[Leu31,Pro34]-Neuropeptide Y(human,rat)

• 常用名: [Leu31,Pro34]-Neuropeptide Y(human,rat)
• 英文名: [Leu31,Pro34]-Neuropeptide Y(human,rat)
• CAS号: 132699-73-1
• 分子量: 4240.67046
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₈₉H₂₈₃N₅₄O₅₆S
• 熔点: N/A
• 闪点: N/A

用途

[Leu31,Pro34]-Neuropeptide Y(human,rat) 是一种特定的神经肽 Y Y1 受体激动剂。[Leu31,Pro34]-Neuropeptide Y(human,rat) 也抑制 Y4, Y5。[Leu31,Pro34]-Neuropeptide Y(human,rat) 可以增加麻醉大鼠的血压,也增加饮食摄入量。

[Leu31,Pro34]-Neuropeptide Y(human,rat)名称

• 中文名: [Leu31,Pro34]-神经肽Y(人类,大鼠)
• 英文名: (4S)-4-[[2-[[(2S)-1-[(2S)-4-amino-2-[[(2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-2-[[(2S)-1-[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxy-propanoyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-3-carboxy-propanoyl]amino]-4-oxo-butanoyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]-5-[[(1S)-2-[[(1S)-2-[(2S)-2-[[(1S)-2-[[(1S)-1-[[(1S)-2-[[(1S)-1-[[(1S)-2-[[(1S)-1-[[(1S)-2-[[(1S)-2-[[(1S)-2-[[(1S)-2-[[(1S)-1-[[(1S)-1-[[(1S)-2-[[(1S)-2-[[(1S,2S)-1-[[(1S)-3-amino-1-[[(1S)-1-[[(1S)-1-[[(1S,2R)-1-[[(1S)-1-[(2S)-2-[[(1S)-1-[[(1S)-2-amino-1-[(4-hydroxyphenyl)methyl]-2-oxo-ethyl]carbamoyl]-4-guanidino-butyl]carbamoyl]pyrrolidine-1-carbonyl]-4-guanidino-butyl]carbamoyl]-2-hydroxy-propyl]carbamoyl]-3-methyl-butyl]carbamoyl]-3-methyl-butyl]carbamoyl]-3-oxo-propyl]carbamoyl]-2-methyl-butyl]amino]-1-[(4-hydroxyphenyl)methyl]-2-oxo-ethyl]amino]-1-(1H-imidazol-4-ylmethyl)-2-oxo-ethyl]carbamoyl]-4-guanidino-butyl]carbamoyl]-3-methyl-butyl]amino]-1-methyl-2-oxo-ethyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]amino]-1-[(4-hydroxyphenyl)methyl]-2-oxo-ethyl]amino]-1-[(4-hydroxyphenyl)methyl]-2-oxo-ethyl]carbamoyl]-4-guanidino-butyl]amino]-1-methyl-2-oxo-ethyl]carbamoyl]-3-methylsulfanyl-propyl]amino]-1-(carboxymethyl)-2-oxo-ethyl]carbamoyl]-3-carboxy-propyl]amino]-1-methyl-2-oxo-ethyl]carbamoyl]pyrrolidin-1-yl]-1-methyl-2-oxo-ethyl]amino]-1-(carboxymethyl)-2-oxo-ethyl]amino]-5-oxo-pentanoic acid

[Leu31,Pro34]-Neuropeptide Y(human,rat)生物活性

• 描述: [Leu31,Pro34]-Neuropeptide Y(human,rat) 是一种特定的神经肽 Y Y1 受体激动剂。[Leu31,Pro34]-Neuropeptide Y(human,rat) 也抑制 Y4, Y5。[Leu31,Pro34]-Neuropeptide Y(human,rat) 可以增加麻醉大鼠的血压,也增加饮食摄入量。
• 相关类别:
  研究领域 >> 心血管疾病
  研究领域 >> 神经疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 神经肽Y受体
• 靶点:

  NPY Y1 receptor

  NPY Y5 receptor

  NPY Y4 receptor

• 体外研究: [Leu31,Pro34]-神经肽Y(人,大鼠)对HEK细胞株Y1、Y4、Y5的Ki值分别为0.39nm、0.499nm和0.31nm。[Leu31,Pro34]-神经肽Y(人,大鼠)在HEK细胞系中Y2的Ki>1000[2]。
• 体内研究: [Leu31,Pro34]-神经肽Y(人,大鼠)(30 pmol；微量注射入室旁核)增加大鼠的进食量(350±400 g)[3]。
• 参考文献:

  [1]. J Fuhlendorff, et al. [Leu31, Pro34]neuropeptide Y: a specific Y₁ receptor agonist. Proc Natl Acad Sci U S A. 1990 Jan;87(1):182-6.

  [2]. K McCrea, et al. 2-36[K4,RYYSA(19-23)]PP a novel Y₅-receptor preferring ligand with strong stimulatory effect on food intake. Regul Pept. 2000 Feb 8;87(1-3):47-58.

  [3]. A Kask, et al. Evidence for involvement of neuropeptide Y receptors in the regulation of food intake: studies with Y₁-selective antagonist BIBP3226. Br J Pharmacol. 1998 Aug;124(7):1507-15.

[Leu31,Pro34]-Neuropeptide Y(human,rat)物理化学性质

• 分子式: C₁₈₉H₂₈₃N₅₄O₅₆S
• 分子量: 4240.67046
• 储存条件: −20°C

[Leu31,Pro34]-Neuropeptide Y(human,rat)安全信息

• WGK德国: 3

[Leu31,Pro34]-Neuropeptide Y(human,rat)英文别名

• (Leu31,Pro34)-Neuropeptide Y (human, rat)