150403-89-7

• 常用中文名：L-n6-(1-亚氨基乙基)赖氨酸双盐酸盐
• 常用英文名：L-NIL hydrochloride
• CAS号：150403-89-7
• 分子式：C₈H₁₉Cl₂N₃O₂
• 分子量：260.16100
• 相关类别： 信号通路 免疫及炎症 一氧化氮合酶
• 发布时间：2019-02-13 17:50:32
• 更新时间：2024-01-13 18:58:33
• L-NIL盐酸盐是一种诱导型NO合酶抑制剂,对于miNOS[1][2][3],其IC50为3.3μM。

名称

• 中文名: L-n6-(1-亚氨基乙基)赖氨酸双盐酸盐
• 英文名: l-n6-(1-iminoethyl)lysine dihydrochloride
• 英文别名: l-nil dihydrochloride; l-nil hcl; l-nil hydrochloride; l-nil; MFCD00270890

物化性质

• 沸点: 369ºC at 760 mmHg
• 熔点: 253-255ºC
• 分子式: C₈H₁₉Cl₂N₃O₂
• 分子量: 260.16100
• 闪点: 177ºC
• 精确质量: 259.08500
• PSA: 99.20000
• LogP: 2.95030
• 外观性状: 白色至灰白色固体
• 蒸汽压: 1.86E-06mmHg at 25°C
• 储存条件: −20°C

生物活性

• 描述: L-NIL盐酸盐是一种诱导型NO合酶抑制剂,对于miNOS[1][2][3],其IC50为3.3μM。
• 相关类别:
  信号通路 >> 免疫及炎症 >> 一氧化氮合酶
  研究领域 >> 炎症/免疫
• 靶点:

  IC50: 3.3 μM (mouse inducible NO synthase), 92 μM (rat brain constitutive NO synthase)[1].

• 体外研究: L-NIL对小鼠诱导型一氧化氮合酶(miNOS)和大鼠脑组织组成型一氧化氮合物(rcNOS)产生浓度依赖性抑制,对miNOS的抑制作用显著增强。具有miNOS和rcNOS的L-NIL的IC50值分别为3.3和92μm,表明L-NIL对miNOS的选择性高28倍。此外,L-NIL对miNOS的效力约为L-NMA或L-NNA的6倍[3]。
• 体内研究: L-零(10和30 mg/kg,IP)预防小鼠肾脏IR诱导的炎症、氧化应激和自噬[1]。动物模型：成年雄性Balb/c(20-25 g)[1]。剂量：10和30 毫克/千克。给药：CLP结束时和6时腹腔注射 脓毒症诱导后h。结果：与假手术小鼠相比,导致血浆NGAL显著增加。导致TLR4和IL1β显著降低蛋白质含量和聚集蛋白转录本。与溶媒处理的小鼠相比,NFAT5 mRNA水平增加。与载体处理的动物相比,促进AR蛋白表达的下降。
• 参考文献:

  [1]. Consuelo Pasten, et al. l-NIL prevents the ischemia and reperfusion injury involving TLR-4, GST, clusterin, and NFAT-5 in mice. Am J Physiol Renal Physiol. 2019 Apr 1;316(4):F624-F634.

  [2]. Sharon Angela Tanuseputero, et al. Intravenous Arginine Administration Downregulates NLRP3 Inflammasome Activity and Attenuates Acute Kidney Injury in Mice with Polymicrobial Sepsis. Mediators Inflamm. 2020 May 11;2020:3201635.

  [3]. Moore WM, et al. L-N6-(1-iminoethyl)lysine: a selective inhibitor of inducible nitric oxide synthase. J Med Chem. 1994 Nov 11;37(23):3886-8.

MSDS

Name: L-N6-(1-Iminoethyl)-lysine.dihydrochloride Material Safety Data Sheet Synonym: L-NIL.2HCl CAS: 150403-89-7 Section 1 - Chemical Product MSDS Name:L-N6-(1-Iminoethyl)-lysine.dihydrochloride Material Safety Data Sheet Synonym:L-NIL.2HCl Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 150403-89-7 L-N6-(1-Iminoethyl)-lysine.dihydrochlo 97 unlisted Hazard Symbols: XI Risk Phrases: 36/37/38 Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Irritating to eyes, respiratory system and skin.Hygroscopic (absorbs moisture from the air). Potential Health Effects Eye: Causes eye irritation. May cause chemical conjunctivitis. Skin: Causes skin irritation. May be harmful if absorbed through the skin. Ingestion: May cause irritation of the digestive tract. May be harmful if swallowed. Inhalation: Causes respiratory tract irritation. May be harmful if inhaled. Can produce delayed pulmonary edema. Chronic: No information found. Section 4 - FIRST AID MEASURES Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Ingestion: Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Wash mouth out with water. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation. Notes to Physician: Treat symptomatically and supportively. Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions. Provide ventilation. Section 7 - HANDLING and STORAGE Handling: Minimize dust generation and accumulation. Avoid breathing dust, vapor, mist, or gas. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use with adequate ventilation. Wash clothing before reuse. Storage: Store in a tightly closed container. Deep freeze (below -20C). Store protected from moisture. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 150403-89-7: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Solid Color: white to off-white Odor: odorless pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: Not available. Autoignition Temperature: Not available. Flash Point: Not available. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: Soluble. Specific Gravity/Density: Molecular Formula: C8H17N3O2.2HCl Molecular Weight: 260.0579 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Hygroscopic: absorbs moisture or water from the air. Conditions to Avoid: Dust generation, exposure to moist air or water. Incompatibilities with Other Materials: Strong oxidizing agents. Hazardous Decomposition Products: Hydrogen chloride, nitrogen oxides, carbon monoxide, carbon dioxide. Hazardous Polymerization: Will not occur. Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 150403-89-7: OL5640500 LD50/LC50: Not available. Carcinogenicity: L-N6-(1-Iminoethyl)-lysine.dihydrochloride - Not listed by ACGIH, IARC, or NTP. Other: See actual entry in RTECS for complete information. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Not regulated as a hazardous material. IMO Not regulated as a hazardous material. RID/ADR Not regulated as a hazardous material. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: XI Risk Phrases: R 36/37/38 Irritating to eyes, respiratory system and skin. Safety Phrases: S 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 37/39 Wear suitable gloves and eye/face protection. WGK (Water Danger/Protection) CAS# 150403-89-7: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 150403-89-7 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 150403-89-7 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 危害码 (欧洲): Xi
• 风险声明 (欧洲): R36/37/38
• 安全声明 (欧洲): 26-36
• WGK德国: 3