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171596-36-4

171596-36-4结构式

品牌	规格	纯度	市场价	会员价	操作
TargetMol	1ml	99.42%;1 mL * 10 mM (in DMSO)	￥815.00	￥652.00	购买
TargetMol	1mg	99.42%	￥315.00	￥252.00	购买
索莱宝	1mg	≥98%	￥540.00	￥432.00	购买
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中文名	去甲基他达那非
英文名	Nortadalafil
英文别名	Pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione, 6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-, (6R,12aR)- CS-0823 N-Desmethyl Tadalafil (6R,12aR)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione Tadalafil Impurity 21

描述	Nortadalafil是demethyl Tadalafil,为PDE5抑制剂。
相关类别	信号通路 >> 代谢酶/蛋白酶 >> 磷酸二酯酶(PDE) 研究领域 >> 心血管疾病
参考文献	[1]. Beghyn, et al. PDE5 inhibitors: An original access to novel potent arylated analogues of tadalafil. Bioorganic & Medicinal Chemistry Letters (2007), 17(3), 789-792. [2]. Daugan, et al. The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione analogue. Journal of Medicinal Chemistry (2003), 46(21), 4533-4542. [3]. Porst H, et al. Chronic PDE-5 inhibition in patients with erectile dysfunction - a treatment approach using tadalafil once-daily. Expert Opin Pharmacother. 2012 Jul;13(10):1481-94. [4]. Frey MK, Lang I. Tadalafil for the treatment of pulmonary arterial hypertension. Expert Opin Pharmacother. 2012 Apr;13(5):747-55.

171489-59-1

~70%

171596-36-4

文献：Beghyn, Terence; Hounsou, Candide; Deprez, Benoit P. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 3 p. 789 - 792

171596-41-1

171596-36-4

文献：Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 3 p. 789 - 792

4299-70-1

171596-36-4

文献：Journal of Medicinal Chemistry, , vol. 46, # 21 p. 4533 - 4542

120-57-0

171596-36-4

文献：Journal of Medicinal Chemistry, , vol. 46, # 21 p. 4533 - 4542

14907-27-8

171596-36-4

文献：Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 3 p. 789 - 792