法罗培南酯

• 常用名: 法罗培南酯
• 英文名: Faropenem medoxomil
• CAS号: 141702-36-5
• 分子量: 397.40000
• 密度: 1.55 g/cm3
• 沸点: 622.3ºC at 760 mmHg
• 分子式: C₁₇H₁₉NO₈S
• 熔点: N/A
• 闪点: N/A

法罗培南酯用途

Faropenem daloxate是口服的β-内酰胺类抗生素。

法罗培南酯名称

• 中文名: 法罗培南酯
• 英文名: (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl (5R,6S)-6-[(1R)-1-hydroxyethyl]-7-oxo-3-[(2R)-oxolan-2-yl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
• 中文别名: (5R,6S)-6-[1(R)-羟基乙基]-2-[2(R)-四氢呋喃基]-2-培南-3-甲酸 5-甲基-2-氧代-1,3-二氧杂环戊烯-4-基甲酯

法罗培南酯生物活性

• 描述: Faropenem daloxate是口服的β-内酰胺类抗生素。
• 相关类别:
  信号通路 >> 抗感染 >> 细菌
  研究领域 >> 感染
• 参考文献:

  [1]. Faqi AS, Lanphear C, Gill S, Colagiovanni DB.Juvenile toxicity study of faropenem medoxomil in beagle puppies.Reprod Toxicol. 2010 Dec;30(4):619-24. Epub 2010 Aug 11.

  [2]. Hadley JA, Tillotson GS, Tosiello R, Echols RM.Faropenem medoxomil: a treatment option in acute bacterial rhinosinusitis.Expert Rev Anti Infect Ther. 2006 Dec;4(6):923-37.

  [3]. Siegert R, Berg O, Gehanno P, Leiberman A, Martinkenas JL, Nikolaidis P, Arvis P, Alefelder M, Reimnitz P.Comparison of the efficacy and safety of faropenem daloxate and cefuroxime axetil for the treatment of acute bacterial maxillary sinusitis in adults.

  [4]. Upchurch J, Rosemore M, Tosiello R, Kowalsky S, Echols R.Randomized double-blind study comparing 7- and 10-day regimens of faropenem medoxomil with a 10-day cefuroxime axetil regimen for treatment of acute bacterial sinusitis.Otolaryngol Head Neck Surg. 2

  [5]. Gettig, Jacob P.; Crank, Christopher W.; Philbrik, Alexander H. Faropenem medoxomil. Annals of Pharmacotherapy (2008), 42(1), 80-90.

法罗培南酯物理化学性质

• 密度: 1.55 g/cm3
• 沸点: 622.3ºC at 760 mmHg
• 分子式: C₁₇H₁₉NO₈S
• 分子量: 397.40000
• 精确质量: 397.08300
• PSA: 144.72000
• LogP: 0.82500
• 外观性状: 白色粉末
• 蒸汽压: 4.3E-18mmHg at 25°C
• 折射率: 1.642
• 储存条件: 2-8℃

法罗培南酯英文别名

• Faropenem medoxomil (USAN)
• (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl (5R,6S)-6-[(1R)-1-hydroxyethyl]-7-oxo-3-[(2R)-tetrahydro-2-furanyl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
• 4-Thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 6-[(1R)-1-hydroxyethyl]-7-oxo-3-[(2R)-tetrahydro-2-furanyl]-, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester, (5R,6S)-
• Faropenem daloxate
• Orapem
• (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl (5R,6S)-6-[(1R)-1-hydroxyethyl]-7-oxo-3-[(2R)-tetrahydrofuran-2-yl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
• Faropenem medoxomil
• A0026