• 精确质量: 302.11100
• PSA: 148.35000
• 折射率: 1.632

生物活性

• 描述: Bicyclomycin 是一种 antibiotic。Bicyclomycin 对除了 Proteus 和Pseudomonas aeruginosa 以外的革兰氏阴性菌均有抗菌 (anti-Bacterial) 活性。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. NISHIDA, M., et al. BICYCLOMYCIN, A NEW ANTIBIOTIC. The Journal of Antibiotics, 25(10), 582–593.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : DT7470000 CHEMICAL NAME : Bicyclomycin CAS REGISTRY NUMBER : 38129-37-2 LAST UPDATED : 199309 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C12-H18-N2-O7 MOLECULAR WEIGHT : 302.32 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >4 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 25,569,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 5 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 4(1),235,1980 TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >4 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 25,569,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 4(1),235,1980

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