320345-99-1

• 常用中文名：阿地溴铵
• 常用英文名：Aclidinium bromide
• CAS号：320345-99-1
• 分子式：C₂₆H₃₀BrNO₄S₂
• 分子量：564.555
• 相关类别： 生物化工 抑制剂 神经信号通路(Neuronal Signaling) AChR 抑制剂
• 发布时间：2018-03-02 08:00:00
• 更新时间：2024-01-02 10:39:48
• 溴化Aclidinium(LAS 34273; LAS-W 330)是长效的可吸入型毒蕈碱拮抗剂,可用于慢性阻塞性肺病(COPD)的维持治疗。

名称

• 中文名: 阿地溴铵
• 英文名: aclidinium bromide
• 中文别名: (3R)-(2-羟基-2,2-二噻吩-2-基乙酰氧基)-1-(3-苯氧丙基)-1-氮杂双环[2.2.2]辛烷溴化物; 盐酸氯己定
• 英文别名: [(3R)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octan-3-yl] 2-hydroxy-2,2-dithiophen-2-ylacetate,bromide; UNII-UQW7UF9N91; 1-Azoniabicyclo[2.2.2]octane, 3-[(2-hydroxy-2,2-di-2-thienylacetyl)oxy]-1-(3-phenoxypropyl)-, bromide, (3R)- (1:1); Tudorza Pressair; LAS W-330; (3R)-3-[2-Hydroxy(di-2-thienyl)acetoxy]-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide; Eklira; Bretaris; Aclidinium bromide; (3R)-3-(2-Hydroxy-2,2-di(thiophen-2-yl)acetoxy)-1-(3-phenoxypropyl)quinuclidin-1-ium bromide; Aclidinium (Bromide)

物化性质

• 分子式: C₂₆H₃₀BrNO₄S₂
• 分子量: 564.555
• 精确质量: 563.079956
• PSA: 112.24000
• LogP: 1.62960
• 储存条件: 室温，干燥

生物活性

• 描述: 溴化Aclidinium(LAS 34273; LAS-W 330)是长效的可吸入型毒蕈碱拮抗剂,可用于慢性阻塞性肺病(COPD)的维持治疗。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 由mAChR
  信号通路 >> 神经信号通路 >> mAChR
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Cazzola M. Aclidinium bromide, a novel long-acting muscarinic M3 antagonist for the treatment of COPD. Curr Opin Investig Drugs. 2009 May;10(5):482-90.

  [2]. Joos GF. Potential for long-acting muscarinic antagonists in chronic obstructive pulmonary disease. Expert Opin Investig Drugs. 2010 Feb;19(2):257-64.

  [3]. Sentellas S, Ramos I, Albertí J et al. Aclidinium bromide, a new, long-acting, inhaled muscarinic antagonist: in vitro plasma inactivation and pharmacological activity of its main metabolites. Eur J Pharm Sci. 2010 Mar 18;39(5):283-90.

  [4]. Sims MW, Panettieri RA Jr. Profile of aclidinium bromide in the treatment of chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2011;6:457-66.