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盐酸格拉司琼

更新时间:2024-01-02 19:26:11

盐酸格拉司琼结构式
盐酸格拉司琼结构式
品牌特惠专场
常用名 盐酸格拉司琼 英文名 Granisetron hydrochloride
CAS号 107007-99-8 分子量 348.870
密度 1.33g/cm3 沸点 532ºC at 760mmHg
分子式 C18H25ClN4O 熔点 290-292°C
MSDS 中文版 美版 闪点 275.6ºC
符号 GHS07
GHS07
信号词 Warning

 盐酸格拉司琼用途


Granisetron(BRL 43694A)盐酸盐是5-HT3受体拮抗剂,可作为化疗后止吐剂。

 盐酸格拉司琼名称

中文名 盐酸格拉司琼
英文名 Granisetron hydrochloride
中文别名 1-甲基-N-[内向-9-甲基-9-氮杂双环(3,3,1)壬烷-3-基]-lH-吲唑-3-甲酰胺盐酸盐 | N-(内-9-甲基-9-氮杂二环[3,3,1]壬-3-基)-吲哚-3-羧酰胺盐酸盐 | 1-甲基-N-[内向-9-甲基-9-氮杂双环[3.3.1]壬烷-3-基]-1H-吲唑-3-甲酰胺盐酸盐 | 格拉司琼盐酸盐 | 桥-N-(9-甲基-9-氯杂二环[3.3.1]壬-3-基)-1-甲基-1H-吲唑-3-羧酰胺盐酸盐 | 1-甲基-N-[(3-endo)-9-甲基-9-氮杂双环[3.3.1]壬-3-基]-1H-吲哚-3-甲酰胺盐酸盐
英文别名 更多

 盐酸格拉司琼物理化学性质

密度 1.33g/cm3
沸点 532ºC at 760mmHg
熔点 290-292°C
分子式 C18H25ClN4O
分子量 348.870
闪点 275.6ºC
精确质量 348.171692
PSA 50.16000
LogP 3.44920
外观性状 白色至灰白色结晶固体
蒸汽压 0mmHg at 25°C
折射率 1.69
储存条件 Room temp
更多

1.性状:白色或微黄白色结晶性粉末,无臭。

2.熔点(℃):290-292。

3.溶解度:易溶于水,较难溶于甲醇,极难溶于乙醇,几不溶于乙醚。

 盐酸格拉司琼MSDS

 盐酸格拉司琼毒性和生态

盐酸格拉司琼毒理学数据:

急性毒性LD50、雌小鼠,雄、雌大鼠(mg/kg):17,25,14,16静脉注射。

盐酸格拉司琼毒性英文版

 盐酸格拉司琼安全信息

符号 GHS07
GHS07
信号词 Warning
危害声明 H302
警示性声明 P301 + P312 + P330
个人防护装备 dust mask type N95 (US);Eyeshields;Faceshields;Gloves
危害码 (欧洲) Xn: Harmful;Xi: Irritant;
风险声明 (欧洲) R22
安全声明 (欧洲) 26-36-37
危险品运输编码 NONH for all modes of transport
RTECS号 NK7882200
海关编码 2933990090

 盐酸格拉司琼合成线路

~%

盐酸格拉司琼结构式

盐酸格拉司琼

107007-99-8

文献:US4886808 A1, ;

~74%

盐酸格拉司琼结构式

盐酸格拉司琼

107007-99-8

文献:INKE, S.A. Patent: WO2008/151677 A1, 2008 ; Location in patent: Page/Page column 13 ;

 盐酸格拉司琼制备

化合物(I)和化合物(Ⅱ)反应,即得格拉司琼。用氯化氢-乙醇酸化,得到盐酸格拉司琼。107007-99-8 preparation

 盐酸格拉司琼海关

海关编码 2933990090
中文概述 2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素 品名, 成分含量, 用途, 乌洛托品请注明外观, 6-己内酰胺请注明外观, 签约日期
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 盐酸格拉司琼文献28

更多文献
Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude.

J. Neurosci. 35 , 9580-94, (2015)

Due to its distinct pharmacological profile and lower incidence of adverse events compared with other opioids, buprenorphine is considered a safe option for pain and substitution therapy. However, des...

In vitro percutaneous absorption enhancement of granisetron by chemical penetration enhancers.

Drug Dev. Ind. Pharm. 39(4) , 561-8, (2013)

Granisetron (GRN), a potent antiemetic agent, is frequently used to prevent nausea and vomiting induced by cancer cytotoxic chemotherapy and radiation therapy.As part of our efforts to further modify ...

Comparison of the efficacy of ondansetron and granisetron to prevent postoperative nausea and vomiting after laparoscopic cholecystectomy: a systematic review and meta-analysis.

Surg. Laparosc. Endosc. Percutan. Tech. 23(1) , 79-87, (2013)

Our purpose was to assess the prophylactic antiemetic effects of ondansetron versus granisetron for laparoscopic cholecystectomy.We searched Medline, Cochrane Central Register of Controlled Trials, Pu...

 盐酸格拉司琼英文别名

Granisetron hydrochloride
1-méthyl-N-[(3-endo)-9-méthyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide chlorhydrate
1H-Indazole-3-carboxamide, 1-methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-, hydrochloride (1:1)
1-Methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide hydrochloride (1:1)
1H-indazole-3-carboxamide, 1-methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-, monohydrochloride
MFCD01747034
Granisetron HCl
1-Methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide hydrochloride
1-Methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide
1-methyl-N-[(1S,5R)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]indazole-3-carboxamide,hydrochloride
1-Methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazol-3-carboxamidhydrochlorid
Granisetron (Hydrochloride)
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