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109-86-4

109-86-4结构式
109-86-4结构式
  • 常用中文名：乙二醇甲醚
  • 常用英文名：2-methoxyethanol
  • CAS号：109-86-4
  • 分子式：C3H8O2
  • 分子量：76.094
  • 相关类别： 有机原料 醚类化合物及其衍生物 醚、醚醇
  • 发布时间：2018-02-07 08:00:00
  • 更新时间：2024-01-02 08:33:39
  • 【用途一】
    用作涂料溶剂、渗透剂、匀染剂及有机合成中间体，也用作喷气燃料的添加剂
    【用途二】
    用作测定铁、硫酸盐和二硫化碳的试剂及溶剂
    【用途三】
    2-甲氧基乙醇又称乙二醇单醚，是除草剂醚磺隆的中间体，也是各种油脂类硝基纤维素和合成树脂的溶剂。
    【用途四】
    该品用作各种油脂类、木质素、硝基纤维素、乙酸纤维素、醇溶性染料和合成树脂的溶剂；测定铁、硫酸盐和二硫化碳的试剂，涂层的稀释剂，并用于玻璃纸的包装封口、快干清漆和瓷漆中。也可用作染料工业的渗透剂和匀染剂，或作增塑剂、光亮剂。作为有机化合物生产的中间体，乙二醇单甲醚主要用于醋酸酯及乙二醇二甲醚的合成。也是生产二（2-甲氧乙基）苯二甲酸酯增塑剂的原料。乙二醇单甲醚与甘油和混合物（醚：甘油=98：2）是军用喷气燃料添加剂，可防结冰和抗细菌腐蚀。当乙二醇单甲醚作为喷气燃料防浆剂时，一般加入量为0.15%±0.05%，它具有很好的亲水性，在燃料中以其本身的羟基与油中微量水的分子间形成氢键缔合，加之本身的冰点很低，因而降低了油中水的结冰点，使其水能成冰霜析出，乙二醇单甲醚也是防微生物的添加剂。
    【用途五】
    测定铁；硫酸盐和二硫化碳的试剂，用作各种油脂类；木质素；硝基纤维素；乙酸纤维素；醇溶性染料和合成树脂的溶剂

化源商城直购

中文名 乙二醇甲醚
英文名 2-methoxyethanol
中文别名 2-甲氧基乙醇
乙二醇一甲醚
乙二醇单甲醚
乙二醇独甲醚
羟乙基·甲基醚
甲氧基乙醇
英文别名 Ethylene glycol monomethyl ether,Methyl glycol
SOLVENT S
H2O
2-methoxy-ethanol
dowanol7
EGM
TAP-WATER
monoethylene glycol methyl ether
MECS
EINECS 203-713-7
1-hydroxy-2-methoxy-ethane
ethylene glycol monomethyl ether
Prist
2-hydroxyethyl methyl ether
O-Methyl Glycol
WATER G
2-Methoxy-aethanol
Methyl Cellosolve
glycol monomethyl ether
Egme
2-Methoxyethanol
MFCD00081734
密度 0.965
沸点 124 ºC
熔点 -85 °C
分子式 C3H8O2
分子量 76.094
闪点 38 ºC
精确质量 76.052429
PSA 29.46000
LogP -0.80
外观性状 无色透明液体
蒸汽密度 2.62 (vs air)
蒸汽压 6.0±0.4 mmHg at 25°C
折射率 1.402
储存条件

储存注意事项储存于阴凉、通风的库房。远离火种、热源。库温不宜超过37℃。包装要求密封，不可与空气接触。应与氧化剂等分开存放，切忌混储。采用防爆型照明、通风设施。禁止使用易产生火花的机械设备和工具。储区应备有泄漏应急处理设备和合适的收容材料。
稳定性

1.具有醇和醚的化学性质，可与邻苯二甲酸、蓖麻酸、油酸等生成酯。

2.稳定性 稳定

3.禁配物 酰基氯、酸酐、强氧化剂

4.避免接触的条件 空气、光照

5.聚合危害 不聚合
水溶解性 SOLUBLE
分子结构

1、摩尔折射率：19.22

2、摩尔体积（cm3/mol）：81.9

3、等张比容（90.2K）：187.9

4、表面张力（dyne/cm）：27.6

5、极化率（10-24cm3）：7.62
计算化学

1、疏水参数计算参考值（XlogP）：-0.8

2、氢键供体数量：1

3、氢键受体数量：2

4、可旋转化学键数量：2

5、互变异构体数量：

6、拓扑分子极性表面积（TPSA）：29.5

7、重原子数量：5

8、表面电荷：0

9、复杂度：14.4

10、同位素原子数量：0

11、确定原子立构中心数量：0

12、不确定原子立构中心数量：0

13、确定化学键立构中心数量：0

14、不确定化学键立构中心数量：0

15、共价键单元数量：1
更多

1.性状：无色液体，略有醚的气味。

2.熔点（℃）：-85.1

3.沸点（℃）：124.5

4.相对密度（水=1）：0.97（20℃）

5.相对蒸气密度（空气=1）：2.62

6.饱和蒸气压（kPa）：1.29（25℃）

7.燃烧热（kJ/mol）：-399.5

8.临界温度（℃）：324.45

9.临界压力（MPa）：5.285

10.辛醇/水分配系数：-0.77

11.闪点（℃）：39

12.引燃温度（℃）：285

13.爆炸上限（%）：14

14.爆炸下限（%）：1.8

15.溶解性：与水混溶，可混溶于醇类、酮类、烃类。

16.折射率（n20ºC）：1.4028

17.折射率（n25ºC）：1.4013

18.黏度（mPa·s,20ºC）：1.72

19.黏度（mPa·s,25ºC）：1.60

20.闪点（ºC,闭口）：43

21.闪点（ºC,开口）：461

22.比热容（KJ/(kg·K),25ºC,定压）：2.20

23.电导率（S/m,20ºC）：1.09×10-6

24.蒸气压（kPa,25ºC）：1.3

25.蒸气压（kPa,27ºC）：1.3

26.蒸气压（kPa,56ºC）：6.7

27.体膨胀系数（K-1,20ºC）：0.00095

28.临界密度（g·cm-3）：0.281

29.临界体积（cm3·mol-1）：263

30.临界压缩因子：0.280

31.偏心因子：0.731

32.溶度参数(J·cm-3)0.5：23.204

33.van der Waals面积（cm2·mol-1）：6.880×109

34.van der Waals体积（cm3·mol-1）：45.870
第一部分：化学品名称
化学品中文名称：
乙二醇甲醚
化学品英文名称：
ethylene glycol monomethyl ether
中文名称 2 ：
2- 甲氧基乙醇
英文名称 2 ：
2-methoxyethanol
技术说明书编码：
394
CAS No. ：
109-86-4
分子式：
C3H8O2
分子量：
76.09
第二部分：成分 / 组成信息
有害物成分
含量
CAS No.
乙二醇甲醚
109-86-4
第三部分：危险性概述
危险性类别：
侵入途径：
健康危害：
吸入本品蒸气引起无力、失眠、头痛、胃肠功能紊乱、夜尿、体重减轻、眼烧灼感、反应迟钝、嗜睡。误服可致死。慢性中毒：神经衰弱综合征、大细胞性贫血、白细胞减少；严重者呈中毒性脑病和脑萎缩。
环境危害：
燃爆危险：
本品易燃，具刺激性。
第四部分：急救措施
皮肤接触：
脱去污染的衣着，用肥皂水和清水彻底冲洗皮肤。
眼睛接触：
提起眼睑，用流动清水或生理盐水冲洗。就医。
吸入：
迅速脱离现场至空气新鲜处。保持呼吸道通畅。如呼吸困难，给输氧。如呼吸停止，立即进行人工呼吸。就医。
食入：
饮足量温水，催吐。就医。
第五部分：消防措施
危险特性：
易燃，遇明火、高热或与氧化剂接触，有引起燃烧爆炸的危险。接触空气或在光照条件下可生成具有潜在爆炸危险性的过氧化物。
有害燃烧产物：
一氧化碳、二氧化碳。
灭火方法：
尽可能将容器从火场移至空旷处。喷水保持火场容器冷却，直至灭火结束。处在火场中的容器若已变色或从安全泄压装置中产生声音，必须马上撤离。灭火剂：抗溶性泡沫、干粉、二氧化碳、砂土。
第六部分：泄漏应急处理
应急处理：
迅速撤离泄漏污染区人员至安全区，并进行隔离，严格限制出入。切断火源。建议应急处理人员戴自给正压式呼吸器，穿防静电工作服。尽可能切断泄漏源。防止流入下水道、排洪沟等限制性空间。小量泄漏：用砂土或其它不燃材料吸附或吸收。也可以用大量水冲洗，洗水稀释后放入废水系统。大量泄漏：构筑围堤或挖坑收容。用泡沫覆盖，降低蒸气灾害。用防爆泵转移至槽车或专用收集器内，回收或运至废物处理场所处置。
第七部分：操作处置与储存
操作注意事项：
密闭操作，全面通风。操作人员必须经过专门培训，严格遵守操作规程。建议操作人员佩戴过滤式防毒面具（半面罩），戴化学安全防护眼镜，穿防静电工作服，戴橡胶耐油手套。远离火种、热源，工作场所严禁吸烟。使用防爆型的通风系统和设备。防止蒸气泄漏到工作场所空气中。避免与氧化剂接触。充装要控制流速，防止静电积聚。搬运时要轻装轻卸，防止包装及容器损坏。配备相应品种和数量的消防器材及泄漏应急处理设备。倒空的容器可能残留有害物。
储存注意事项：
储存于阴凉、通风的库房。远离火种、热源。库温不宜超过 30 ℃。包装要求密封，不可与空气接触。应与氧化剂等分开存放，切忌混储。采用防爆型照明、通风设施。禁止使用易产生火花的机械设备和工具。储区应备有泄漏应急处理设备和合适的收容材料。
第八部分：接触控制 / 个体防护
职业接触限值
中国 MAC(mg/m3) ：
未制定标准
前苏联 MAC(mg/m3) ：
未制定标准
TLVTN ：
OSHA 25ppm; ACGIH 5ppm,16mg/m3[ 皮 ]
TLVWN ：
未制定标准
监测方法：
工程控制：
生, 产过程密闭，全面通风。提供安全淋浴和洗眼设备。
呼吸系统防护：
空气中浓度超标时，佩戴过滤式防毒面具（半面罩）。高浓度环境中，佩戴自给式呼吸器或长管面具。
眼睛防护：
戴化学安全防护眼镜。
身体防护：
穿防静电工作服。
手防护：
戴橡胶耐油手套。
其他防护：
工作现场禁止吸烟、进食和饮水。工作完毕，淋浴更衣。注意个人清洁卫生。
第九部分：理化特性
主要成分：
纯品
外观与性状：
无色液体，略有气味。
pH ：
熔点 ( ℃ ) ：
-86.5
沸点 ( ℃ ) ：
124.5
相对密度 ( 水 =1) ：
0.97
相对蒸气密度 ( 空气 =1) ：
2.62
饱和蒸气压 (kPa) ：
0.83(20℃)
燃烧热 (kJ/mol) ：
1841.7
临界温度 ( ℃ ) ：
无资料
临界压力 (MPa) ：
无资料
辛醇 / 水分配系数的对数值：
-0.503
闪点 ( ℃ ) ：
39
引燃温度 ( ℃ ) ：
285
爆炸上限 %(V/V) ：
2.3
爆炸下限 %(V/V) ：
24.5
溶解性：
与水混溶，可混溶于醇、酮、烃类。
主要用途：
用作溶剂。
其它理化性质：
第十部分：稳定性和反应活性
稳定性：
禁配物：
酰基氯、酸酐、强氧化剂。
避免接触的条件：
聚合危害：
分解产物：
第十一部分：毒理学资料
急性毒性：
LD50 ： 2460 mg/kg( 大鼠经口 ) ； 2000 mg/kg( 兔经皮 )

LC50 ： 4665mg/m3 ， 7 小时 ( 大鼠吸入 )
亚急性和慢性毒性：
刺激性：
家兔经眼： 500mg/24 小时，轻度刺激。家兔经皮： 483mg/24 小时，轻度刺激。
致敏性：
致突变性：
致畸性：
致癌性：
第十二部分：生态学资料
生态毒理毒性：
生物降解性：
非生物降解性：
生物富集或生物积累性：
其它有害作用：
无资料。
第十三部分：废弃处置
废弃物性质：
废弃处置方法：
不含过氧化物的废液经浓缩后，控制一定的速度燃烧。含过氧化物的废液经浓缩后，在安全距离外敞口燃烧。
废弃注意事项：
第十四部分：运输信息
危险货物编号：
33569
UN 编号：
1188
包装标志：
包装类别：
O53
包装方法：
小开口钢桶；螺纹口玻璃瓶、铁盖压口玻璃瓶、塑料瓶或金属桶（罐）外普通木箱；螺纹口玻璃瓶、塑料瓶或镀锡薄钢板桶（罐）外满底板花格箱、纤维板箱或胶合板箱。
运输注意事项：
运输时运输车辆应配备相应品种和数量的消防器材及泄漏应急处理设备。夏季最好早晚运输。运输时所用的槽（罐）车应有接地链，槽内可设孔隔板以减少震荡产生静电。严禁与氧化剂、食用化学品等混装混运。运输途中应防曝晒、雨淋，防高温。中途停留时应远离火种、热源、高温区。装运该物品的车辆排气管必须配备阻火装置，禁止使用易产生火花的机械设备和工具装卸。公路运输时要按规定路线行驶，勿在居民区和人口稠密区停留。铁路运输时要禁止溜放。严禁用木船、水泥船散装运输。
第十五部分：法规信息
法规信息
化学危险物品安全管理条例 (1987 年 2 月 17 日国务院发布 ) ，化学危险物品安全管理条例实施细则 ( 化劳发 [1992] 677 号 ) ，工作场所安全使用化学品规定 ([1996] 劳部发 423 号 ) 等法规，针对化学危险品的安全使用、生产、储存、运输、装卸等方面均作了相应规定；常用危险化学品的分类及标志 (GB 13690-92) 将该物质划为第 3.3 类高闪点易燃液体。
第十六部分：其他信息
参考文献：
填表时间：
填表部门：
数据审核单位：
修改说明：
其他信息：
MSDS 修改日期：

毒理学数据:

1.急性毒性

LD50：2370mg/kg（大鼠经口）；2000mg/kg（兔经皮）

LC50：1500ppm（7h）（大鼠吸入）

2.刺激性

家兔经皮：483mg（24h），轻度刺激。

家兔经眼：500mg（24h），轻度刺激。

3.亚急性与慢性毒性 家兔经口，0.1ml/（kg·d），7d，见暂时性血尿。加大剂量，可致衰竭、震颤、蛋白尿和血尿。尸检见严重肾损害。大鼠暴露于1.05g/m3，每天7h，每周5d，1月后见血液中幼稚白细胞增加。

4.致突变性 显性致死试验：大鼠经口500mg/kg。精子形态学：大鼠经口500mg/kg

5.致畸性 大、小鼠孕后不同时间或多代通过皮下、经口、吸入不同途径给予不同剂量，可致心血管系统、颅面部（包括鼻、舌）、胃肠系统、肌肉骨骼系统、中枢神经系统、泌尿生殖系统、肝胆管系统发育畸形。

6.其他 大鼠经口最低中毒剂量（TDLo）：175mg/kg（孕7~13d），致心血管（循环）系统发育异常。小鼠经口最低中毒剂量（TDLo）：250mg/kg（1d，雄性），影响精子生成（包括遗传物质、精子形态、活动力、计数）

生态学数据:

1.生态毒性

LC50：＞10000mg/L（96h）（蓝鳃太阳鱼）；15520mg/L（96h）（虹鳟鱼，一年生）

2.生物降解性

好氧生物降解性（h）：168~672

厌氧生物降解性（h）：672~2688

3.非生物降解性

水中光氧化半衰期（h）：7400~4.70×105

空气中光氧化半衰期（h）：5.7~57

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KL5775000
CHEMICAL NAME :
Ethanol, 2-methoxy-
CAS REGISTRY NUMBER :
109-86-4
BEILSTEIN REFERENCE NO. :
1731074
LAST UPDATED :
199801
DATA ITEMS CITED :
117
MOLECULAR FORMULA :
C3-H8-O2
MOLECULAR WEIGHT :
76.11
WISWESSER LINE NOTATION :
Q2O1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - guinea pig
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human
DOSE/DURATION :
3380 mg/kg
TOXIC EFFECTS :
Gastrointestinal - gastritis Liver - other changes Kidney, Ureter, Bladder - other changes
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Human
DOSE/DURATION :
25 ppm
TOXIC EFFECTS :
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2370 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - other changes
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1500 ppm/7H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2068 mg/kg
TOXIC EFFECTS :
Blood - other hemolysis with or without anemia
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2560 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay) Cardiac - other changes
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1480 ppm/7H
TOXIC EFFECTS :
Behavioral - analgesia Lungs, Thorax, or Respiration - dyspnea Kidney, Ureter, Bladder - hematuria
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2147 mg/kg
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in both tubules and glomeruli Blood - changes in spleen Blood - other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
890 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic Blood - other hemolysis with or without anemia
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1280 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
950 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic Gastrointestinal - other changes Kidney, Ureter, Bladder - other changes
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
400 ppm/6H/2W-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - multiple enzyme effects
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10206 mg/kg/21D-C
TOXIC EFFECTS :
Endocrine - changes in thymus weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - changes in testicular weight
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
500 mg/kg/10D-I
TOXIC EFFECTS :
Endocrine - changes in thymus weight Immunological Including Allergic - decreased immune response
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
300 ppm/6H/13W-I
TOXIC EFFECTS :
Blood - changes in leukocyte (WBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - changes in testicular weight
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
970 mg/m3/7H/5W-I
TOXIC EFFECTS :
Blood - changes in bone marrow (not otherwise specified) Blood - changes in spleen
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1000 ppm/6H/11D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition Blood - changes in bone marrow (not otherwise specified) Blood - changes in leukocyte (WBC) count
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
20 gm/kg/4W-I
TOXIC EFFECTS :
Blood - changes in other cell count (unspecified) Blood - changes in leukocyte (WBC) count Related to Chronic Data - changes in testicular weight
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
450 mg/kg/16D-I
TOXIC EFFECTS :
Blood - changes in other cell count (unspecified) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
29484 mg/kg/13W-C
TOXIC EFFECTS :
Endocrine - changes in thymus weight Blood - changes in platelet count Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3200 mg/kg/4D-I
TOXIC EFFECTS :
Endocrine - changes in thymus weight Immunological Including Allergic - decrease in humoral immune response
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
12110 mg/kg/2W-C
TOXIC EFFECTS :
Endocrine - changes in thymus weight Related to Chronic Data - changes in testicular weight
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
82 gm/kg/13W-C
TOXIC EFFECTS :
Endocrine - effect on menstrual cycle Endocrine - other changes Blood - changes in spleen
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1000 ppm/6H/11D-I
TOXIC EFFECTS :
Blood - changes in leukocyte (WBC) count Related to Chronic Data - changes in testicular weight
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
750 ppm/7H/12W-I
TOXIC EFFECTS :
Blood - microcytosis with or without anemia Blood - other changes
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
300 ppm/6H/13W-I
TOXIC EFFECTS :
Endocrine - changes in thymus weight Blood - changes in erythrocyte (RBC) count Related to Chronic Data - changes in testicular weight
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
65 gm/kg/13W-I
TOXIC EFFECTS :
Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - changes in testicular weight
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
175 mg/kg
SEX/DURATION :
female 7-13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
175 mg/kg
SEX/DURATION :
female 7-13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - parturition Reproductive - Effects on Newborn - biochemical and metabolic
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
15015 mg/kg
SEX/DURATION :
male 13 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
100 mg/kg
SEX/DURATION :
male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
350 mg/kg
SEX/DURATION :
female 9-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
68 mg/kg/4H
SEX/DURATION :
female 1-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
30 ppm/6H
SEX/DURATION :
male 65 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
100 ppm/6H
SEX/DURATION :
female 6-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - parturition Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) Reproductive - Effects on Newborn - live birth index (measured after birth)
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
100 ppm/6H
SEX/DURATION :
female 6-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
30 ppm/6H
SEX/DURATION :
male 13 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
DOSE :
11592 mg/kg
SEX/DURATION :
female 6-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) Reproductive - Effects on Embryo or Fetus - fetal death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
DOSE :
4375 mg/kg
SEX/DURATION :
male 7 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
DOSE :
2 gm/kg
SEX/DURATION :
female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
DOSE :
1 gm/kg
SEX/DURATION :
female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - gastrointestinal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
330 mg/kg
SEX/DURATION :
female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
190 mg/kg
SEX/DURATION :
female 14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - urogenital system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
190 mg/kg
SEX/DURATION :
female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
190 mg/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
600 mg/kg
SEX/DURATION :
female 6-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - live birth index (measured after birth) Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
440 mg/kg
SEX/DURATION :
female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - live birth index (measured after birth)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
250 mg/kg
SEX/DURATION :
female 13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
175 mg/kg
SEX/DURATION :
female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
2 gm/kg
SEX/DURATION :
female 7-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - Central Nervous System
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
500 mg/kg
SEX/DURATION :
female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
250 mg/kg
SEX/DURATION :
female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
6250 mg/kg
SEX/DURATION :
male 25 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
1000 ppm/6H
SEX/DURATION :
male 11 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
500 ppm/7H
SEX/DURATION :
male 5 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
50 ppm/6H
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Specific Developmental Abnormalities - urogenital system
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
50 ppm/6H
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - urogenital system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
1200 mg/kg
SEX/DURATION :
female 7-13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
3200 mg/kg
SEX/DURATION :
female 7-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
250 mg/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
DOSE :
250 mg/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
930 mg/kg
SEX/DURATION :
female 20-45 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - abortion Reproductive - Effects on Embryo or Fetus - fetal death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
633 mg/kg
SEX/DURATION :
female 20-45 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
300 ppm/6H
SEX/DURATION :
male 65 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
50 ppm/6H
SEX/DURATION :
female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - body wall Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system Reproductive - Specific Developmental Abnormalities - urogenital system
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
50 ppm/6H
SEX/DURATION :
female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - body wall Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
10 ppm/6H
SEX/DURATION :
female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
6250 mg/kg
SEX/DURATION :
male 25 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
DOSE :
65 gm/kg
SEX/DURATION :
male 65 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1562 mg/kg
SEX/DURATION :
male 25 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
TYPE OF TEST :
Dominant lethal test
TYPE OF TEST :
Sperm Morphology

MUTATION DATA

TEST SYSTEM :
Rodent - mouse
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 6,390,1984 *** REVIEWS *** ACGIH TLV-TWA 16 mg/m3 (5 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 13,747,1989 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 MSHA STANDARD-air:TWA 25 ppm (80 mg/m3) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,158,1971 OSHA PEL (Gen Indu):8H TWA 25 ppm (80 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 25 ppm (80 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 25 ppm (80 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 25 ppm (80 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 5 ppm (16 mg/m3);Skin JAN 1993 OEL-BELGIUM:TWA 5 ppm (16 mg/m3);Skin JAN 1993 OEL-DENMARK:TWA 5 ppm (16 mg/m3);Skin JAN 1993 OEL-FINLAND:TWA 25 ppm (80 mg/m3);STEL 40 ppm (120 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 5 ppm (16 mg/m3);Skin JAN 1993 OEL-GERMANY:TWA 5 ppm (15 mg/m3);Skin JAN 1993 OEL-HUNGARY:TWA 15 mg/m3;STEL 30 mg/m3;Skin JAN 1993 OEL-JAPAN:TWA 5 ppm (16 mg/m3);Skin JAN 1993 OEL-THE NETHERLANDS:TWA 5 ppm (16 mg/m3);Skin JAN 1993 OEL-THE PHILIPPINES:TWA 25 ppm (80 mg/m3);Skin JAN 1993 OEL-POLAND:TWA 50 mg/m3 JAN 1993 OEL-RUSSIA:TWA 5 ppm JAN 1993 OEL-SWEDEN:TWA 5 ppm (16 mg/m3);STEL 10 ppm (30 mg/m3);Skin JAN 1993 OEL-SWITZERLAND:TWA 5 ppm (15 mg/m3);STEL 10 ppm (30 mg/m3);Skin JAN 1993 OEL-TURKEY:TWA 25 ppm (80 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 5 ppm (16 mg/m3);Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO ETHYLENEGLYCOL MONOMETHYL ETHER-air:10H TWA 0.1 ppm (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 46240 No. of Facilities: 11165 (estimated) No. of Industries: 128 No. of Occupations: 102 No. of Employees: 103424 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 46240 No. of Facilities: 8042 (estimated) No. of Industries: 89 No. of Occupations: 86 No. of Employees: 168180 (estimated) No. of Female Employees: 53403 (estimated)

符号 GHS02 GHS07 GHS08
GHS02, GHS07, GHS08
信号词 Danger
危害声明 H226-H302 + H312 + H332-H360FD-H370-H373
警示性声明 P201-P210-P260-P280-P308 + P311-P370 + P378
个人防护装备 Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
危害码 (欧洲) T:Toxic
风险声明 (欧洲) R10;R20/21/22;R60;R61
安全声明 (欧洲) S53-S45-S36/37-S16-S26-S23
危险品运输编码 UN 1188 3/PG 3
WGK德国 3
RTECS号 ZC0110000
包装等级 III
危险类别 3
海关编码 2942000000

1.由环氧乙烷与甲醇反应而得。将甲醇加入三氟化硼乙醚络合物中，在搅拌下于25-30℃通入环氧乙烷，通完后温度自动升至38-45℃，将所得反应液用氢氰化钾-甲醇溶液中和至pH=8-9。回收甲醇，蒸馏，收集130℃以前的馏分即得粗品。再进行分馏，收集123-125℃馏分即为成品。

工业生产中，将环氧乙烷与无水甲醇在高温高压下反应，不需催化剂，可得高收率的产品。

109-86-4 preparation

2.其制备方法是将甲醇加入三氟化硼乙醚配合物中，在搅拌下于25～300℃通入环氧乙烷，通完后温度自动升到38～45℃，所得反应液用氢氧化钾甲醇溶液中和到pH=8～9，回收甲醇，蒸馏，再经分馏得产品。

精制方法：易含杂质有水、二甘醇一甲醚(甲基卡必醇)和微量的酸、醛等。实验室的精制方法是用无水碳酸钠干燥后分馏。若有过氧化物存在，可加氯化亚锡回流或将其通过活性氧化铝柱除去。脂肪族酮可加2,4-二硝基苯肼除去。也可用碳酸钾、硫酸钙、硫酸镁或硅胶作干燥剂。

3.将含量95%的三级纯乙二醇单甲醚与无水碳酸钠一起振荡，除去无机酸或有机酸杂质，再用无水硫酸钙干燥后蒸馏。

海关编码 2909499000
中文概述 2909499000 其他醚醇及其卤化、磺化、硝化或亚硝化衍生物. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:5.5% 普通关税:30.0%
申报要素 品名, 成分含量, 用途
Summary 2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

【109-86-4】化源网提供CAS号/CAS登录号109-86-4，CAS No.:109-86-4的msds、结构式、性质、英文名、生产厂家、作用/用途、分子式/化学式、密度、沸点、熔点等。CAS号查询109-86-4上化源网，专业又轻松。
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