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磺达肝癸钠

更新时间:2024-01-02 17:56:07

磺达肝癸钠结构式
磺达肝癸钠结构式
品牌特惠专场
常用名 磺达肝癸钠 英文名 Fondaparinux Sodium
CAS号 114870-03-0 分子量 1738.16
密度 N/A 沸点 N/A
分子式 C31H53N3Na10O49S8 熔点 N/A
MSDS 美版 闪点 N/A

 磺达肝癸钠用途


Fondaparinux sodium 是一种抗凝血酶依赖性的 factor Xa 抑制剂。

 磺达肝癸钠名称

中文名 磺达肝癸钠
英文名 fondaparinux sodium
中文别名 磺达肝素(癸)钠 | 磺达肝素钠
英文别名 更多

 磺达肝癸钠生物活性

描述 Fondaparinux sodium 是一种抗凝血酶依赖性的 factor Xa 抑制剂。
相关类别
靶点

Factor Xa[1]

体外研究 磺达肝素钠是第一种选择性靶向Xa因子的新型抗凝血剂。对于磺达肝素,其活化单核细胞(ac-M)的IC50值(抗-Xa IU/ml)为0.59±0.05,单核细胞衍生的微粒(MMP)为0.17±0.03 [2]。
体内研究 磺达肝素钠具有线性,剂量依赖性药代动力学特征,其提供高度可预测的响应。磺达肝素钠具有100%生物利用度,起效迅速,半衰期为14至16小时,可在24小时内持续抗血栓形成。该药物不影响凝血酶原时间或活化部分促凝血酶原激酶时间,也不影响血小板功能或聚集[1]。
参考文献

[1]. Bauer KA. et al. Fondaparinux sodium: a selective inhibitor of factor Xa. Am J Health Syst Pharm. 2001 Nov 1;58 Suppl 2:S14-7.

[2]. Ben-Hadj-Khalifa S, et al. Differential coagulation inhibitory effect of fondaparinux, enoxaparin and unfractionated heparin in cell models of thrombin generation. Blood Coagul Fibrinolysis. 2011 Jul;22(5):369-73.

 磺达肝癸钠物理化学性质

分子式 C31H53N3Na10O49S8
分子量 1738.16
PSA 900.82000
储存条件 -20°C,惰性气体存储

 磺达肝癸钠安全信息

危险品运输编码 NONH for all modes of transport

 磺达肝癸钠文献2

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 磺达肝癸钠英文别名

α-D-glucopyranoside, methyl O-2-deoxy-6-O-sulfo-2-(sulfoamino)-α-D-glucopyranosyl-(1->4)-O-β-D-glucopyranuronosyl-(1->4)-O-2-deoxy-3,6-di-O-sulfo-2-(sulfoamino)-α-D-glucopyranosyl-(1->4)-O-2-O-sulfo-α-L-idopyranuronosyl-(1->4)-2-deoxy-2-(sulfoamino)-, 6-(hydrogen sulfate), decasodium salt
Decasodium methyl 2-deoxy-6-O-sulfonato-2-(sulfonatoamino)-α-D-glucopyranosyl-(1->4)-β-D-glucopyranuronosyl-(1->4)-2-deoxy-3,6-di-O-sulfonato-2-(sulfonatoamino)-α-D-glucopyranosyl-(1->4)-2- O-sulfonato-α-L-idopyranuronosyl-(1->;4)-2-deoxy-6-O-sulfonato-2-(sulfonatoamino)-α-D-glucopyranoside
α-D-glucopyranoside, methyl O-2-deoxy-6-O-sulfo-2-(sulfoamino)-α-D-glucopyranosyl-(1->4)-O-β-D-glucopyranuronosyl-(1->4)-O-2-deoxy-3,6-di-O-sulfo-2-(sulfoamino)-α-D-glucopyranosyl-(1->4)-O-2-O-sulfo-α-L-idopyranuronosyl-(1->4)-2-deoxy-2-(sulfoamino)-, 6-(hydrogen sulfate), sodium salt (1:10)
Fondaparin sodium
Arixtra
Fondaparinux sodium
α-D-Glucopyranoside, methyl O-2-deoxy-6-O-sulfo-2-(sulfoamino)-α-D-glucopyranosyl-(1->4)-O-β-D-glucopyranuronosyl-(1->4)-O-2-deoxy-3,6-di-O-sulfo-2-(sulfoamino)-α-D-glucopyranosyl-(1->4 )-O-2-O-sulfo-α-L-idopyranuronosyl-(1->4)-2-deoxy-2-(sulfoamino)-, 6-(hydrogen sulfate), sodium salt (1:10)
Fondaparinux (sodium)
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