1404-19-9

• 常用中文名：寡霉素
• 常用英文名：Oligomycin
• CAS号：1404-19-9
• 分子式：C₁₃₅H₂₂₀O₃₃
• 分子量：2371.171
• 相关类别： 原料药 抗生素类药物 其它抗生素类药
• 发布时间：2018-03-29 08:00:00
• 更新时间：2024-01-03 11:19:46
• 寡霉素是由链霉菌属产生的大环内酯类化合物,通过其抑制线粒体膜结合ATP合成酶的能力,对其他生物体具有毒性。线粒体F1FO-ATP合成酶可在缺血期间转换为ATP水解酶,因此,在这些条件下,寡粘菌素的抑制将减少ATP的消耗,而不是阻碍ATP的合成。

名称

• 中文名: 寡霉素
• 英文名: Oligomycin
• 英文别名: Oligomycin From Streptomyces Diastatochromogenes; EINECS 215-767-9; MFCD00065705

物化性质

• 密度: 1.14 g/cm3
• 沸点: 886.3ºC at 760 mmHg
• 熔点: 84-100ºC
• 分子式: C₁₃₅H₂₂₀O₃₃
• 分子量: 2371.171
• 闪点: 252ºC
• 精确质量: 2369.553711
• PSA: 536.99000
• LogP: 17.71190
• 外观性状: 灰白色至白色粉末
• 蒸汽压: 0mmHg at 25°C
• 折射率: 1.543
• 储存条件:

  密封、在 -20 ºC下保存

• 稳定性:

  如果遵照规格使用和储存则不会分解，未有已知危险反应，避免氧化物

• 水溶解性: Sparingly soluble in water. Soluble in DMSO (20mg/ml) and ethanol (30mg/ml) /n
• 分子结构:

  1、 摩尔折射率：220.02

  2、 摩尔体积（m³/mol）：707.0

  3、 等张比容（90.2K）：1851.9

  4、 表面张力（dyne/cm）: 47.0

  5、 介电常数：无可用

  6、 偶极距（10 ^-24cm ³）：无可用

  7、 极化率：87.22

• 计算化学:

  1、 疏水参数计算参考值（XlogP）：7.1

  2、 氢键供体数量：5

  3、 氢键受体数量：11

  4、 可旋转化学键数量：3

  5、 互变异构体数量：6

  6、 拓扑分子极性表面积（TPSA）：180

  7、 重原子数量：56

  8、 表面电荷：0

  9、 复杂度：1390

  10、 同位素原子数量：0

  11、 确定原子立构中心数量：0

  12、 不确定原子立构中心数量：18

  13、 确定化学键立构中心数量：3

  14、 不确定化学键立构中心数量：0

  15、 共价键单元数量：1

• 更多:

  1. 性状：粉末

  2. 密度（g/mL,25/4℃）： 未确定

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC）：84-100

  5. 沸点（ºC,常压）：未确定

  6. 沸点（ºC,5.2kPa）： 未确定

  7. 折射率： 未确定

  8. 闪点（ºC）： 未确定

  9. 比旋光度（º）： 未确定

  10. 自燃点或引燃温度（ºC）： 未确定

  11. 蒸气压（kPa,25ºC）： 未确定

  12. 饱和蒸气压（kPa,60ºC）： 未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）： 未确定

  15. 临界压力（KPa）： 未确定

  16. 油水（辛醇/水）分配系数的对数值： 未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）： 未确定

  19. 溶解性：不能溶解的

生物活性

• 描述: 寡霉素是由链霉菌属产生的大环内酯类化合物,通过其抑制线粒体膜结合ATP合成酶的能力,对其他生物体具有毒性。线粒体F1FO-ATP合成酶可在缺血期间转换为ATP水解酶,因此,在这些条件下,寡粘菌素的抑制将减少ATP的消耗,而不是阻碍ATP的合成。
• 相关类别:
  信号通路 >> 抗感染 >> 真菌
  信号通路 >> 跨膜转运 >> ATP合成酶

MSDS

Name: Oligomycin Mixture of A B and C Material Safety Data Sheet Synonym: None Known CAS: 1404-19-9 Section 1 - Chemical Product MSDS Name:Oligomycin Mixture of A B and C Material Safety Data Sheet Synonym:None Known Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 1404-19-9 Oligomycin, Mixture of A, B and C ca. 100% 215-767-9 Hazard Symbols: None Listed. Risk Phrases: None Listed. Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW The toxicological properties of this material have not been fully investigated. Potential Health Effects Eye: May cause eye irritation. Skin: May cause skin irritation. Ingestion: May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated. Inhalation: May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated. Chronic: No information found. Section 4 - FIRST AID MEASURES Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Ingestion: Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Runoff from fire control or dilution water may cause pollution. Extinguishing Media: Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions. Provide ventilation. Section 7 - HANDLING and STORAGE Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Storage: Keep container closed when not in use. Store in a tightly closed container. Deep freeze (below -20C). Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 1404-19-9: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Powder Color: off-white Odor: Not available. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: 150 deg C Autoignition Temperature: Not applicable. Flash Point: Not applicable. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: Specific Gravity/Density: Molecular Formula: Molecular Weight: Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: Incompatible materials, dust generation, excess heat, strong oxidants. Incompatibilities with Other Materials: Oxidizing agents. Hazardous Decomposition Products: Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide. Hazardous Polymerization: Has not been reported Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 1404-19-9: RK3325000 LD50/LC50: Not available. Carcinogenicity: Oligomycin, Mixture of A, B and C - Not listed by ACGIH, IARC, or NTP. Other: See actual entry in RTECS for complete information. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Not regulated as a hazardous material. IMO Not regulated as a hazardous material. RID/ADR Not regulated as a hazardous material. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: Not available. Risk Phrases: Safety Phrases: S 24/25 Avoid contact with skin and eyes. WGK (Water Danger/Protection) CAS# 1404-19-9: 3 Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 1404-19-9 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 1404-19-9 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

毒理学数据: 急性毒性：小鼠静脉LDLo：2500ug/kg；小鼠腹经LDLo：2500ug/kg； 生态学数据: 对是水稍微有危害的不要让未稀释或大量的产品接触地下水、水道或者污水系统，若无政府许可，勿将材料排入周围环境 CHEMICAL IDENTIFICATION RTECS NUMBER : RK3325000 CHEMICAL NAME : Oligomycin CAS REGISTRY NUMBER : 1404-19-9 LAST UPDATED : 199012 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 500 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AGACBH Agents and Actions, A Swiss Journal of Pharmacology. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1969/70- Volume(issue)/page/year: 15,660,1984 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2500 ug/kg TOXIC EFFECTS : Behavioral - muscle weakness Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression REFERENCE : ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 4,962,1954 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2500 ug/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea REFERENCE : ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 4,962,1954

安全

• 符号: GHS06
• 信号词: Danger
• 危害声明: H301
• 警示性声明: P301 + P310
• 个人防护装备: dust mask type N95 (US);Eyeshields;Faceshields;Gloves
• 危害码 (欧洲): Xn: Harmful;
• 风险声明 (欧洲): R22
• 安全声明 (欧洲): 24/25
• 危险品运输编码: UN 2811
• WGK德国: 3
• RTECS号: RK3325000
• 包装等级: III
• 危险类别: 6.1(b)