2061-64-5

• 常用中文名：过氧麦角甾醇
• 常用英文名：Ergosterol endoperoxide
• CAS号：2061-64-5
• 分子式：C₂₈H₄₄O₃
• 分子量：428.647
• 相关类别： 天然产物 甾体化合物
• 发布时间：2018-12-04 11:28:25
• 更新时间：2024-01-02 12:18:44
• 麦角甾醇过氧化物是一种甾体衍生物,可从多种真菌、酵母、地衣或海绵中分离得到。麦角甾醇过氧化物具有抗肿瘤、促凋亡、抗炎、抗分枝杆菌和抗增殖活性[1][2]。

名称

• 中文名: 5Alpha,8Alpha-表二氧-(22E,24R)-麦角甾-6,22-二烯-3Β-醇
• 英文名: ergosterol peroxide
• 中文别名: 5Α,8Α-表二氧-(22E,24R)-麦角甾-6,22-二烯-3Β-醇; 5Α,8Α-表二氧-(22E,24R)-麦角甾-6,22-二烯-3Β-醇; 过氧麦角甾醇
• 英文别名: 5α,8α-epidioxy-22E-ergosta-6,22-dien-3β-ol; Ergosterol peroxide; Peroxyergosterol; (3S,5S,8S,9R,10R,13R,14R,17R)-17-[(2R,3E,5R)-5,6-dimethylhept-3-en-2-yl]-10,13-dimethyl-1,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-2H-5,8-epidioxycyclopenta[a]phenanthren-3-ol; 3b,5a-Etheno-1H-benz[c]indeno[5,4-e][1,2]dioxin-7-ol, 2,3,3a,6,7,8,9,9a,9b,10,11,11a-dodecahydro-9a,11a-dimethyl-1-[(1R,2E,4R)-1,4,5-trimethyl-2-hexen-1-yl]-, (1R,3aR,3bS,5aS,7S,9aR,9bR,11aR)-; UNII:UG9TN81TGH; Ergosterol endoperoxide; (1S,2R,5R,6R,9R,10R,13S,15S)-5-[(2R,3E,5R)-5,6-Dimethyl-3-hepten-2-yl]-6,10-dimethyl-16,17-dioxapentacyclo[13.2.2.0.0.0]nonadec-18-en-13-ol; Ergosterol 5.alpha.,8.alpha.-epidioxide; Ergosterol 5.α.,8.α.-epidioxide; ergosterol-5,8-peroxide; 5α,8α-Ergosta-6,22-dien-3β-ol, 5,8-epidioxy-

物化性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 499.7±45.0 °C at 760 mmHg
• 分子式: C₂₈H₄₄O₃
• 分子量: 428.647
• 闪点: 256.0±28.7 °C
• 精确质量: 428.329041
• PSA: 38.69000
• LogP: 7.68
• 外观性状: 粉末
• 蒸汽压: 0.0±2.9 mmHg at 25°C
• 折射率: 1.552
• 储存条件: 2-8℃，干燥，密闭

生物活性

• 描述: 麦角甾醇过氧化物是一种甾体衍生物,可从多种真菌、酵母、地衣或海绵中分离得到。麦角甾醇过氧化物具有抗肿瘤、促凋亡、抗炎、抗分枝杆菌和抗增殖活性[1][2]。
• 相关类别:
  研究领域 >> 癌症
  研究领域 >> 炎症/免疫
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. Ming Bu, et al. Synthesis of Ergosterol Peroxide Conjugates as Mitochondria Targeting Probes for Enhanced Anticancer Activity. Molecules. 2019 Sep 11;24(18):3307

  [2]. Taotao Ling, et al. Development of ergosterol peroxide probes for cellular localisation studies. Org Biomol Chem. 2019 May 29;17(21):5223-5229.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : KE7289000 CHEMICAL NAME : 5-alpha,8-alpha-Ergosta-6,22-dien-3-beta-ol, 5,8-epidioxy- CAS REGISTRY NUMBER : 2061-64-5 BEILSTEIN REFERENCE NO. : 0096852 LAST UPDATED : 199612 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C28-H44-O3 MOLECULAR WEIGHT : 428.72 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 30 mg/kg SEX/DURATION : female 1 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) REFERENCE : JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 46,461,1976 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 60 mg/kg SEX/DURATION : female 6-7 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - abortion REFERENCE : JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 46,461,1976

安全

• 危害码 (欧洲): Xi

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