乙二醇-双(β-氨乙醚)-N,N,N′,N′-四乙酸四钠盐

更新时间：2024-01-16 12:20:03

乙二醇-双(β-氨乙醚)-N,N,N′,N′-四乙酸四钠盐结构式	常用名	乙二醇-双(β-氨乙醚)-N,N,N′,N′-四乙酸四钠盐	英文名	ETHYLENE GLYCOL-BIS(BETA-AMINOETHYL ETHER)-N,N,N',N'-TETRAACETIC ACID TETRASODIUM SALT
	CAS号	13368-13-3	分子量	468.275
	密度	N/A	沸点	N/A
	分子式	C₁₄H₂₀N₂Na₄O₁₀	熔点	N/A
	MSDS	美版	闪点	N/A

用途

EGTA四钠是一种特殊的钙离子螯合剂。EGTA四钠在生理pH(7.4)下的表观钙离解常数(Kd)为60.5nm,对Ca2+比Mg2+具有非常高的特异性(Mg2+KD1-10mM)。EGTA四钠显著抑制炎症巨噬细胞的基质粘附能力[1][2]。

中文名	乙二醇二乙醚二胺四乙酸四钠
英文名	Ethylene glycol-bis(beta-aminoethyl ether)-N,N,N,N-tetraacetic acid tetrasodium salt
中文别名	乙二醇双(2-氨基乙基)四乙酸四钠 \| 3,6-二氧杂-1,8-辛二胺四乙酸四钠
英文别名	更多

描述	EGTA四钠是一种特殊的钙离子螯合剂。EGTA四钠在生理pH(7.4)下的表观钙离解常数(Kd)为60.5nm,对Ca2+比Mg2+具有非常高的特异性(Mg2+KD1-10mM)。EGTA四钠显著抑制炎症巨噬细胞的基质粘附能力[1][2]。
相关类别	信号通路 >> 其他 >> 其他研究领域 >> 炎症/免疫
体外研究	EGTA四钠作为根管冲洗剂,以时间和剂量依赖性方式降低炎症巨噬细胞的基质粘附能力。引起IC50的EGTA四钠浓度为202 mM。螯合剂与羟基磷灰石晶体中的钙离子反应生成金属螯合物。去除牙本质中的钙离子会使牙本质组织更柔软,尤其是富含羟基磷灰石的管周牙本质,并增加暴露的牙本质小管的直径[2]。
参考文献	[1]. Harris RA, Hanrahan JW. Effects of EGTA on calcium signaling in airway epithelial cells. Am J Physiol. 1994;267(5 Pt 1):C1426-C1434. doi:10.1152/ajpcell.1994.267.5.C1426. [2]. Segura-Egea JJ, Jiménez-Rubio A, Rios-Santos JV, Velasco-Ortega E, Calvo-Gutierrez JR. In vitro inhibitory effect of EGTA on macrophage adhesion: endodontic implications. J Endod. 2003;29(3):211-213.

分子式	C₁₄H₂₀N₂Na₄O₁₀
分子量	468.275
精确质量	468.070862
PSA	185.46000
储存条件	室温，密闭，干燥

MSDS英文版

个人防护装备	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
安全声明 (欧洲)	22-24/25
危险品运输编码	NONH for all modes of transport

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