短杆菌肽

更新时间：2024-01-03 19:21:00

短杆菌肽结构式	常用名	短杆菌肽	英文名	Gramicidin TFA
	CAS号	1405-97-6	分子量	1882.29000
	密度	N/A	沸点	N/A
	分子式	C₉₉H₁₄₀N₂₀O₁₇	熔点	229-230℃
	MSDS	中文版美版	闪点	N/A

短杆菌肽用途

Gramicidin 是一种抗菌肽,组装成膜中的通道并增加其对阳离子的渗透性。

中文名	短杆菌肽
英文名	Gramicidin A
英文别名	更多

描述	Gramicidin 是一种抗菌肽,组装成膜中的通道并增加其对阳离子的渗透性。
相关类别	信号通路 >> 抗感染 >> 细菌研究领域 >> 感染
靶点	Bacterial[1]
体外研究	短杆菌肽是一种抗菌肽,作为膜中的通道组装并增加其对阳离子的渗透性。对于大肠杆菌和酿酒酵母的短杆菌素活性较差,如通过一系列短杆菌肽浓度的微生物存活率(％)所示,与短杆菌肽对金黄色葡萄球菌的作用形成对比。杀微生物活性发生在一系列低浓度的短杆菌肽和DODAB浓度下,对酿酒酵母无毒[1]。
细胞实验	将微生物和分散体混合并相互作用1小时，然后稀释至20,000倍，每次一式三份地接种0.1mL，并孵育（37℃下24小时）用于CFU计数。将作为平均值±标准偏差的细胞存活率（％）对DODAB和/或短杆菌肽浓度作图。作为不存在DODAB或DODAB /短杆菌肽分散体时细胞活力的对照，将标准细菌悬浮液加入到0.264M D-葡萄糖溶液中，稀释并在琼脂平板上铺展[1]。
参考文献	[1]. Ragioto DA, et al. Novel gramicidin formulations in cationic lipid as broad-spectrum microbicidal agents. Int J Nanomedicine. 2014 Jun 30;9:3183-92.

熔点	229-230℃
分子式	C₉₉H₁₄₀N₂₀O₁₇
分子量	1882.29000
精确质量	1881.07000
PSA	548.99000
LogP	11.26260
蒸汽压	0mmHg at 25°C
储存条件	2-8°C
水溶解性	Practically insoluble in water, soluble in methanol, sparingly soluble in alcohol \| Soluble in acetic acid and lower alcohols. Practically insoluble in water.

短杆菌肽MSDS英文版

个人防护装备	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危害码 (欧洲)	Xn
风险声明 (欧洲)	20/21-36/37/38
安全声明 (欧洲)	26-36-24/25-22
危险品运输编码	NONH for all modes of transport
WGK德国	3
RTECS号	MD8225000

Unsaturated lipids protect the integral membrane peptide gramicidin A from singlet oxygen

FEBS Lett. 588(9) , 1590-5, (2014)

• Unsaturated lipids protect gramicidin channels from photosensitized inactivation. • Photosensitizer binding to membrane is independent of lipid unsaturation. • Double bonds in lipids reduce gramicid...

The contribution of raised intraneuronal chloride to epileptic network activity.

J. Neurosci. 35 , 7715-26, (2015)

Altered inhibitory function is an important facet of epileptic pathology. A key concept is that GABAergic activity can become excitatory if intraneuronal chloride rises. However, it has proved difficu...

Inversion of membrane surface charge by trivalent cations probed with a cation-selective channel.

Langmuir 28(45) , 15824-30, (2012)

We demonstrate that the cation-selective channel formed by gramicidin A can be used as a reliable sensor for studying the multivalent ion accumulation at the surfaces of charged lipid membranes and th...

GRAMICIDIN (gramicidin A shown)

N-Formyl-L-valylglycyl-L-alanyl-D-leucyl-L-alanyl-D-valyl-L-valyl-D-valyl-L-tryptophyl-D-leucyl-L-tryptophyl-D-leucyl-L-tryptophyl-D-leucyl-N-(2-hydroxyethyl)-L-tryptophanamide

L-Tryptophanamide, N-formyl-L-valylglycyl-L-alanyl-D-leucyl-L-alanyl-D-valyl-L-valyl-D-valyl-L-tryptophyl-D-leucyl-L-tryptophyl-D-leucyl-L-tryptophyl-D-leucyl-N-(2-hydroxyethyl)-

GRAMICIDINE

GRAMICIDIN