36556-75-9

• 常用中文名：盐酸香豆心安
• 常用英文名：bucumolol hydrochloride
• CAS号：36556-75-9
• 分子式：C₁₇H₂₄ClNO₄
• 分子量：341.83000
• 发布时间：2018-03-26 08:00:00
• 更新时间：2024-01-20 16:47:43

名称

• 中文名: 盐酸香豆心安
• 英文名: 8-[3-(tert-butylamino)-2-hydroxypropoxy]-5-methylchromen-2-one,hydrochloride
• 英文别名: dl-5-methyl-8-(2-hydroxy-3-t-butylaminopropoxy)coumarin hydrochloride; Bucumarol; 8-(3-tert-Butylamino-2-hydroxy)propoxy-5-methylcoumarin hydrochloride; 5-Methyl-8-(2-hydroxy-3-t-butylaminopropoxy)coumarin hydrochloride,dl; 2H-1-Benzopyran-2-one,8-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)-5-methyl-,hydrochloride,(+-); Bucumolol hydrochloride; bucumolol monohydrochloride,(+-)-isomer; CS 359

物化性质

• 沸点: 490.7ºC at 760mmHg
• 分子式: C₁₇H₂₄ClNO₄
• 分子量: 341.83000
• 闪点: 250.6ºC
• 精确质量: 341.13900
• PSA: 71.70000
• LogP: 3.42210
• 储存条件: 库房通风低温干燥

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : DJ3028000 CHEMICAL NAME : 2H-1-Benzopyran-2-one, 8-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)-5-m ethyl-, hydrochloride, (+-)- CAS REGISTRY NUMBER : 36556-75-9 LAST UPDATED : 198706 DATA ITEMS CITED : 8 MOLECULAR FORMULA : C17-H23-N-O4.Cl-H MOLECULAR WEIGHT : 341.87 WISWESSER LINE NOTATION : T66 BOVJ G1 JO1YQ1MX1&1&1 &GH HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 676 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 24,131,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 59200 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 24,131,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 82300 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 24,131,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 31600 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 24,131,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 676 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 13,349,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 59200 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 13,349,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 82300 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 13,349,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 31600 ug/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression REFERENCE : JJPAAZ Japanese Journal of Pharmacology. (Japanese Pharmacological Soc., c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto 606, Japan) V.1- 1951- Volume(issue)/page/year: 23,497,1973