HZ52

更新时间：2024-01-03 23:04:29

HZ52结构式	常用名	HZ52	英文名	HZ52
	CAS号	1077626-51-7	分子量	456.000
	密度	1.3±0.1 g/cm3	沸点	625.3±55.0 °C at 760 mmHg
	分子式	C₂₄H₂₆ClN₃O₂S	熔点	N/A
	MSDS	中文版美版	闪点	332.0±31.5 °C

HZ52用途

HZ52是一种有效、可逆的5-脂氧合酶抑制剂,在完整的人类多形核白细胞中以0.7μM的IC50阻断白三烯的合成[1]。

英文名	hz52
英文别名	更多

描述	HZ52是一种有效、可逆的5-脂氧合酶抑制剂,在完整的人类多形核白细胞中以0.7μM的IC50阻断白三烯的合成[1]。
相关类别	研究领域 >> 炎症/免疫信号通路 >> 代谢酶/蛋白酶 >> 5脂氧合酶
参考文献	[1]. Greiner C, et al. 2-(4-(Biphenyl-4-ylamino)-6-chloropyrimidin-2-ylthio)octanoic acid (HZ52)--a novel type of 5-lipoxygenase inhibitor with favourable molecular pharmacology and efficacy in vivo. Br J Pharmacol. 2011 Sep;164(2b):781-93.

密度	1.3±0.1 g/cm3
沸点	625.3±55.0 °C at 760 mmHg
分子式	C₂₄H₂₆ClN₃O₂S
分子量	456.000
闪点	332.0±31.5 °C
精确质量	455.143433
PSA	100.41000
LogP	9.07
蒸汽压	0.0±1.9 mmHg at 25°C
折射率	1.641

危险品运输编码	NONH for all modes of transport

hz49

1167989-90-3

HZ52

1077626-51-7

文献：Koeberle, Andreas; Zettl, Heiko; Greiner, Christine; Wurglics, Mario; Schubert-Zsilavecz, Manfred; Werz, Oliver Journal of Medicinal Chemistry, 2008 , vol. 51, # 24 p. 8068 - 8076

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E2F-1 is the best-described member of the E2F family of transcriptional factors and is particularly interesting in view of its often opposing roles. Our purpose was to examine the immunohistochemical ...

Octanoic acid, 2-[[4-([1,1'-biphenyl]-4-ylamino)-6-chloro-2-pyrimidinyl]thio]-

2-{[4-(4-Biphenylylamino)-6-chloro-2-pyrimidinyl]sulfanyl}octanoic acid