HZ52

Modify Date: 2024-01-03 23:04:29

HZ52 Structure
HZ52 structure
Common Name HZ52
CAS Number 1077626-51-7 Molecular Weight 456.000
Density 1.3±0.1 g/cm3 Boiling Point 625.3±55.0 °C at 760 mmHg
Molecular Formula C24H26ClN3O2S Melting Point N/A
MSDS Chinese USA Flash Point 332.0±31.5 °C

 Use of HZ52


HZ52 is a potent, reversible 5-lipoxygenase inhibitor, blocking leukotriene synthesis with an IC50 of 0.7 μM in intact human polymorphonuclear leukocytes[1].

 Names

Name hz52
Synonym More Synonyms

 HZ52 Biological Activity

Description HZ52 is a potent, reversible 5-lipoxygenase inhibitor, blocking leukotriene synthesis with an IC50 of 0.7 μM in intact human polymorphonuclear leukocytes[1].
Related Catalog
References

[1]. Greiner C, et al. 2-(4-(Biphenyl-4-ylamino)-6-chloropyrimidin-2-ylthio)octanoic acid (HZ52)--a novel type of 5-lipoxygenase inhibitor with favourable molecular pharmacology and efficacy in vivo. Br J Pharmacol. 2011 Sep;164(2b):781-93.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 625.3±55.0 °C at 760 mmHg
Molecular Formula C24H26ClN3O2S
Molecular Weight 456.000
Flash Point 332.0±31.5 °C
Exact Mass 455.143433
PSA 100.41000
LogP 9.07
Vapour Pressure 0.0±1.9 mmHg at 25°C
Index of Refraction 1.641

 Safety Information

RIDADR NONH for all modes of transport

 Synthetic Route

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HZ52 Structure

HZ52

CAS#:1077626-51-7

Literature: Koeberle, Andreas; Zettl, Heiko; Greiner, Christine; Wurglics, Mario; Schubert-Zsilavecz, Manfred; Werz, Oliver Journal of Medicinal Chemistry, 2008 , vol. 51, # 24 p. 8068 - 8076

 Articles1

More Articles
Functional p53 can modulate the relationship between E2F-1 expression and tumor kinetics in Hodgkin lymphoma.

Leuk. Lymphoma 56(3) , 748-54, (2015)

E2F-1 is the best-described member of the E2F family of transcriptional factors and is particularly interesting in view of its often opposing roles. Our purpose was to examine the immunohistochemical ...

 Synonyms

Octanoic acid, 2-[[4-([1,1'-biphenyl]-4-ylamino)-6-chloro-2-pyrimidinyl]thio]-
2-{[4-(4-Biphenylylamino)-6-chloro-2-pyrimidinyl]sulfanyl}octanoic acid
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  • Purity: 98.0%
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