123562-20-9

123562-20-9结构式

常用中文名：内皮素2
常用英文名：Endothelin-2 (human, canine) acetate salt
CAS号：123562-20-9
分子式：C₁₁₅H₁₆₀N₂₆O₃₂S₄
分子量：2546.92000
相关类别：生物化工多肽
发布时间：2018-05-26 08:00:00
更新时间：2024-01-02 12:34:19
Endothelin-2, human是由21个氨基酸组成的血管活性肽，可与G蛋白连接的跨膜受体，ET-RA 和ET-RB 结合。

化源商城直购

中文名	内皮素2
英文名	h-cys-ser-cys-ser-ser-trp-leu-asp-lys-glu-cys-val-tyr-phe-cys-his-leu-asp-ile-ile-trp-oh
英文别名	Endothelin 2,human MFCD00133306 Endothelin-2,human Endothelin-2, human

描述	Endothelin-2, human是由21个氨基酸组成的血管活性肽,可与G蛋白连接的跨膜受体,ET-RA 和ET-RB 结合。
相关类别	信号通路 >> 其他 >> 其他研究领域 >> 心血管疾病多肽产品
靶点	ET-RA, ET-RB[1]
体外研究	在纳摩尔浓度下,内皮素-2表现出强烈且持久的血管收缩活性,特征是内皮素(EC50 = 0.52 nM)[1]。内皮素-2是巨噬细胞和THP-1单核细胞的化学引诱物,但不是新鲜分离的单核细胞。对内皮素-2的趋化反应显示出典型的钟形响应曲线。内皮素受体拮抗剂的实验表明,通过ET-RB受体介导向内皮素-2的迁移。肿瘤内皮素-2的表达可能调节巨噬细胞的行为,使活化的细胞在缺氧区域积聚[2]。
体内研究	两种不同的升压效应阶段通常见于内皮素-2：早期阶段紧随抑郁症反应,并在接下来的3-10分钟内占主导地位,而晚期升压效应在注射后10-20分钟发展并持续> 1小时[1]。
动物实验	大鼠[1]对于升压活性的测定，用氨基甲酸乙酯（1g / kg ip）麻醉重300-350g的雄性Wistar大鼠，并用阿托品（0.25mg / kg iv），普萘洛尔（1mg / kg iv）预处理。和bunazocine（1 mg / kg iv）。每3-4小时施用额外的维持剂量（初始剂量的一半）自主阻塞剂。每只动物仅给予一次内皮素-2大丸剂。从插入右股静脉的插管推注注射50μL缓冲液中的1nM内皮素-2。从套管记录血压，套管置于右颈动脉并连接到压力传感器[1]。
参考文献	[1]. Grimshaw MJ, et al. Endothelin-2 is a macrophage chemoattractant: implications for macrophage distribution in tumors. Eur J Immunol. 2002 Sep;32(9):2393-400.

分子式	C₁₁₅H₁₆₀N₂₆O₃₂S₄
分子量	2546.92000
精确质量	2545.06000
PSA	1025.62000
LogP	4.59880
外观性状	powder \| white
储存条件	密封、在 -20ºC下保存
稳定性	如果遵照规格使用和储存则不会分解，未有已知危险反应
计算化学	1.疏水参数计算参考值（XlogP）:-2.6 2.氢键供体数量:33 3.氢键受体数量:39 4.可旋转化学键数量:46 5.互变异构体数量:998 6.拓扑分子极性表面积1030 7.重原子数量:177 8.表面电荷:0 9.复杂度:5550 10.同位素原子数量:0 11.确定原子立构中心数量:0 12.不确定原子立构中心数量:23 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:1
更多	1. 性状：白色粉末 2. 密度（g/mL,20℃）：未确定 3. 相对蒸汽密度（g/mL,空气=1）：未确定 4. 熔点（ºC）：未确定 5. 沸点（ºC,常压）：未确定 6. 沸点（ºC,KPa）：未确定 7. 折射率：未确定 8. 闪点（ºC）：未确定 9. 比旋光度（º）：未确定 10. 自燃点或引燃温度（ºC）：未确定 11. 蒸气压（Pa,20ºC）：未确定 12. 饱和蒸气压（KPa,20ºC）：未确定 13. 燃烧热（KJ/mol）：未确定 14. 临界温度（ºC）：未确定 15. 临界压力（KPa）：未确定 16. 油水（辛醇/水）分配系数的对数值：未确定 17. 爆炸上限（%,V/V）：未确定 18. 爆炸下限（%,V/V）：未确定 19. 溶解性：未确定

Section1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE
Product identifiers
Product name: Endothelin 2, human
CAS-No.: 123562-20-9
Relevant identified uses of the substance or mixture and uses advised against
Identified uses: Laboratory chemicals, Manufacture of substances

Section2. HAZARDS IDENTIFICATION
Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008 [EU-GHS/CLP]
Acute toxicity, Inhalation (Category 2)
Acute toxicity, Dermal (Category 2)
Acute toxicity, Oral (Category 2)
Classification according to EU Directives 67/548/EEC or 1999/45/EC
Very toxic by inhalation, in contact with skin and if swallowed.
Label elements
Labelling according Regulation (EC) No 1272/2008 [CLP]
Pictogram
Signal wordDanger
Hazard statement(s)
H300Fatal if swallowed.
H310Fatal in contact with skin.
H330Fatal if inhaled.
Precautionary statement(s)
P260Do not breathe dust/ fume/ gas/ mist/ vapours/ spray.
P264Wash hands thoroughly after handling.
P280Wear protective gloves/ protective clothing.
P284Wear respiratory protection.
P302 + P350IF ON SKIN: Gently wash with plenty of soap and water.
P310Immediately call a POISON CENTER or doctor/ physician.
Supplemental Hazardnone
Statements
According to European Directive 67/548/EEC as amended.
Hazard symbol(s)
R-phrase(s)
R26/27/28Very toxic by inhalation, in contact with skin and if swallowed.
S-phrase(s)
S28After contact with skin, wash immediately with plenty of soap and water.
S36/37Wear suitable protective clothing and gloves.
S45In case of accident or if you feel unwell, seek medical advice immediately
(show the label where possible).
Caution - substance not yet tested completely.
Other hazards - none

Section3. COMPOSITION/INFORMATION ON INGREDIENTS
Substances
Formula: C115H160N26O32S4
Molecular Weight: 2.546,92 g/mol
ComponentConcentration
Endothelin 2, human
CAS-No.123562-20-9-

Section4. FIRST AID MEASURES
Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician.
In case of eye contact
Flush eyes with water as a precaution.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
Most important symptoms and effects, both acute and delayed
Indication of any immediate medical attention and special treatment needed
no data available

Section5. FIREFIGHTING MEASURES
Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, nitrogen oxides (NOx), Sulphur oxides
Advice for firefighters
Wear self contained breathing apparatus for fire fighting if necessary.
Further information
no data available

Section6. ACCIDENTAL RELEASE MEASURES
Personal precautions, protective equipment and emergency procedures
Wear respiratory protection. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate
ventilation. Evacuate personnel to safe areas. Avoid breathing dust.
Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
Methods and materials for containment and cleaning up
Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed
containers for disposal.
Reference to other sections
For disposal see section 13.

Section7. HANDLING AND STORAGE
Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols.
Provide appropriate exhaust ventilation at places where dust is formed.Normal measures for preventive fire
protection.
Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
Recommended storage temperature: -20 °C
hygroscopic Store under inert gas.
Specific end uses
no data available

Section8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Control parameters
Components with workplace control parameters
Exposure controls
Appropriate engineering controls
Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling
the product.
Personal protective equipment
Eye/face protection
Face shield and safety glasses Use equipment for eye protection tested and approved under
appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
(without touching glove's outer surface) to avoid skin contact with this product. Dispose of
contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
the standard EN 374 derived from it.
Body Protection
Complete suit protecting against chemicals, The type of protective equipment must be selected
according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection
Where risk assessment shows air-purifying respirators are appropriate use a full-face particle
respirator type N100 (US) or type P3 (EN 143) respirator cartridges as a backup to engineering
controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use
respirators and components tested and approved under appropriate government standards such
as NIOSH (US) or CEN (EU).

Section9. PHYSICAL AND CHEMICAL PROPERTIES
Information on basic physical and chemical properties
a) AppearanceForm: powder
Colour: white
b) Odourno data available
c) Odour Thresholdno data available
d) pHno data available
e) Melting point/freezingno data available
point
f) Initial boiling point and no data available
boiling range
g) Flash pointno data available
h) Evaporation rateno data available
i) Flammability (solid, gas) no data available
j) Upper/lowerno data available
flammability or
explosive limits
k) Vapour pressureno data available
l) Vapour densityno data available
m) Relative densityno data available
n) Water solubilityno data available
o) Partition coefficient: n- no data available
octanol/water
p) Autoignitionno data available
temperature
q) Decompositionno data available
temperature
r) Viscosityno data available
s) Explosive propertiesno data available
t) Oxidizing propertiesno data available
Other safety information
no data available

Section10. STABILITY AND REACTIVITY
Reactivity
no data available
Chemical stability
no data available
Possibility of hazardous reactions
no data available
Conditions to avoid
no data available
Incompatible materials
Strong oxidizing agents
Hazardous decomposition products
Other decomposition products - no data available

Section11. TOXICOLOGICAL INFORMATION
Information on toxicological effects
Acute toxicity
no data available
Skin corrosion/irritation
no data available
Serious eye damage/eye irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
IARC:No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
no data available
Specific target organ toxicity - single exposure
no data available
Specific target organ toxicity - repeated exposure
no data available
Aspiration hazard
no data available
Potential health effects
InhalationMay be fatal if inhaled. May cause respiratory tract irritation.
IngestionMay be fatal if swallowed.
SkinMay be fatal if absorbed through skin. May cause skin irritation.
EyesMay cause eye irritation.
Additional Information
RTECS: Not available

Section12. ECOLOGICAL INFORMATION
Toxicity
no data available
Persistence and degradability
no data available
Bioaccumulative potential
no data available
Mobility in soil
no data available
Results of PBT and vPvB assessment
no data available
Other adverse effects
no data available

Section13. DISPOSAL CONSIDERATIONS
Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed
professional waste disposal service to dispose of this material. Dissolve or mix the material with a
combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.
Contaminated packaging
Dispose of as unused product.

Section14. TRANSPORT INFORMATION
UN number
ADR/RID: 2811IMDG: 2811IATA: 2811
UN proper shipping name
ADR/RID: TOXIC SOLID, ORGANIC, N.O.S. (Endothelin 2, human)
IMDG: TOXIC SOLID, ORGANIC, N.O.S. (Endothelin 2, human)
IATA:Toxic solid, organic, n.o.s. (Endothelin 2, human)
Transport hazard class(es)
ADR/RID: 6.1IMDG: 6.1IATA: 6.1
Packaging group
ADR/RID: IIMDG: IIATA: I
Environmental hazards
ADR/RID: noIMDG Marine pollutant: noIATA: no
Special precautions for user
no data available

SECTION 15 - REGULATORY INFORMATION
N/A

SECTION 16 - ADDITIONAL INFORMATION
N/A

符号	GHS06
信号词	Danger
危害声明	H300 + H310 + H330
警示性声明	P260-P264-P280-P284-P301 + P310-P302 + P350
个人防护装备	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
危害码 (欧洲)	T+
风险声明 (欧洲)	R26/27/28
安全声明 (欧洲)	S28-S45-S36-S37
危险品运输编码	UN 2811 6.1/PG 1
WGK德国	3

123562-20-9	117399-94-7
349453-49-2	117399-93-6
121204-87-3	17942-08-4
1466427-02-0	55645-40-4
1408076-01-6	2322934-56-3
1158522-08-7	940364-43-2
134104-43-1	131615-57-1
2229093-14-3	6906-52-1
930439-75-1	1018584-77-4
1375289-11-4	849349-65-1