1405-97-6

• 常用中文名：短杆菌肽
• 常用英文名：Gramicidin TFA
• CAS号：1405-97-6
• 分子式：C₉₉H₁₄₀N₂₀O₁₇
• 分子量：1882.29000
• 相关类别： 原料药 人工合成抗感染类药 抗真菌类药
• 发布时间：2018-03-26 08:00:00
• 更新时间：2024-01-03 19:21:00
• Gramicidin 是一种抗菌肽,组装成膜中的通道并增加其对阳离子的渗透性。

名称

• 中文名: 短杆菌肽
• 英文名: Gramicidin A
• 英文别名: GRAMICIDIN (gramicidin A shown); N-Formyl-L-valylglycyl-L-alanyl-D-leucyl-L-alanyl-D-valyl-L-valyl-D-valyl-L-tryptophyl-D-leucyl-L-tryptophyl-D-leucyl-L-tryptophyl-D-leucyl-N-(2-hydroxyethyl)-L-tryptophanamide; L-Tryptophanamide, N-formyl-L-valylglycyl-L-alanyl-D-leucyl-L-alanyl-D-valyl-L-valyl-D-valyl-L-tryptophyl-D-leucyl-L-tryptophyl-D-leucyl-L-tryptophyl-D-leucyl-N-(2-hydroxyethyl)-; GRAMICIDINE; GRAMICIDIN

物化性质

• 熔点: 229-230℃
• 分子式: C₉₉H₁₄₀N₂₀O₁₇
• 分子量: 1882.29000
• 精确质量: 1881.07000
• PSA: 548.99000
• LogP: 11.26260
• 蒸汽压: 0mmHg at 25°C
• 储存条件: 2-8°C
• 水溶解性: Practically insoluble in water, soluble in methanol, sparingly soluble in alcohol | Soluble in acetic acid and lower alcohols. Practically insoluble in water.

生物活性

• 描述: Gramicidin 是一种抗菌肽,组装成膜中的通道并增加其对阳离子的渗透性。
• 相关类别:
  信号通路 >> 抗感染 >> 细菌
  研究领域 >> 感染
• 靶点:

  Bacterial[1]

• 体外研究: 短杆菌肽是一种抗菌肽,作为膜中的通道组装并增加其对阳离子的渗透性。对于大肠杆菌和酿酒酵母的短杆菌素活性较差,如通过一系列短杆菌肽浓度的微生物存活率(％)所示,与短杆菌肽对金黄色葡萄球菌的作用形成对比。杀微生物活性发生在一系列低浓度的短杆菌肽和DODAB浓度下,对酿酒酵母无毒[1]。
• 细胞实验: 将微生物和分散体混合并相互作用1小时，然后稀释至20,000倍，每次一式三份地接种0.1mL，并孵育（37℃下24小时）用于CFU计数。将作为平均值±标准偏差的细胞存活率（％）对DODAB和/或短杆菌肽浓度作图。作为不存在DODAB或DODAB /短杆菌肽分散体时细胞活力的对照，将标准细菌悬浮液加入到0.264M D-葡萄糖溶液中，稀释并在琼脂平板上铺展[1]。
• 参考文献:

  [1]. Ragioto DA, et al. Novel gramicidin formulations in cationic lipid as broad-spectrum microbicidal agents. Int J Nanomedicine. 2014 Jun 30;9:3183-92.

MSDS

Section 1. Chemical Product and Company Identification Gramicidin DCatalog G1171, G1032 Common Name/ Number(s). Trade Name CAS#1393-88-0 Manufacturer RTECSMD8440000 SPECTRUM CHEMICAL MFG. CORP. TSCATSCA 8(b) inventory: No products were found. Commercial Name(s)Not available. CI# Not available. SynonymNot available. IN CASE OF EMERGENCY Not available. Chemical Name Chemical FamilyNot available.CALL (310) 516-8000 Not available. Chemical Formula SPECTRUM CHEMICAL MFG. CORP. Section 2.Composition and Information on Ingredients Exposure Limits TWA (mg/m3)STEL (mg/m3) CEIL (mg/m3) NameCAS #% by Weight 1) Gramicidin D1393-88-0100 Toxicological DataNot applicable. on Ingredients Section 3. Hazards Identification Potential Acute Health Effects Hazardous in case of ingestion. Slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of inhalation. Potential Chronic HealthHazardous in case of ingestion. Slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of inhalation. Effects CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Not available. Gramicidin D Section 4. First Aid Measures Eye ContactNo known effect on eye contact, rinse with water for a few minutes. Skin ContactAfter contact with skin, wash immediately with plenty of water. Gently and thoroughly wash the contaminated skin with running water and non-abrasive soap. Be particularly careful to clean folds, crevices, creases and groin. Cover the irritated skin with an emollient. If irritation persists, seek medical attention. Wash contaminated clothing before reusing. Serious Skin ContactNot available. InhalationAllow the victim to rest in a well ventilated area. Seek immediate medical attention. Serious InhalationNot available. IngestionDo not induce vomiting. Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not breathing, perform mouth-to-mouth resuscitation. Seek immediate medical attention. Serious IngestionNot available. Section 5. Fire and Explosion Data Flammability of the Product May be combustible at high temperature. Auto-Ignition Temperature Not available. Flash PointsNot available. Flammable LimitsNot available. Not available. Products of Combustion Fire Hazards in Presence of Not available. Various Substances Explosion Hazards in Presence Risks of explosion of the product in presence of mechanical impact: Not available. of Various SubstancesRisks of explosion of the product in presence of static discharge: Not available. Fire Fighting MediaSMALL FIRE: Use DRY chemical powder. and InstructionsLARGE FIRE: Use water spray, fog or foam. Do not use water jet. Special Remarks onNot available. Fire Hazards Special Remarks on Explosion Not available. Hazards Section 6. Accidental Release Measures Small SpillUse appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements. Large Spill Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate through the sanitary system. Gramicidin D Section 7. Handling and Storage PrecautionsKeep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate the residue under a fume hood. Ground all equipment containing material. Do not breathe dust. StorageKeep container dry. Keep in a cool place. Ground all equipment containing material. Keep container tightly closed. Keep in a cool, well-ventilated place. Combustible materials should be stored away from extreme heat and away from strong oxidizing agents. Section 8. Exposure Controls/Personal Protection Engineering ControlsUse process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. Personal ProtectionSafety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Personal Protection in Case of Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used a Large Spillto avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. Exposure LimitsNot available. Section 9. Physical and Chemical Properties Physical state and appearance Solid. (Solid crystalline powder.)Odorless. Odor TasteNot available. Molecular WeightNot available. ColorWhite. pH (1% soln/water)Not available. Boiling PointDecomposes. Melting Point229°C (444.2°F) Critical TemperatureNot available. Not available. Specific Gravity Vapor PressureNot applicable. Not available. Vapor Density VolatilityNot available. Not available. Odor Threshold Water/Oil Dist. Coeff.Not available. Ionicity (in Water)Not available. Not available. Dispersion Properties SolubilityNot available. Section 10. Stability and Reactivity Data StabilityThe product is stable. Instability TemperatureNot available. Conditions of InstabilityNot available. Incompatibility with variousNot available. substances CorrosivityNon-corrosive in presence of glass. Gramicidin D Not available. Special Remarks on Reactivity Not available. Special Remarks on Corrosivity PolymerizationNo. Section 11. Toxicological Information Routes of EntryIngestion. Toxicity to AnimalsLD50: Not available. LC50: Not available. Chronic Effects on Humans Not available. Other Toxic Effects on Hazardous in case of ingestion. HumansSlightly hazardous in case of skin contact (irritant), of inhalation. Special Remarks on Not available. Toxicity to Animals Special Remarks onNot available. Chronic Effects on Humans Special Remarks on otherNot available. Toxic Effects on Humans Section 12. Ecological Information EcotoxicityNot available. Not available. BOD5 and COD Possibly hazardous short term degradation products are not likely. However, long term degradation products may Products of Biodegradation arise. Toxicity of the ProductsThe products of degradation are more toxic. of Biodegradation Special Remarks on theNot available. Products of Biodegradation Section 13. Disposal Considerations Waste Disposal Section 14. Transport Information DOT ClassificationNot a DOT controlled material (United States). IdentificationNot applicable. Not applicable. Special Provisions for Transport DOT (Pictograms) Gramicidin D Section 15. Other Regulatory Information and Pictograms TSCA 8(b) inventory: No products were found. Federal and State Regulations California Proposition 65 Warnings Other RegulationsNot available.. WHMIS (Canada) Not controlled under WHMIS (Canada). Other Classifications DSCL (EEC)This product is not classified according to the EU regulations. Health Hazard HMIS (U.S.A.)1 National Fire Protection 1 Flammability 1 Association (U.S.A.) Fire Hazard 1 0 Reactivity Health Reactivity 0 Specific hazard Personal Protection E WHMIS (Canada) (Pictograms) DSCL (Europe) (Pictograms) TDG (Canada) (Pictograms) ADR (Europe) (Pictograms) Protective Equipment Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Safety glasses. SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 危害码 (欧洲): Xn
• 风险声明 (欧洲): 20/21-36/37/38
• 安全声明 (欧洲): 26-36-24/25-22
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 3
• RTECS号: MD8225000