1366068-04-3

• 常用中文名：JWH-424
• 常用英文名：JWH-424
• CAS号：1366068-04-3
• 分子式：C₂₄H₂₂BrNO
• 分子量：420.342
• 发布时间：2017-08-23 23:12:55
• 更新时间：2024-01-14 21:18:59
• JWH 018 is a synthetic cannabinoid (CB) that potently activates the central CB1 and peripheral CB2 receptors (Ki = 9.0 and 2.94 nM, respectively). This cannabimimetic compound has frequently been found in herbal blends. JWH 424 is an 8-bromonaphthyl derivative of JWH 018 which shows a reduced selectivity for CB1 over CB2 (Ki = 20.9 and 5.4 nM, respectively).

名称

• 英文名: (8-bromonaphthalen-1-yl)-(1-pentylindol-3-yl)methanone
• 英文别名: JWH-424; Methanone, (8-bromo-1-naphthalenyl)(1-pentyl-1H-indol-3-yl)-; (8-Bromo-1-naphthyl)(1-pentyl-1H-indol-3-yl)methanone

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 572.4±25.0 °C at 760 mmHg
• 分子式: C₂₄H₂₂BrNO
• 分子量: 420.342
• 闪点: 300.0±23.2 °C
• 精确质量: 419.088470
• PSA: 22.00000
• LogP: 7.63
• 蒸汽压: 0.0±1.6 mmHg at 25°C
• 折射率: 1.628

合成路线

59529-21-4 56268-44-1 ~79% 1366068-04-3

文献：Wiley, Jenny L.; Smith, Valerie J.; Chen, Jianhong; Martin, Billy R.; Huffman, John W. Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 6 p. 2067 - 2081

1729-99-3 ~% 1366068-04-3

文献：Wiley, Jenny L.; Smith, Valerie J.; Chen, Jianhong; Martin, Billy R.; Huffman, John W. Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 6 p. 2067 - 2081

6314-27-8 ~% 1366068-04-3

文献：Wiley, Jenny L.; Smith, Valerie J.; Chen, Jianhong; Martin, Billy R.; Huffman, John W. Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 6 p. 2067 - 2081

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